PMID- 28602019
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1439-1902 (Electronic)
IS  - 0171-6425 (Linking)
VI  - 66
IP  - 8
DP  - 2018 Nov
TI  - Cardiac Surgery in Patients with Parkinson's Disease: A Retrospective Analysis of 
      a High-Risk Cohort.
PG  - 629-636
LID - 10.1055/s-0037-1603589 [doi]
AB  - BACKGROUND: Little is known about the perioperative course of patients with 
      Parkinson's disease (PD) undergoing cardiac surgery. The objective of this study 
      was to identify the influence of PD on the perioperative course and to improve 
      treatment. METHODS: Perioperative data were analyzed retrospectively from 130 
      patients undergoing cardiac surgery between September 2001 and April 2013 who had 
      PD and were compared using 1:1 matched-pair analysis with 130 controls not 
      affected by PD. RESULTS: The 30-day all-cause mortality (4.6 vs. 9.2%; p = 0.21; 
      odds ratio [OR] = 0.45; 95% confidence interval [CI]: 0.16, 1.31) and the overall 
      all-cause mortality (27.7 vs. 28.5%; hazard ratio [HR] = 0.96 [0.56, 1.66]; 
      p = 1.00) were not significantly different between PD patients and the control 
      group. Emergency surgery (p = 0.04; OR = 3.20; 95% CI: 1.06, 9.66) and 
      postoperative pneumonia (p < 0.001; OR = 11.3; 95% CI: 3.06, 41.6) were 
      associated with 30-day mortality. Independent predictors of all-cause mortality 
      were age at surgery (p = 0.01; OR = 3.58; 95% CI: 1.38, 9.30), NYHA (New York 
      Heart Association) classification stage IV (p = 0.02; OR = 17.3; 95% CI: 1.52, 
      198), and postoperative pneumonia (p = 0.05; OR = 46.4; 95% CI: 0.97, 2219). We 
      did not observe an association of PD with short- or long-term all-cause mortality 
      after adjustment for associated covariates. CONCLUSIONS: We found that PD is not 
      a significant risk factor for perioperative morbidity and mortality in our 
      cohort. Our study showed that patients with PD had outcomes that were similar to 
      those of non-PD patients.
CI  - Georg Thieme Verlag KG Stuttgart . New York.
FAU - Schroeter, Thomas
AU  - Schroeter T
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
FAU - Vondran, Maximilian
AU  - Vondran M
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
FAU - Wehbe, Mahmoud Sleiman
AU  - Wehbe MS
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
FAU - Mende, Meinhard
AU  - Mende M
AD  - Centre for Clinical Trials, University of Leipzig, Leipzig, Germany.
FAU - Sauer, Matthias
AU  - Sauer M
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
FAU - Aydin, Muhammed Ikbal
AU  - Aydin MI
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
FAU - Bakhtiary, Farhad
AU  - Bakhtiary F
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
FAU - Mohr, Friedrich Wilhelm
AU  - Mohr FW
AD  - Department of Cardiac Surgery, Heart Center Leipzig, Universitatsklinik, Leipzig, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20170611
PL  - Germany
TA  - Thorac Cardiovasc Surg
JT  - The Thoracic and cardiovascular surgeon
JID - 7903387
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Cardiac Surgical Procedures/adverse effects/mortality
MH  - Female
MH  - Heart Diseases/complications/diagnosis/mortality/*surgery
MH  - Humans
MH  - Male
MH  - Parkinson Disease/*complications/diagnosis/mortality
MH  - Postoperative Complications/etiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Time Factors
MH  - Treatment Outcome
COIS- Disclosure The authors report no conflicts of interest in this work.
EDAT- 2017/06/12 06:00
MHDA- 2019/01/29 06:00
CRDT- 2017/06/12 06:00
PHST- 2017/06/12 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2017/06/12 06:00 [entrez]
AID - 10.1055/s-0037-1603589 [doi]
PST - ppublish
SO  - Thorac Cardiovasc Surg. 2018 Nov;66(8):629-636. doi: 10.1055/s-0037-1603589. Epub 
      2017 Jun 11.