PMID- 28599473
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 13
IP  - 6
DP  - 2017 Jun
TI  - Colorectal cancer in cases of multiple primary cancers: Clinical features of 59 
      cases and point mutation analyses.
PG  - 4720-4726
LID - 10.3892/ol.2017.6097 [doi]
AB  - The present study aimed to investigate the occurrence and clinical features of 
      cases of multiple primary cancers including colorectal cancer (MPCC). The medical 
      records of patients with colorectal cancer (CRC) who underwent surgery at the 
      Third Xiangya Hospital of Central South University (Changsha, China) between 
      August 2007 and August 2014 were retrospectively analyzed. Patients with MPCCs 
      were identified and mutation analyses were performed on colon specimens. The 
      results revealed that among 1,311 patients with CRC, 59 had MPCC (including 35 
      cases of >/=1 CRC with >/=1 other cancer type, and 24 cases with multiple CRCs and no 
      other primary cancers). Foci occurred on the right side of the colon (n=32), in 
      the rectum (n=28), and on the left side of the colon (n=24). MPCCs were 
      synchronous in 24 patients, metachronous in 32 patients, and both in 3 patients. 
      Age of onset and presence of polyps were identified as significantly different 
      between MPCC and CRC overall (P<0.05); however, sex or adenoma incidence were not 
      observed to differ significantly between groups. Mutation incidence rates in 26 
      specimens were 11.54% for KRAS proto-oncogene GTPase (KRAS) G13D, 3.85% for KRAS 
      Q61R and 3.85% B-Raf proto-oncogene serine/threonine kinase V600E. Mutations of 
      exon 21 of the epithelial growth factor receptor gene, including L858R and L861Q, 
      and of KRAS G12V were not detected. In conclusion, the likelihood of occurrence 
      of MPCC is closely associated with the age of onset and the presence of polyp(s). 
      Routine examination of multiple systems is necessary for patients with CRC to 
      avoid missed diagnosis and misdiagnosis. Further study is required to demonstrate 
      the molecular mechanism of CRC in cases of multiple primary cancers.
FAU - Wu, Anshan
AU  - Wu A
AD  - Department of Oncology, Third Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
FAU - He, Siqi
AU  - He S
AD  - Department of Oncology, Third Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
AD  - Department of Plastic and Reconstructive Surgery, Third Xiangya Hospital of 
      Central South University, Changsha, Hunan 410013, P.R. China.
FAU - Li, Jingjing
AU  - Li J
AD  - Department of Pathology, Xiangya Basic Medical College, Central South University, 
      Changsha, Hunan 410013, P.R. China.
FAU - Liu, Ling
AU  - Liu L
AD  - Department of Outpatients, Third Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
FAU - Liu, Chunlan
AU  - Liu C
AD  - Department of Gynaecology and Obstetrics, Third Xiangya Hospital of Central South 
      University, Changsha, Hunan 410013, P.R. China.
FAU - Wang, Qi
AU  - Wang Q
AD  - Department of Oncology, Third Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
FAU - Peng, Xiaowei
AU  - Peng X
AD  - Department of Head and Neck Surgery and Oncology Plastic Surgery, The Affiliated 
      Cancer Hospital of Xiangya Medical School, Central South University, Changsha, 
      Hunan 410013, P.R. China.
FAU - Zhou, Jianda
AU  - Zhou J
AD  - Department of Plastic and Reconstructive Surgery, Third Xiangya Hospital of 
      Central South University, Changsha, Hunan 410013, P.R. China.
FAU - Cao, Pei-Guo
AU  - Cao PG
AD  - Department of Oncology, Third Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
FAU - Cao, Ke
AU  - Cao K
AD  - Department of Oncology, Third Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170426
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC5453044
OTO - NOTNLM
OT  - colorectal cancer
OT  - metachronous cancer
OT  - multiple colorectal cancers
OT  - multiple primary colorectal cancers
OT  - synchronous cancer
EDAT- 2017/06/11 06:00
MHDA- 2017/06/11 06:01
PMCR- 2017/04/26
CRDT- 2017/06/11 06:00
PHST- 2016/01/29 00:00 [received]
PHST- 2017/01/06 00:00 [accepted]
PHST- 2017/06/11 06:00 [entrez]
PHST- 2017/06/11 06:00 [pubmed]
PHST- 2017/06/11 06:01 [medline]
PHST- 2017/04/26 00:00 [pmc-release]
AID - OL-0-0-6097 [pii]
AID - 10.3892/ol.2017.6097 [doi]
PST - ppublish
SO  - Oncol Lett. 2017 Jun;13(6):4720-4726. doi: 10.3892/ol.2017.6097. Epub 2017 Apr 
      26.