PMID- 28602185
OWN - NLM
STAT- MEDLINE
DCOM- 20181029
LR  - 20181029
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 173
DP  - 2017 Oct 1
TI  - The synthesis of Gemini-type sulfobetaine based hybrid monolith and its 
      application in hydrophilic interaction chromatography for small polar molecular.
PG  - 113-122
LID - S0039-9140(17)30598-2 [pii]
LID - 10.1016/j.talanta.2017.05.072 [doi]
AB  - In this work, a novel Gemini-type sulfobetaine-based hybrid monolith was 
      fabricated by co-polymerization of a homemade Gemini-type sufobetaine, 1,3-bis 
      (N-(3-sulfopropyl)-N-(methacrylic acid-2-hydroxy propyl ester)-N-methyl 
      ammonium)-propane (BSMMP) with vinyltrimethoxysilane (VTMS) and 
      tetramethoxysilane (TMOS) in the presence of 2'-azobis (2-methylpropionamidine) 
      dihydrochloride (V50) as initiator. The recipe of pre-copolymerization solution 
      for monolith preparation was optimized carefully, and the resulting monolith was 
      characterized by scan electron microscope (SEM), fourier transform infrared 
      spectroscopy (FT-IR) and thermal gravimetry analysis (TGA). The results indicated 
      that the optimized monolith possess homogeneous bio-continue pore structure, and 
      a relatively high proportion of the sulfobetaine groups was successfully 
      introduced into the monolith. The results from permeability test shows that the 
      proposed monoliths have excellent permeability within both water rich mobile 
      phase and acetonitrile rich mobile phase, due to the rigid inorganic framework of 
      hybrid monolith. Results showed that the relative standard deviations (RSDs) of 
      run-to-run, column-to-column and batch-to-batch were less than 1.9%, 3.7% and 
      6.2%, respectively. The lowest plate height value of the column for thiourea was 
      less than 10microm. Furthermore, separating the polar small molecules including 
      nucleosides, the base species, the phenols and the amides were performed within 
      14min, 22min 18min and 9min on the prepared monolith, respectively, good 
      separation effect on these polar small molecules was found, and remarkable 
      hydrophilic retention behavior was observed when an acetonitrile rich mobile 
      phase was applied, attributing to the existence of strong polar Gemini-type 
      sulfobetaine groups. Finally, the potential application of the resulting monolith 
      in complex sample was successfully demonstrated by separating a BSA digest in 
      gradient elution mode.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Tan, Wangming
AU  - Tan W
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China.
FAU - Chang, Feng
AU  - Chang F
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China.
FAU - Shu, Yan
AU  - Shu Y
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China; Hunan University of Medicine, 
      Huaihua 418000, PR China.
FAU - Chen, Ye
AU  - Chen Y
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China.
FAU - Liu, Jingjing
AU  - Liu J
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China; Hunan University of Medicine, 
      Huaihua 418000, PR China.
FAU - Chen, Yingzhuang
AU  - Chen Y
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China. Electronic address: 
      yingzhuangchen2012@163.com.
FAU - Ma, Ming
AU  - Ma M
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China.
FAU - Chen, Bo
AU  - Chen B
AD  - Key Laboratory of Phytochemical R&D of Hunan Province and Key Laboratory of 
      Chemical Biology & Traditional Chinese Medicine Research, Ministry of Education, 
      Hunan Normal University, Changsha 410081, PR China.
LA  - eng
PT  - Journal Article
DEP - 20170526
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
RN  - 0 (Methacrylates)
RN  - 0 (Quaternary Ammonium Compounds)
RN  - 1CS02G8656 (methacrylic acid)
RN  - 3SCV180C9W (Betaine)
RN  - 8CVU22OCJW (sulfobetaine)
SB  - IM
MH  - Betaine/*analogs & derivatives/chemical synthesis/chemistry
MH  - Chemistry Techniques, Synthetic
MH  - *Hydrophobic and Hydrophilic Interactions
MH  - Methacrylates/chemistry
MH  - Polymerization
MH  - Quaternary Ammonium Compounds/*chemistry
OTO - NOTNLM
OT  - Gemini-type sulfobetaines
OT  - Hybrid monolith
OT  - Hydrophilic chromatography
OT  - One-pot method
OT  - Ring opening quaternization
EDAT- 2017/06/13 06:00
MHDA- 2018/10/30 06:00
CRDT- 2017/06/13 06:00
PHST- 2017/02/06 00:00 [received]
PHST- 2017/05/18 00:00 [revised]
PHST- 2017/05/25 00:00 [accepted]
PHST- 2017/06/13 06:00 [entrez]
PHST- 2017/06/13 06:00 [pubmed]
PHST- 2018/10/30 06:00 [medline]
AID - S0039-9140(17)30598-2 [pii]
AID - 10.1016/j.talanta.2017.05.072 [doi]
PST - ppublish
SO  - Talanta. 2017 Oct 1;173:113-122. doi: 10.1016/j.talanta.2017.05.072. Epub 2017 
      May 26.