PMID- 28600519
OWN - NLM
STAT- MEDLINE
DCOM- 20190111
LR  - 20220408
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Jun 9
TI  - Alterations in the inflammatory cytokines and brain-derived neurotrophic factor 
      contribute to depression-like phenotype after spared nerve injury: improvement by 
      ketamine.
PG  - 3124
LID - 10.1038/s41598-017-03590-3 [doi]
LID - 3124
AB  - Although pain is frequently accompanied with depression, little is known about 
      the risk factors contributing to individual differences to the comorbidity of 
      pain and depression. In this study, we examined whether cytokines and 
      brain-derived neurotrophic factor (BDNF) might contribute to the individual 
      differences in the development of neuropathic pain-induced depression. Rats were 
      randomly subjected to spared nerved ligation (SNI) or sham surgery. The SNI rats 
      were divided into two groups by the data from depression-related behavioral 
      tests. Rats with depression-like phenotype displayed higher levels of 
      pro-inflammatory cytokines (e.g., interleukin (IL)-1beta, IL-6) as well as imbalance 
      of pro/anti-inflammatory cytokines compared with rats without depression-like 
      phenotype and sham-operated rats. Levels of BDNF in the prefrontal cortex of rats 
      with depression-like phenotype were lower than those of rats without 
      depression-like phenotype and sham-operated rats. A single dose of ketamine 
      ameliorated depression-like behaviors in the rats with depression-like phenotype. 
      Interestingly, higher serum levels of IL-1beta and IL-6 in the rat with 
      depression-like phenotype were normalized after a single dose of ketamine. These 
      findings suggest that alterations in the inflammatory cytokines and BDNF might 
      contribute to neuropathic pain-induced depression, and that serum cytokines may 
      be predictable biomarkers for ketamine's antidepressant actions.
FAU - Xie, Ze-Min
AU  - Xie ZM
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
AD  - Jiangsu Province Key Laboratory of Anesthesiology & Jiangsu Province Laboratory 
      of Anesthetic and Analgesia Application Technology, Xuzhou Medicine University, 
      Xuzhou, China.
FAU - Wang, Xing-Ming
AU  - Wang XM
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
FAU - Xu, Ning
AU  - Xu N
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
AD  - Jiangsu Province Key Laboratory of Anesthesiology & Jiangsu Province Laboratory 
      of Anesthetic and Analgesia Application Technology, Xuzhou Medicine University, 
      Xuzhou, China.
FAU - Wang, Jing
AU  - Wang J
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Pan, Wei
AU  - Pan W
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Tang, Xiao-Hui
AU  - Tang XH
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Zhou, Zhi-Qiang
AU  - Zhou ZQ
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China.
AD  - Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, China.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
AD  - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental 
      Health, Chiba, Japan. hashimoto@faculty.chiba-u.jp.
FAU - Yang, Jian-Jun
AU  - Yang JJ
AUID- ORCID: 0000-0001-6785-9627
AD  - Department of Anesthesiology, Zhongda Hospital, Medical School, Southeast 
      University, Nanjing, China. yjyangjj@126.com.
AD  - Jiangsu Province Key Laboratory of Anesthesiology & Jiangsu Province Laboratory 
      of Anesthetic and Analgesia Application Technology, Xuzhou Medicine University, 
      Xuzhou, China. yjyangjj@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170609
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Analgesics)
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 690G0D6V8H (Ketamine)
SB  - IM
MH  - Analgesics/administration & dosage/pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cytokines/*metabolism
MH  - Depression/drug therapy/etiology/*metabolism
MH  - Disease Models, Animal
MH  - Down-Regulation/drug effects
MH  - Gene Expression Regulation/drug effects
MH  - Ketamine/administration & dosage/pharmacology
MH  - Male
MH  - Peripheral Nerve Injuries/drug therapy/metabolism/*psychology
MH  - Prefrontal Cortex/metabolism
MH  - Random Allocation
MH  - Rats
MH  - Sciatic Nerve/*injuries
PMC - PMC5466642
COIS- The authors declare that they have no competing interests.
EDAT- 2017/06/11 06:00
MHDA- 2019/01/12 06:00
PMCR- 2017/06/09
CRDT- 2017/06/11 06:00
PHST- 2017/01/23 00:00 [received]
PHST- 2017/05/02 00:00 [accepted]
PHST- 2017/06/11 06:00 [entrez]
PHST- 2017/06/11 06:00 [pubmed]
PHST- 2019/01/12 06:00 [medline]
PHST- 2017/06/09 00:00 [pmc-release]
AID - 10.1038/s41598-017-03590-3 [pii]
AID - 3590 [pii]
AID - 10.1038/s41598-017-03590-3 [doi]
PST - epublish
SO  - Sci Rep. 2017 Jun 9;7(1):3124. doi: 10.1038/s41598-017-03590-3.