PMID- 28601868
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20220410
IS  - 1423-0356 (Electronic)
IS  - 0025-7931 (Linking)
VI  - 94
IP  - 2
DP  - 2017
TI  - Pulmonary Rehabilitation Outcomes after Single or Double Lung Transplantation in 
      Patients with Chronic Obstructive Pulmonary Disease or Interstitial Lung Disease.
PG  - 178-185
LID - 10.1159/000477351 [doi]
AB  - BACKGROUND: Pulmonary rehabilitation (PR) following lung transplantation (LTx) 
      has been shown to be effective with regard to exercise capacity and 
      health-related quality of life (HRQL). However, outcome data is limited with 
      respect to LTx as a population. Differences concerning the effects of PR in 
      patients with single LTx (SLTx) or double LTx (DLTx) have not been studied yet. 
      OBJECTIVES: The aim was to compare possible differences concerning PR outcomes 
      between SLTx and DLTx. METHODS: In a retrospective analysis (period: 1997-2016), 
      data from 722 patients with either chronic obstructive pulmonary disease (COPD; 
      SLTx: n = 129, FEV1 51 +/- 17% pred.; DLTx: n = 204, FEV1 74 +/- 20% pred.) or 
      interstitial lung disease (ILD; SLTx: n = 135, FVC 58 +/- 18% pred.; DLTx: n = 254, 
      FVC 63 +/- 18% pred.) after LTx were included. All patients underwent a specialized 
      inpatient PR program. The data of the 6-minute walk distance (6MWD) and HRQL 
      (physical [PCS] and mental [MCS] component summary of the SF- 36 questionnaire) 
      were analyzed. RESULTS: Independently from the procedure and pretransplant 
      diagnosis, patients significantly (p < 0.05) improved the 6MWD without any 
      differences between SLTx and DLTx (COPD: SLTx: +109 +/- 68 m, DLTx: +117 +/- 82 m; 
      ILD: SLTx: +115 +/- 80 m, DLTx: +132 +/- 77 m). The PCS (COPD: SLTx: +9 +/- 9 points, 
      DLTx: +7 +/- 9 points; ILD: SLTx: +6 +/- 9 points, DLTx: +9 +/- 9 points) and MCS 
      (COPD: SLTx: +8 +/- 15 points, DLTx: +7 +/- 15 points; ILD: SLTx: +10 +/- 13 points, 
      DLTx: +8 +/- 12 points) also improved significantly without any group differences. 
      CONCLUSIONS: LTx patients with a pretransplant diagnosis of COPD or ILD all 
      benefitted significantly and with clinical relevance with regard to exercise 
      capacity and HRQL from an inpatient PR performed within 1 year postoperatively. 
      PR outcomes were similar regardless of SLTx or DLTx.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Schneeberger, Tessa
AU  - Schneeberger T
AD  - Department of Pulmonary Rehabilitation, Philipps University of Marburg, German 
      Center for Lung Research (DZL), Marburg, Germany.
FAU - Gloeckl, Rainer
AU  - Gloeckl R
FAU - Welte, Tobias
AU  - Welte T
FAU - Kenn, Klaus
AU  - Kenn K
LA  - eng
PT  - Journal Article
DEP - 20170610
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - Female
MH  - Forced Expiratory Volume
MH  - Health Status
MH  - Humans
MH  - Lung/*physiopathology
MH  - Lung Diseases, Interstitial/physiopathology/*surgery
MH  - Lung Transplantation/*rehabilitation
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic Obstructive/physiopathology/*surgery
MH  - Quality of Life
MH  - *Respiratory Therapy
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Walk Test
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease
OT  - Exercise training
OT  - Interstitial lung disease
OT  - Lung transplantation
OT  - Pulmonary rehabilitation
EDAT- 2017/06/12 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/06/12 06:00
PHST- 2017/01/20 00:00 [received]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/06/12 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/06/12 06:00 [entrez]
AID - 000477351 [pii]
AID - 10.1159/000477351 [doi]
PST - ppublish
SO  - Respiration. 2017;94(2):178-185. doi: 10.1159/000477351. Epub 2017 Jun 10.