PMID- 28600802
OWN - NLM
STAT- MEDLINE
DCOM- 20171023
LR  - 20220330
IS  - 1873-3468 (Electronic)
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 591
IP  - 19
DP  - 2017 Oct
TI  - mTORC1 and mTORC2 as regulators of cell metabolism in immunity.
PG  - 3089-3103
LID - 10.1002/1873-3468.12711 [doi]
AB  - The mechanistic target of rapamycin (mTOR) pathway is an evolutionarily conserved 
      signaling pathway that senses intra- and extracellular nutrients, growth factors, 
      and pathogen-associated molecular patterns to regulate the function of innate and 
      adaptive immune cell populations. In this review, we focus on the role of the 
      mTOR complex 1 (mTORC1) and mTORC2 in the regulation of the cellular energy 
      metabolism of these immune cells to regulate and support immune responses. In 
      this regard, mTORC1 and mTORC2 generally promote an anabolic response by 
      stimulating protein synthesis, glycolysis, mitochondrial functions, and lipid 
      synthesis to influence proliferation and survival, effector and memory responses, 
      innate training and tolerance as well as hematopoietic stem cell maintenance and 
      differentiation. Deactivation of mTOR restores cell homeostasis after immune 
      activation and optimizes antigen presentation and memory T-cell generation. These 
      findings show that the mTOR pathway integrates spatiotemporal information of the 
      environmental and cellular energy status by regulating cellular metabolic 
      responses to guide immune cell activation. Elucidation of the metabolic control 
      mechanisms of immune responses will help to generate a systemic understanding of 
      the immune system.
CI  - (c) 2017 Federation of European Biochemical Societies.
FAU - Linke, Monika
AU  - Linke M
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Austria.
FAU - Fritsch, Stephanie Deborah
AU  - Fritsch SD
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Austria.
FAU - Sukhbaatar, Nyamdelger
AU  - Sukhbaatar N
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Austria.
FAU - Hengstschlager, Markus
AU  - Hengstschlager M
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Austria.
FAU - Weichhart, Thomas
AU  - Weichhart T
AUID- ORCID: 0000-0002-4349-0797
AD  - Center of Pathobiochemistry and Genetics, Institute of Medical Genetics, Medical 
      University of Vienna, Austria.
LA  - eng
GR  - P 27701/FWF_/Austrian Science Fund FWF/Austria
GR  - P 30857/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
PT  - Review
DEP - 20170623
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Multiprotein Complexes)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 1)
RN  - EC 2.7.11.1 (Mechanistic Target of Rapamycin Complex 2)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Cells/*metabolism
MH  - Humans
MH  - *Immunity
MH  - Mechanistic Target of Rapamycin Complex 1
MH  - Mechanistic Target of Rapamycin Complex 2
MH  - Mitochondria/metabolism
MH  - Models, Biological
MH  - Multiprotein Complexes/*metabolism
MH  - TOR Serine-Threonine Kinases/*metabolism
PMC - PMC6322652
MID - EMS81066
OTO - NOTNLM
OT  - T-cell
OT  - dendritic cell
OT  - glycolysis
OT  - immune cell metabolism
OT  - lipid metabolism
OT  - mTORC1
OT  - mTORC2
OT  - macrophage
OT  - mitochondria
EDAT- 2017/06/11 06:00
MHDA- 2017/10/24 06:00
PMCR- 2019/01/07
CRDT- 2017/06/11 06:00
PHST- 2017/04/05 00:00 [received]
PHST- 2017/05/24 00:00 [revised]
PHST- 2017/06/02 00:00 [accepted]
PHST- 2017/06/11 06:00 [pubmed]
PHST- 2017/10/24 06:00 [medline]
PHST- 2017/06/11 06:00 [entrez]
PHST- 2019/01/07 00:00 [pmc-release]
AID - 10.1002/1873-3468.12711 [doi]
PST - ppublish
SO  - FEBS Lett. 2017 Oct;591(19):3089-3103. doi: 10.1002/1873-3468.12711. Epub 2017 
      Jun 23.