PMID- 28598841
OWN - NLM
STAT- MEDLINE
DCOM- 20180409
LR  - 20180409
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 59
IP  - 2
DP  - 2017
TI  - Effects of Exercise on Type 2 Diabetes Mellitus-Related Cognitive Impairment 
      and Dementia.
PG  - 503-513
LID - 10.3233/JAD-161154 [doi]
AB  - Cognitive impairment and dementia are common contributors to institutionalization 
      and loss of quality of life in older people. Both type 2 diabetes mellitus (T2DM) 
      and physical inactivity are prevalent and important modifiable risk factors for 
      developing dementia. Physical activity is recommended in the management of T2DM, 
      and there is growing evidence that exercise, a subgroup of physical activity, is 
      also beneficial for maintaining and improving brain structure and function. This 
      paper reviews the evidence for a benefit of exercise on T2DM related cognitive 
      impairment and dementia. In addition, the type (e.g., aerobic, resistance), 
      intensity, duration, and frequency of exercise are discussed. This review shows 
      that although exercise has known benefits on the mechanisms linking T2DM to 
      dementia, there are very few randomized controlled trials examining whether this 
      is the case. It is concluded that the uptake of exercise for the brain has great 
      potential to improve quality of life and provide significant cost savings, but 
      further research is warranted to clarify the effects of exercise on T2DM and 
      those on dementia.
FAU - Callisaya, Michele
AU  - Callisaya M
AD  - Menzies Institute for Medical Research, University of Tasmania, Tasmania, 
      Australia.
AD  - Stroke and Ageing Research Group, Department of Medicine, School of Clinical 
      Sciences at Monash Health, Monash University, Clayton, Australia.
FAU - Nosaka, Kazunori
AU  - Nosaka K
AD  - Centre for Exercise and Sports Science Research, School of Medical and Health 
      Sciences, Edith Cowan University, Joondalup, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Animals
MH  - Brain/physiopathology
MH  - Cognitive Dysfunction/*etiology/*rehabilitation
MH  - Dementia/*etiology/*rehabilitation
MH  - Diabetes Mellitus, Type 2/*complications/rehabilitation
MH  - Exercise Therapy/*methods
MH  - Humans
OTO - NOTNLM
OT  - Aerobic exercise
OT  - brain health
OT  - cognitive function
OT  - eccentric exercise
OT  - physical activity
OT  - resistance exercise
EDAT- 2017/06/10 06:00
MHDA- 2018/04/10 06:00
CRDT- 2017/06/10 06:00
PHST- 2017/06/10 06:00 [pubmed]
PHST- 2018/04/10 06:00 [medline]
PHST- 2017/06/10 06:00 [entrez]
AID - JAD161154 [pii]
AID - 10.3233/JAD-161154 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2017;59(2):503-513. doi: 10.3233/JAD-161154.