PMID- 28600633
OWN - NLM
STAT- MEDLINE
DCOM- 20180723
LR  - 20181113
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Linking)
VI  - 32
IP  - 5
DP  - 2017 Oct
TI  - IgM-mediated autoimmune responses to oxidative specific epitopes, but not 
      nitrosylated adducts, are significantly decreased in pregnancy: association with 
      bacterial translocation, perinatal and lifetime major depression and the 
      tryptophan catabolite (TRYCAT) pathway.
PG  - 1571-1583
LID - 10.1007/s11011-017-0040-2 [doi]
AB  - Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and 
      nitric oxide (NO)-adducts are significantly associated with major depression and 
      physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts 
      were assayed in pregnant women with (n = 24) and without prenatal depression 
      (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses 
      to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses 
      to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not 
      NO-adducts, were significantly reduced at the end of term. There were no 
      significant associations between IgM responses to OSEs and perinatal depression, 
      whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly 
      associated with a lifetime major depression. IgM responses to OSEs and 
      NO-cysteinyl were significantly associated with IgA/IgM responses to 
      Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and 
      Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially 
      malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely 
      associated with TRYCAT pathway activity, whilst a lifetime depression and 
      Pseudomonas putida were positively associated. The attenuation of natural 
      IgM-mediated responses to OSEs at the end of term may indicate lowered activity 
      of this part of the compensatory (anti-)inflammatory reflex system and may be 
      partly explained by lowered bacterial translocation. Increased IgM responses to 
      NO-cysteinyl is a biomarker of lifetime depression and may be induced by 
      bacterial translocation. Natural IgM-mediated autoimmune responses, increased 
      nitrosylation and higher CRP levels may have negative regulatory effects on the 
      TRYCAT pathway.
FAU - Roomruangwong, Chutima
AU  - Roomruangwong C
AD  - Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Kanchanatawan, Buranee
AU  - Kanchanatawan B
AD  - Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Sirivichayakul, Sunee
AU  - Sirivichayakul S
AD  - Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand.
FAU - Anderson, George
AU  - Anderson G
AD  - CRC Scotland & London, London, UK.
FAU - Carvalho, Andre F
AU  - Carvalho AF
AD  - Department of Clinical Medicine and Translational Psychiatry Research Group, 
      Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil.
FAU - Duleu, Sebastien
AU  - Duleu S
AD  - Research Department, IDRPHT, Talence, France.
FAU - Geffard, Michel
AU  - Geffard M
AD  - Research Department, IDRPHT, Talence, France.
AD  - GEMAC, Lieu-Dit Berganton, Saint Jean d'Illac, France.
FAU - Maes, Michael
AU  - Maes M
AD  - Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, 
      Thailand. dr.michaelmaes@hotmail.com.
AD  - Department of Psychiatry, Faculty of Medicine, State University of Londrina, 
      Londrina, Brazil. dr.michaelmaes@hotmail.com.
AD  - Department of Psychiatry, Medical University Plovdiv, Plovdiv, Bulgaria. 
      dr.michaelmaes@hotmail.com.
AD  - Revitalis, Waalre, The Netherlands. dr.michaelmaes@hotmail.com.
AD  - IMPACT Research Center, Barwon Health, Deakin University, Geelong, VIC, 
      Australia. dr.michaelmaes@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170609
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Epitopes)
RN  - 0 (Immunoglobulin M)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 343-65-7 (Kynurenine)
RN  - 8DUH1N11BX (Tryptophan)
SB  - IM
MH  - Adult
MH  - Autoimmunity/*immunology
MH  - Bacterial Translocation/*immunology
MH  - Biomarkers
MH  - Cytokines/metabolism
MH  - Depression, Postpartum/immunology/psychology
MH  - Depressive Disorder, Major/epidemiology/*immunology/psychology
MH  - Epitopes/*immunology
MH  - Female
MH  - Gram-Negative Bacteria/immunology
MH  - Humans
MH  - Immunoglobulin M/*immunology
MH  - Inflammation/immunology
MH  - Kynurenine/metabolism
MH  - Metabolic Networks and Pathways
MH  - Nitric Oxide/metabolism
MH  - Pregnancy/*immunology
MH  - Tryptophan/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Compensatory (anti-)inflammatory reflex system (CIRS)
OT  - Cytokines
OT  - Depression
OT  - Immune
OT  - Inflammation
OT  - Kynurenine
EDAT- 2017/06/11 06:00
MHDA- 2018/07/24 06:00
CRDT- 2017/06/11 06:00
PHST- 2017/01/07 00:00 [received]
PHST- 2017/05/24 00:00 [accepted]
PHST- 2017/06/11 06:00 [pubmed]
PHST- 2018/07/24 06:00 [medline]
PHST- 2017/06/11 06:00 [entrez]
AID - 10.1007/s11011-017-0040-2 [pii]
AID - 10.1007/s11011-017-0040-2 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2017 Oct;32(5):1571-1583. doi: 10.1007/s11011-017-0040-2. Epub 
      2017 Jun 9.