PMID- 28599667
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20220408
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 16
IP  - 1
DP  - 2017 Jun 9
TI  - Multipolar pacing by cardiac resynchronization therapy with a defibrillators 
      treatment in type 2 diabetes mellitus failing heart patients: impact on 
      responders rate, and clinical outcomes.
PG  - 75
LID - 10.1186/s12933-017-0554-2 [doi]
LID - 75
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a multi factorial disease, 
      affecting clinical outcomes in failing heart patients treated by cardiac 
      resynchronization therapy with a defibrillator (CRT-d). METHODS: One hundred and 
      ninety-five T2DM patients received a CRT-d treatment. Randomly the study 
      population received a CRT-d via multipolar left ventricle (LV) lead pacing (n 99, 
      multipolar group), vs a CRT-d via bipolar LV pacing (n 96, bipolar group). These 
      patients were followed by clinical, and instrumental assessment, and telemetric 
      device control at follow up. In this study we evaluated, in a population of 
      failing heart T2DM patients, cardiac deaths, all cause deaths, arrhythmic events, 
      CRT-d responders rate, hospitalizations for HF worsening, phrenic nerve 
      stimulation (PNS), and LV catheter dislodgment events (and re-intervention for LV 
      catheter re-positioning), comparing multipolar CRT-d vs bipolar CRT-d group of 
      patients at follow up. RESULTS: At follow up there was a statistical significant 
      difference about atrial arrhythmic events [7 (7%) vs 16 (16.7%), p value 0.019], 
      hospitalizations for HF worsening [15 (15.2% vs 24 (25%), p value 0.046], LV 
      catheter dislodgments [1 (1%) vs 9 (9.4%), p value 0018], PNS [5 (5%) vs 18 
      (18.7%), p value 0.007], and LV re-positioning [1 (1%) vs 9 (9.4%), p value 
      0.018], comparing multipolar CRT-d vs bipolar CRT-d group of patients. Multipolar 
      pacing was an independent predictor of all these events. CONCLUSIONS: CRT-d 
      pacing via multipolar LV lead vs bipolar LV lead may reduce arrhythmic burden, 
      hospitalization rate, PNS, LV catheters dislodgments, and re-interventions in 
      T2DM failing heart patients. Clinical trial number NCT03095196.
FAU - Sardu, Celestino
AU  - Sardu C
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples, 
      Italy. drsarducele@gmail.com.
AD  - Cardiovascular and Arrhythmias Department, John Paul II Research and Care 
      Foundation, Campobasso, Italy. drsarducele@gmail.com.
AD  - Cardiovascular Department, Inselspital of Bern University, Bern, Switzerland. 
      drsarducele@gmail.com.
FAU - Barbieri, Michelangela
AU  - Barbieri M
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples, 
      Italy.
FAU - Santamaria, Matteo
AU  - Santamaria M
AD  - Cardiovascular and Arrhythmias Department, John Paul II Research and Care 
      Foundation, Campobasso, Italy.
FAU - Giordano, Valerio
AU  - Giordano V
AD  - Cardiovascular and Arrhythmias Department, John Paul II Research and Care 
      Foundation, Campobasso, Italy.
FAU - Sacra, Cosimo
AU  - Sacra C
AD  - Cardiovascular and Arrhythmias Department, John Paul II Research and Care 
      Foundation, Campobasso, Italy.
FAU - Paolisso, Pasquale
AU  - Paolisso P
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples, 
      Italy.
FAU - Spirito, Alessandro
AU  - Spirito A
AD  - Cardiovascular Department, Inselspital of Bern University, Bern, Switzerland.
FAU - Marfella, Raffaele
AU  - Marfella R
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples, 
      Italy.
FAU - Paolisso, Giuseppe
AU  - Paolisso G
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples, 
      Italy.
FAU - Rizzo, Maria Rosaria
AU  - Rizzo MR
AD  - Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, 
      University of Campania "Luigi Vanvitelli", Piazza Miraglia, 2, 80138, Naples, 
      Italy.
LA  - eng
SI  - ClinicalTrials.gov/NCT03095196
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20170609
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Arrhythmias, Cardiac/etiology
MH  - Cardiac Resynchronization Therapy/adverse effects/*methods/mortality
MH  - Cardiac Resynchronization Therapy Devices
MH  - Defibrillators, Implantable
MH  - Diabetes Mellitus, Type 2/*complications/mortality
MH  - Disease Progression
MH  - Electric Countershock/adverse effects/instrumentation/*methods/mortality
MH  - Female
MH  - Heart Failure/complications/mortality/physiopathology/*therapy
MH  - Humans
MH  - Italy
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Patient Readmission
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Prosthesis Failure
MH  - Recovery of Function
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - *Ventricular Function, Left
MH  - Young Adult
PMC - PMC5466779
EDAT- 2017/06/11 06:00
MHDA- 2018/02/27 06:00
PMCR- 2017/06/09
CRDT- 2017/06/11 06:00
PHST- 2017/05/12 00:00 [received]
PHST- 2017/05/23 00:00 [accepted]
PHST- 2017/06/11 06:00 [entrez]
PHST- 2017/06/11 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2017/06/09 00:00 [pmc-release]
AID - 10.1186/s12933-017-0554-2 [pii]
AID - 554 [pii]
AID - 10.1186/s12933-017-0554-2 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2017 Jun 9;16(1):75. doi: 10.1186/s12933-017-0554-2.