PMID- 28603646
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 9
IP  - Suppl 5
DP  - 2017 May
TI  - Ten-year experience with endobronchial ultrasound-guided transbronchial needle 
      aspiration: single center results in mediastinal diagnostic and staging.
PG  - S363-S369
LID - 10.21037/jtd.2017.03.115 [doi]
AB  - BACKGROUND: Endobronchial ultrasonography with transbronchial needle aspiration 
      (EBUS-TBNA) is recognized as an accurate and minimal invasive procedure for 
      diagnosis and staging of lung cancer and lymph nodal malignancies. EBUS is 
      recommended as the first choice procedure for mediastinal staging in lung cancer 
      in international guidelines. METHODS: A retrospective evaluation was performed on 
      single center experience with EBUS-TBNA in our thoracic surgery department in a 
      10-year time frame. Main indication for the procedure was suspected 
      non-lymphomatous malignancy in intrathoracic lymph-nodes on computed tomography 
      (CT) or positron emission tomography (PET) scan. All procedures were performed 
      under conscious sedation in a day-hospital setting. All the aspirated specimens 
      were obtained with a 22-gauge needle and were fixed in 10% formalin and paraffin 
      embedded. Sections of 3 micron in thickness were cut and hematoxylin-eosin 
      stained. RESULTS: From October 2005 to August 2016, 496 patients were submitted 
      to EBUS-TBNA. Number of nodal stations punctured was 592 with a mean of 2.25 
      punctures per patient. Diagnosis of malignancy was obtained in 291 patients 
      (58.6%). In 25 cases a nodal metastasis from an extrathoracic primary tumor was 
      diagnosed. Sensitivity, specificity and diagnostic accuracy were 95%, 100% and 
      96% respectively. Negative predictive value was 90% and positive predictive value 
      (PPV) was 100%. When molecular tests were requested, mutational analysis was 
      successfully performed on cell block derived material in 55 out of 56 cases 
      (98.2%), and fluorescence in situ hybridization (FISH) analysis in 26 out of 27 
      cases (96.2%). CONCLUSIONS: EBUS-TBNA in our setting was an accurate and safe 
      tool to diagnose non-lymphomatous nodal malignancies. Interestingly, in our 
      series EBUS-TBNA has demonstrated to yield sufficient tissue for molecular 
      analysis.
FAU - Rosso, Lorenzo
AU  - Rosso L
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Ferrero, Stefano
AU  - Ferrero S
AD  - Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy.
FAU - Mendogni, Paolo
AU  - Mendogni P
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Bonaparte, Eleonora
AU  - Bonaparte E
AD  - Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 
      Milan, Italy.
FAU - Carrinola, Rosaria
AU  - Carrinola R
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Palleschi, Alessandro
AU  - Palleschi A
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Righi, Ilaria
AU  - Righi I
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Montoli, Matteo
AU  - Montoli M
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Damarco, Francesco
AU  - Damarco F
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
FAU - Tosi, Davide
AU  - Tosi D
AD  - Thoracic Surgery and Lung Transplantation Unit, Fondazione IRCCS Ca' Granda 
      Ospedale Maggiore Policlinico, Milan, Italy.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC5459875
OTO - NOTNLM
OT  - Endobronchial ultrasound
OT  - lung cancer
OT  - molecular analysis
OT  - transbronchial needle aspiration (TBNA)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/06/13 06:00
MHDA- 2017/06/13 06:01
PMCR- 2017/05/01
CRDT- 2017/06/13 06:00
PHST- 2017/06/13 06:00 [entrez]
PHST- 2017/06/13 06:00 [pubmed]
PHST- 2017/06/13 06:01 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - jtd-09-S5-S363 [pii]
AID - 10.21037/jtd.2017.03.115 [doi]
PST - ppublish
SO  - J Thorac Dis. 2017 May;9(Suppl 5):S363-S369. doi: 10.21037/jtd.2017.03.115.