PMID- 28600679 OWN - NLM STAT- MEDLINE DCOM- 20180625 LR - 20180710 IS - 1863-2661 (Electronic) IS - 1863-2653 (Linking) VI - 222 IP - 9 DP - 2017 Dec TI - Resting-state BOLD oscillation frequency predicts vigilance task performance at both normal and high environmental temperatures. PG - 4065-4077 LID - 10.1007/s00429-017-1449-4 [doi] AB - Hyperthermia may impair vigilance functions and lead to slower reaction times (RTs) in the psychomotor vigilance task (PVT) and possibly disturbing cerebral hemodynamic rhythms. To test these hypotheses, we acquired the resting-state BOLD and cerebral blood flow (CBF) data, as well as PVTRTs from 15 participants in two simulated environmental thermal conditions (50 degrees C/25 degrees C). We adopted a data-driven method, frequency component analysis, to quantify the mean frequency of the BOLD series of each voxel. Across-subject correlation analysis was employed to detect the brain areas whose BOLD oscillation frequency was correlated with the RTs. Significant changes of BOLD frequency and CBF within these areas were compared between hyperthermia and normothermia conditions. Spatial correlations between BOLD frequency and CBF were calculated within different brain areas for each subject under both thermal conditions. Results showed that, under both thermal conditions, the RTs correlated with the BOLD frequency positively in the default mode network (DMN) and negatively in the sensorimotor network (SMN). The increase of BOLD frequency in the thalamus and ventral medial prefrontal cortex was correlated with the increase of RTs in hyperthermia compared with normothermia. Hyperthermia decreased BOLD frequency and CBF in the SMN, while it increased CBF in the thalamus and posterior cingulate. In both thermal conditions, the spatial distribution of CBF negatively correlated with the spatial distribution of BOLD oscillation frequency in most cortical areas, especially in cingulate cortices, precuneus, and primary visual cortex. These results suggest that hyperthermia might deteriorate task performance by interfering with the resting-state CBF, and with BOLD rhythms. The overlapping of the thermoregulatory and vigilance functions in the SMN and DMN might underlie the neural mechanisms of the cognitive-behavioral impairments induced by hyperthermia. FAU - Song, Xiaopeng AU - Song X AUID- ORCID: 0000-0003-0074-6489 AD - Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China. AD - Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. FAU - Qian, Shaowen AU - Qian S AD - Department of Medical Imaging, Jinan Military General Hospital, Shandong, China. FAU - Liu, Kai AU - Liu K AD - Department of Medical Imaging, Jinan Military General Hospital, Shandong, China. FAU - Zhou, Shuqin AU - Zhou S AD - Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China. AD - Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. FAU - Zhu, Huaiqiu AU - Zhu H AD - Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China. FAU - Zou, Qihong AU - Zou Q AD - Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. FAU - Liu, Yijun AU - Liu Y AD - Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China. FAU - Sun, Gang AU - Sun G AD - Department of Medical Imaging, Jinan Military General Hospital, Shandong, China. cjr.sungang@vip.163.com. FAU - Gao, Jia-Hong AU - Gao JH AD - Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, 100871, China. jgao@pku.edu.cn. AD - McGovern Institute for Brain Research, Peking University, Beijing, 100871, China. jgao@pku.edu.cn. AD - Beijing City Key Lab for Medical Physics and Engineering, Institution of Heavy Ion Physics, School of Physics, Peking University, Beijing, 100871, China. jgao@pku.edu.cn. AD - Shenzhen Institute of Neuroscience, Shenzhen, China. jgao@pku.edu.cn. LA - eng GR - 61131003/National Natural Science Foundation of China/ GR - 81430037/National Natural Science Foundation of China/ GR - 31421003/National Natural Science Foundation of China/ GR - 81671765/National Natural Science Foundation of China/ GR - 2015CB856400/China's National Strategic Basic Research Program/ GR - KQTD2015033016104926/Shenzhen Peacock Plan/ GR - 7172121/Beijing Municipal Natural Science Foundation/ GR - Z161100000216152/Beijing municipal Science and Technology Commission/ GR - Z171100000117012/Beijing Municipal Science & Technology Commission/ GR - Z161100002616006/Beijing Municipal Science and Technology Commission/ PT - Journal Article DEP - 20170609 PL - Germany TA - Brain Struct Funct JT - Brain structure & function JID - 101282001 SB - IM MH - Adult MH - Blood Pressure/physiology MH - Body Temperature MH - Brain/*metabolism MH - *Brain Mapping MH - Cerebrovascular Circulation/*physiology MH - Female MH - Fever/diagnostic imaging MH - Humans MH - Image Processing, Computer-Assisted MH - Magnetic Resonance Imaging MH - Male MH - *Temperature MH - Wakefulness/*physiology MH - Young Adult OTO - NOTNLM OT - Cerebral blood flow OT - Frequency component analysis OT - Hyperthermia OT - Psychomotor vigilance task OT - Resting-state fMRI EDAT- 2017/06/11 06:00 MHDA- 2018/06/26 06:00 CRDT- 2017/06/11 06:00 PHST- 2016/05/25 00:00 [received] PHST- 2017/05/17 00:00 [accepted] PHST- 2017/06/11 06:00 [pubmed] PHST- 2018/06/26 06:00 [medline] PHST- 2017/06/11 06:00 [entrez] AID - 10.1007/s00429-017-1449-4 [pii] AID - 10.1007/s00429-017-1449-4 [doi] PST - ppublish SO - Brain Struct Funct. 2017 Dec;222(9):4065-4077. doi: 10.1007/s00429-017-1449-4. Epub 2017 Jun 9.