PMID- 28598839
OWN - NLM
STAT- MEDLINE
DCOM- 20180406
LR  - 20220408
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 59
IP  - 1
DP  - 2017
TI  - Functional Disintegration of the Default Mode Network in Prodromal Alzheimer's 
      Disease.
PG  - 169-187
LID - 10.3233/JAD-161120 [doi]
AB  - Neurodegenerative brain changes can affect the functional connectivity strength 
      between nodes of the default-mode network (DMN), which may underlie changes in 
      cognitive performance. It remains unclear how the functional connectivity 
      strength of DMN nodes differs from healthy to pathological aging and whether 
      these changes are cognitively relevant. We used resting-state functional magnetic 
      resonance imaging to investigate the functional connectivity strength across five 
      DMN nodes in 25 healthy controls (HC), 28 subjective cognitive decline (SCD) 
      participants, and 25 prodromal Alzheimer's disease (AD) patients. After 
      identifying the ventral medial prefrontal cortex (vmPFC), posterior cingulate 
      cortex (PCC), retrosplenial cortex (RSC), inferior parietal lobule, and the 
      hippocampus we investigated the functional strength between DMN nodes using 
      temporal network modeling. Functional coupling of the vmPFC and PCC in prodromal 
      AD patients was disrupted. This vmPFC-PCC coupling correlated positively with 
      memory performance in prodromal AD. Furthermore, the hippocampus de-coupled from 
      posterior DMN nodes in SCD and prodromal AD patients. There was no coupling 
      between the hippocampus and the anterior DMN. Additional mediation analyses 
      indicated that the RSC enables communication between the hippocampus and DMN 
      regions in HC but none of the other two groups. These results suggest an 
      anterior-posterior disconnection and a hippocampal de-coupling from posterior DMN 
      nodes with disease progression. Hippocampal de-coupling already occurring in SCD 
      may provide valuable information for the development of a functional biomarker.
FAU - Dillen, Kim N H
AU  - Dillen KNH
AD  - Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research 
      Centre Julich, Julich, Germany.
FAU - Jacobs, Heidi I L
AU  - Jacobs HIL
AD  - Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and 
      Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre 
      Limburg, Maastricht University, Maastricht, The Netherlands.
FAU - Kukolja, Juraj
AU  - Kukolja J
AD  - Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research 
      Centre Julich, Julich, Germany.
AD  - Department of Neurology, University Hospital Cologne, Cologne, Germany.
FAU - Richter, Nils
AU  - Richter N
AD  - Department of Neurology, University Hospital Cologne, Cologne, Germany.
FAU - von Reutern, Boris
AU  - von Reutern B
AD  - Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research 
      Centre Julich, Julich, Germany.
AD  - Department of Neurology, University Hospital Cologne, Cologne, Germany.
FAU - Onur, Ozgur A
AU  - Onur OA
AD  - Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research 
      Centre Julich, Julich, Germany.
AD  - Department of Neurology, University Hospital Cologne, Cologne, Germany.
FAU - Langen, Karl-Josef
AU  - Langen KJ
AD  - Institute of Neuroscience and Medicine (INM-4), Research Centre Julich, Julich, 
      Germany.
AD  - Department of Nuclear Medicine, University of Aachen, Aachen, Germany.
FAU - Fink, Gereon R
AU  - Fink GR
AD  - Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research 
      Centre Julich, Julich, Germany.
AD  - Department of Neurology, University Hospital Cologne, Cologne, Germany.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Alzheimer Disease/*diagnostic imaging/*physiopathology
MH  - Analysis of Variance
MH  - Cognition Disorders/*diagnostic imaging
MH  - Female
MH  - Fluorodeoxyglucose F18
MH  - Functional Laterality
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - *Models, Neurological
MH  - Neural Pathways/*diagnostic imaging
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Positron-Emission Tomography
MH  - Prodromal Symptoms
MH  - Psychiatric Status Rating Scales
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Dementia
OT  - functional MRI
OT  - hippocampus
OT  - memory
EDAT- 2017/06/10 06:00
MHDA- 2018/04/07 06:00
CRDT- 2017/06/10 06:00
PHST- 2017/06/10 06:00 [pubmed]
PHST- 2018/04/07 06:00 [medline]
PHST- 2017/06/10 06:00 [entrez]
AID - JAD161120 [pii]
AID - 10.3233/JAD-161120 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2017;59(1):169-187. doi: 10.3233/JAD-161120.