PMID- 28605290
OWN - NLM
STAT- MEDLINE
DCOM- 20170908
LR  - 20220331
IS  - 1527-7755 (Electronic)
IS  - 0732-183X (Linking)
VI  - 35
IP  - 23
DP  - 2017 Aug 10
TI  - Early Response-Based Therapy Stratification Improves Survival in Adult Early 
      Thymic Precursor Acute Lymphoblastic Leukemia: A Group for Research on Adult 
      Acute Lymphoblastic Leukemia Study.
PG  - 2683-2691
LID - 10.1200/JCO.2016.71.8585 [doi]
AB  - Purpose Early thymic precursor (ETP) acute lymphoblastic leukemia (ALL) is an 
      immunophenotypically defined subgroup of T-cell ALL (T-ALL) associated with high 
      rates of intrinsic treatment resistance. Studies in children have shown that the 
      negative prognostic impact of chemotherapy resistance is abrogated by the 
      implementation of early response-based intensification strategies. Comparable 
      data in adults are lacking. Patients and Methods We performed comprehensive 
      clinicobiologic, genetic, and survival analyses of a large cohort of 213 adult 
      patients with T-ALL, including 47 patients with ETP-ALL, treated in the GRAALL 
      (Group for Research on Adult Acute Lymphoblastic Leukemia) -2003 and -2005 
      studies. Results Targeted next-generation sequencing revealed that the genotype 
      of immunophenotypically defined adult T-ALL is similar to the pediatric 
      equivalent, with high rates of mutations in factors involved in cytokine receptor 
      and RAS signaling (62.2%), hematopoietic development (29.7%), and chemical 
      modification of histones (48.6%). In contrast to pediatric cases, mutations in 
      DNA methylation factor genes were also common (32.4%). We found that despite 
      expected high levels of early bone marrow chemotherapy resistance (87%), the 
      overall prognosis for adults with ETP-ALL treated using the GRAALL protocols was 
      not inferior to that of the non-ETP-ALL group (5-year overall survival: ETP, 
      59.6%; 95% CI, 44.2% to 72.0% v non-ETP, 66.5%; 95% CI, 58.7% to 73.2%; P = 0.33) 
      and that allogeneic stem-cell transplantation had a beneficial effect in a large 
      proportion of patients with ETP-ALL. Conclusion Our results suggest that the use 
      of response-based risk stratification and therapy intensification abrogates the 
      poor prognosis of adult ETP-ALL.
FAU - Bond, Jonathan
AU  - Bond J
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Graux, Carlos
AU  - Graux C
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Lhermitte, Ludovic
AU  - Lhermitte L
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Lara, Diane
AU  - Lara D
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Cluzeau, Thomas
AU  - Cluzeau T
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Leguay, Thibaut
AU  - Leguay T
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Cieslak, Agata
AU  - Cieslak A
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Trinquand, Amelie
AU  - Trinquand A
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Pastoret, Cedric
AU  - Pastoret C
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Belhocine, Mohamed
AU  - Belhocine M
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Spicuglia, Salvatore
AU  - Spicuglia S
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Lheritier, Veronique
AU  - Lheritier V
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Lepretre, Stephane
AU  - Lepretre S
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Thomas, Xavier
AU  - Thomas X
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Huguet, Francoise
AU  - Huguet F
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Ifrah, Norbert
AU  - Ifrah N
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Dombret, Herve
AU  - Dombret H
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Macintyre, Elizabeth
AU  - Macintyre E
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Boissel, Nicolas
AU  - Boissel N
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
FAU - Asnafi, Vahid
AU  - Asnafi V
AD  - Jonathan Bond, Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth 
      Macintyre, and Vahid Asnafi, Hopital Necker-Enfants Malades; Jonathan Bond, 
      Ludovic Lhermitte, Agata Cieslak, Amelie Trinquand, Elizabeth Macintyre, and 
      Vahid Asnafi, Institut National de la sante et de la recherche medicale (INSERM) 
      U1151; Herve Dombret and Nicolas Boissel, University Hospital Saint-Louis, Paris; 
      Diane Lara, Hospitalier de Versailles, Le Chesnay; Thomas Cluzeau, Centre 
      Hospitalier Universitaire (CHU) de Nice, Nice; Thibaut Leguay, CHU de Bordeaux, 
      Bordeaux; Cedric Pastoret, CHU de Rennes, Rennes; Mohamed Belhocine and Salvatore 
      Spicuglia, Aix-Marseille University, Marseille; Veronique Lheritier, Centre 
      Hospitalier Lyon Sud; Xavier Thomas, CHU de Lyon, Lyon; Stephane Lepretre, Centre 
      Henri Becquerel and Universite de Rouen Normandie, Rouen; Francoise Huguet, CHU 
      de Toulouse, Toulouse; Norbert Ifrah, CHU d'Angers, Angers, France; and Carlos 
      Graux, Godinne University Hospital, Yvoir, Belgium.
LA  - eng
PT  - Clinical Trial, Phase II
PT  - Clinical Trial, Phase III
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
DEP - 20170612
PL  - United States
TA  - J Clin Oncol
JT  - Journal of clinical oncology : official journal of the American Society of 
      Clinical Oncology
JID - 8309333
RN  - 0 (Histones)
RN  - 0 (Receptors, Cytokine)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - EC 3.6.5.2 (ras Proteins)
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
MH  - Cyclophosphamide/administration & dosage
MH  - DNA Methylation/genetics
MH  - DNA Mutational Analysis
MH  - Drug Resistance, Neoplasm
MH  - Female
MH  - Genotype
MH  - Hematopoiesis/genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histones/chemistry
MH  - Humans
MH  - Immunophenotyping
MH  - Male
MH  - Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics/*therapy
MH  - Prognosis
MH  - Receptors, Cytokine/genetics
MH  - Signal Transduction/genetics
MH  - Survival Rate
MH  - Thymus Neoplasms/*genetics/*therapy
MH  - Transplantation, Homologous
MH  - ras Proteins/genetics/metabolism
EDAT- 2017/06/13 06:00
MHDA- 2017/09/09 06:00
CRDT- 2017/06/13 06:00
PHST- 2017/06/13 06:00 [pubmed]
PHST- 2017/09/09 06:00 [medline]
PHST- 2017/06/13 06:00 [entrez]
AID - 10.1200/JCO.2016.71.8585 [doi]
PST - ppublish
SO  - J Clin Oncol. 2017 Aug 10;35(23):2683-2691. doi: 10.1200/JCO.2016.71.8585. Epub 
      2017 Jun 12.