PMID- 28605609
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20180705
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 42
IP  - 10
DP  - 2017 Oct
TI  - Effects of macro- and micronutrients on exercise-induced hepcidin response in 
      highly trained endurance athletes.
PG  - 1036-1043
LID - 10.1139/apnm-2017-0207 [doi]
AB  - Iron deficiency has ergolytic effects on athletic performance. Exercise-induced 
      inflammation impedes iron absorption in the digestive tract by upregulating the 
      expression of the iron regulatory protein, hepcidin. Limited research indicates 
      the potential of specific macro- and micronutrients on blunting exercise-induced 
      hepcidin. Therefore, we investigated the effects of postexercise supplementation 
      with protein and carbohydrate (CHO) and vitamins D(3) and K(2) on the 
      postexercise hepcidin response. Ten highly trained male cyclists (age: 26.9 +/- 6.4 
      years; maximal oxygen uptake: 67.4 +/- 4.4 mL.kg(-1).min(-1) completed 4 cycling 
      sessions in a randomized, placebo-controlled, single-blinded, triple-crossover 
      study. Experimental days consisted of an 8-min warm-up at 50% power output at 
      maximal oxygen uptake, followed by 8 x 3-min intervals at 85% power output at 
      maximal oxygen uptake with 1.5 min at 60% power output at maximal oxygen uptake 
      between each interval. Blood samples were collected pre- and postexercise, and at 
      3 h postexercise. Three different drinks consisting of CHO (75 g) and protein (25 
      g) with (VPRO) or without (PRO) vitamins D(3) (5000 IU) and K(2) (1000 mug), or a 
      zero-calorie control drink (PLA) were consumed immediately after the postexercise 
      blood sample. Results showed that the postexercise drinks had no significant (p >/= 
      0.05) effect on any biomarker measured. There was a significant (p < 0.05) 
      increase in hepcidin and interleukin-6 following intense cycling intervals in the 
      participants. Hepcidin increased significantly (p < 0.05) from baseline 
      (nmol.L(-1): 9.94 +/- 8.93, 14.18 +/- 14.90, 10.44 +/- 14.62) to 3 h postexercise 
      (nmol.L(-1): 22.27 +/- 13.41, 25.44 +/- 11.91, 22.57 +/- 15.57) in VPRO, PRO, and PLA, 
      respectively. Contrary to our hypothesis, the drink compositions used did not 
      blunt the postexercise hepcidin response in highly trained athletes.
FAU - Dahlquist, Dylan T
AU  - Dahlquist DT
AD  - a UBC Environmental Physiology Laboratory, School of Kinesiology, University of 
      British Columbia, Vancouver, BC V6T 1Z1, Canada.
AD  - b Canadian Sport Institute - Pacific, Victoria, BC V9E 2C5, Canada.
FAU - Stellingwerff, Trent
AU  - Stellingwerff T
AD  - a UBC Environmental Physiology Laboratory, School of Kinesiology, University of 
      British Columbia, Vancouver, BC V6T 1Z1, Canada.
AD  - b Canadian Sport Institute - Pacific, Victoria, BC V9E 2C5, Canada.
FAU - Dieter, Brad P
AU  - Dieter BP
AD  - c Providence Health Care, Providence Sacred Heart Medical Center and Children's 
      Hospital, Spokane, WA 99204, USA.
FAU - McKenzie, Donald C
AU  - McKenzie DC
AD  - a UBC Environmental Physiology Laboratory, School of Kinesiology, University of 
      British Columbia, Vancouver, BC V6T 1Z1, Canada.
AD  - d Division of Sports Medicine, University of British Columbia, Vancouver, BC V6T 
      1Z1, Canada.
FAU - Koehle, Michael S
AU  - Koehle MS
AD  - a UBC Environmental Physiology Laboratory, School of Kinesiology, University of 
      British Columbia, Vancouver, BC V6T 1Z1, Canada.
AD  - d Division of Sports Medicine, University of British Columbia, Vancouver, BC V6T 
      1Z1, Canada.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170612
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Biomarkers)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Hemoglobins)
RN  - 0 (Hepcidins)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (hepcidin 25, human)
RN  - 11032-49-8 (Vitamin K 2)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 9007-73-2 (Ferritins)
RN  - E1UOL152H7 (Iron)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - *Athletes
MH  - Beverages
MH  - Bicycling
MH  - Biomarkers/blood
MH  - British Columbia
MH  - Cholecalciferol/*administration & dosage
MH  - Cross-Over Studies
MH  - *Diet
MH  - Dietary Carbohydrates/*administration & dosage
MH  - Dietary Proteins/*administration & dosage
MH  - Ferritins/blood
MH  - Hemoglobins/metabolism
MH  - Hepcidins/*blood
MH  - Humans
MH  - Interleukin-6/blood
MH  - Iron/blood
MH  - Male
MH  - *Nutritional Status
MH  - Oxygen Consumption
MH  - *Physical Endurance
MH  - Single-Blind Method
MH  - Time Factors
MH  - Vitamin K 2/*administration & dosage
MH  - Young Adult
OTO - NOTNLM
OT  - cycling
OT  - cyclisme
OT  - hydrates de carbone
OT  - inflammation
OT  - iron metabolism
OT  - metabolisme du fer
OT  - protein and carbohydrates
OT  - proteines
OT  - vitamin D
OT  - vitamine D
EDAT- 2017/06/13 06:00
MHDA- 2018/07/06 06:00
CRDT- 2017/06/13 06:00
PHST- 2017/06/13 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PHST- 2017/06/13 06:00 [entrez]
AID - 10.1139/apnm-2017-0207 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2017 Oct;42(10):1036-1043. doi: 10.1139/apnm-2017-0207. 
      Epub 2017 Jun 12.