PMID- 28598104
OWN - NLM
STAT- MEDLINE
DCOM- 20181023
LR  - 20181023
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 47
IP  - 5
DP  - 2016 Sep
TI  - [Association of nt3434A→G Mutation in Mitochondrial DNA ND1 Gene with 
      Diabetes Mellitus].
PG  - 810-812
AB  - OBJECTIVES: To study the association of nt3434 A→G mutation in 
      mitochondrial DNA NADH dehydrogenase 1 subunit (ND1) gene with diabetes mellitus. 
      METHODS: PCR-RFLP was used to detect the nt3434 A→G variant of mtDNA ND1 
      gene in 216 diabetic patients and 203 healthy control individuals. 
      Characteristics of mutation and clinical indicators in nt3434A→G family 
      were analyzed. RESULTS: nt3434A→G mutation was detected in one diabetic 
      patient but not found in NC group. This patient had low insulin secretion, low 
      BMI, and elevated serum lactate acids. No significant difference was found in the 
      mutation frequencies between these two groups. nt3434 A→G mutation was also 
      detected in this patient's sister and daughter, who were normal glucose tolerance 
      and had slightly elevated serum lactate acids levels. CONCLUSIONS: Further 
      investigation would be helpful to answer whether nt3434A→G mutation of 
      mitochondrial DNA ND1 gene is associated with an increased risk of diabetes.
FAU - Wang, Xi
AU  - Wang X
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Ren, Yan
AU  - Ren Y
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Wang, Wen
AU  - Wang W
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Song, Jie
AU  - Song J
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Long, Yang
AU  - Long Y
AD  - Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Tian, Hao-Ming
AU  - Tian HM
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Yu, Hong-Ling
AU  - Yu HL
AD  - Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
FAU - Zhang, Xiang-Xun
AU  - Zhang XX
AD  - Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041,China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (DNA, Mitochondrial)
RN  - EC 1.6.99.3 (NADH Dehydrogenase)
RN  - EC 1.6.99.3 (NADH dehydrogenase subunit 1, human)
SB  - IM
MH  - Case-Control Studies
MH  - DNA, Mitochondrial/*genetics
MH  - Diabetes Mellitus/*genetics
MH  - Female
MH  - Humans
MH  - *Mutation
MH  - NADH Dehydrogenase/*genetics
MH  - Polymorphism, Restriction Fragment Length
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Mitochondrial
OT  - Mutation
OT  - nt3434A>G
EDAT- 2017/06/10 06:00
MHDA- 2018/10/24 06:00
CRDT- 2017/06/10 06:00
PHST- 2017/06/10 06:00 [entrez]
PHST- 2017/06/10 06:00 [pubmed]
PHST- 2018/10/24 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2016 Sep;47(5):810-812.