PMID- 28601003 OWN - NLM STAT- MEDLINE DCOM- 20180108 LR - 20221207 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 130 DP - 2017 Aug TI - Finding the Optimal volume and intensity of Resistance Training Exercise for Type 2 Diabetes: The FORTE Study, a Randomized Trial. PG - 98-107 LID - S0168-8227(16)31756-9 [pii] LID - 10.1016/j.diabres.2017.05.019 [doi] AB - AIM: To compare different volumes and intensities of resistance training (RT) combined with aerobic training (AT) for improvements in glycemic control and cardiovascular health for persons with type 2 diabetes (T2DM). METHODS: Participants with T2DM were stratified by HbA1c and randomized: "usual care" (RT1), which consisted of moderate intensity (50% 1-repetition maximum [1-RM]), low volumeRT (initiated half-way through program); higher intensity (75% 1-RM) and higher volume (initiated at program onset) RT (RT2); or moderate intensity but higher volume RT (RT3). RT sets and repetitions were adjusted to maintain similar work and volume between RT2 and RT3. Walking or cycling (60-80% aerobic capacity)was prescribed 5 times/week, and RT was prescribed 2 times/week. An ANCOVA, adjusted for baseline and gender, assessed changes post-6months in glycemic control (HbA1c- primary outcome), aerobic capacity and anthropometrics. RESULTS: Sixty-two participants (52.3+/-1.2years, 48% female) were randomized (RT1, n=20; RT2, n=20; RT3, n=22). Only post-training fasting glucose, without significant HbA1c change, was different between groups (RT1-RT3=-1.7mmol/L, p=0.046). Pre-post differences were found in pooled HbA1c (7.4+/-0.2%[57+/-2.2mmol/mol] vs. 6.7+/-0.2%[50+/-2.2mmol/mol], p<0.001), aerobic capacity (21.5+/-0.8vs. 25.2+/-0.8ml/kg/min, p<0.001), body mass (84.0+/-2.7vs. 83.0+/-2.7kg, p=0.022[DXA]), body mass index (30.8+/-0.9vs. 30.3+/-0.8kg/m(2), p=0.02) and body fat (32.3+/-1.1vs. 31.3+/-1.2%, p<0.001). The trial was discontinued early; no HbA1c advantage was found with either RT2 or RT3 over RT1. CONCLUSIONS: Combined AT+RT exercise improved glycemic control, cardiovascular risk factors and body composition after 6months for participants with T2DM, but differential effects between the prescribed intensities and volumes of RT were not found to effect HbA1c. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Yang, Pearl AU - Yang P AD - University Health Network - Toronto Rehab, Cardiovascular Prevention and Rehabilitation Program, 347 Rumsey Road, Toronto, Ontario M4G 1R7, Canada. Electronic address: pearl.yang@mail.utoronto.ca. FAU - Swardfager, Walter AU - Swardfager W AD - University Health Network - Toronto Rehab, Cardiovascular Prevention and Rehabilitation Program, 347 Rumsey Road, Toronto, Ontario M4G 1R7, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada; Department of Pharmacology & Toxicology, University of Toronto, Medical Sciences Building, Room 4207, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada. Electronic address: w.swardfager@utoronto.ca. FAU - Fernandes, Daniel AU - Fernandes D AD - Ross School of Business, University of Michigan, 701 Tappan Avenue, Ann Arbor, MI 48109, USA. Electronic address: dafernan@gmail.com. FAU - Laredo, Sheila AU - Laredo S AD - Women's College Hospital, Department of Endocrinology, 76 Grenville, M5S 1B2 Toronto, Ontario, Canada. Electronic address: Sheila.laredo@wchospital.ca. FAU - Tomlinson, George AU - Tomlinson G AD - Dalla Lana School of Public Health, Division of Biostatistics, University of Toronto, 155 College St, Toronto, Ontario M5T 3M7, Canada; University Health Network - Toronto General Hospital, Department of Medicine, 200 Elizabeth Avenue, Toronto, Ontario M5G 2C4, Canada. Electronic address: George.tomlinson@thebru.ca. FAU - Oh, Paul I AU - Oh PI AD - University Health Network - Toronto Rehab, Cardiovascular Prevention and Rehabilitation Program, 347 Rumsey Road, Toronto, Ontario M4G 1R7, Canada; Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada; Faculty of Kinesiology and Physical Education, University of Toronto, 100 DevonshirePlace, Toronto, Ontario M5S 2C9, Canada. Electronic address: paul.oh@uhn.ca. FAU - Thomas, Scott AU - Thomas S AD - Faculty of Kinesiology and Physical Education, University of Toronto, 100 DevonshirePlace, Toronto, Ontario M5S 2C9, Canada. Electronic address: scott.thomas@utoronto.ca. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20170519 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin A) SB - IM MH - Aged MH - Blood Glucose/analysis MH - Body Composition MH - Body Mass Index MH - Cardiovascular Diseases/prevention & control MH - Diabetes Mellitus, Type 2/complications/*therapy MH - *Exercise MH - Fasting MH - Female MH - Glycated Hemoglobin/analysis MH - Humans MH - Male MH - Middle Aged MH - Resistance Training/*methods MH - Risk Factors OTO - NOTNLM OT - Cardiovascular risk OT - Exercise training OT - Glycemic control OT - RCT EDAT- 2017/06/11 06:00 MHDA- 2018/01/09 06:00 CRDT- 2017/06/11 06:00 PHST- 2017/02/28 00:00 [received] PHST- 2017/04/15 00:00 [revised] PHST- 2017/05/16 00:00 [accepted] PHST- 2017/06/11 06:00 [pubmed] PHST- 2018/01/09 06:00 [medline] PHST- 2017/06/11 06:00 [entrez] AID - S0168-8227(16)31756-9 [pii] AID - 10.1016/j.diabres.2017.05.019 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2017 Aug;130:98-107. doi: 10.1016/j.diabres.2017.05.019. Epub 2017 May 19.