PMID- 28606593 OWN - NLM STAT- MEDLINE DCOM- 20180126 LR - 20220409 IS - 1878-4046 (Electronic) IS - 1076-6332 (Linking) VI - 24 IP - 8 DP - 2017 Aug TI - Sub-solid Nodule Detection Performance on Reduced-dose Computed Tomography with Iterative Reduction: Comparison Between 20 mA (7 mAs) and 120 mA (42 mAs) Regarding Nodular Size and Characteristics and Association with Size-specific Dose Estimate. PG - 995-1007 LID - S1076-6332(17)30050-8 [pii] LID - 10.1016/j.acra.2017.01.004 [doi] AB - RATIONALE AND OBJECTIVES: This study aimed to compare sub-solid nodule detection performances (SSNDP) on chest computed tomography (CT) with Adaptive Iterative Dose Reduction using Three Dimensional Processing (AIDR 3D) between 7 mAs (0.21 mSv) and 42 mAs (1.28 mSv) in total and in subgroups classified by nodular size, characteristics, and location, and analyze the association of SSNDP with size-specific dose estimate (SSDE). MATERIALS AND METHODS: As part of the Area-detector Computed Tomography for the Investigation of Thoracic Diseases Study, a Japanese multicenter research project, 68 subjects underwent chest CT with 120 kV, 0.35 seconds per rotation, and three tube currents: 240 mA (84 mAs), 120 mA (42 mAs), and 20 mA (7 mAs). The research committee of the study project outlined and approved our study protocols. The institutional review board of each institution approved this study. Axial 2-mm-thick CT images were reconstructed using AIDR 3D. Standard reference was determined by CT images at 84 mAs. Four radiologists recorded SSN presence by continuously distributed rating on CT at 7 mAs and 42 mAs. Receiver operating characteristic analysis was used to evaluate SSNDP at both doses in total and in subgroups classified by nodular longest diameter (LD) (>/=5 mm), characteristics (pure and part-solid), and locations (ventral, intermediate, or dorsal; central or peripheral; and upper, middle, or lower). Detection sensitivity was compared among five groups of SSNs classified based on particular SSDE to nodule on CT with AIDR 3D at 7 mAs. RESULTS: Twenty-two part-solid and 86 pure SSNs were identified. For larger SSNs (LD >/= 5 mm) as well as subgroups classified by nodular locations and part-solid nodules, SSNDP was similar in both methods (area under the receiver operating characteristics curve: 0.96 +/- 0.02 in CT at 7 mAs and 0.97 +/- 0.01 in CT at 42 mAs), with acceptable interobserver agreements in five locations. For larger SSNs (LD >/= 5 mm), on CT at 42 mAs, no significant differences in detection sensitivity were found among the five groups classified by SSDE, whereas on CT with 7 mAs, four groups with SSDE of 0.65 or higher were superior in detection sensitivity to the other group, with SSDE less than 0.65 mGy. CONCLUSIONS: For SSNs with 5 mm or more in cases with normal range of body habitus, CT at 7 mAs was demonstrated to have comparable SSNDP to CT at 42 mAs regardless of nodular location and characteristics, and SSDE higher than 0.65 mGy is desirable to obtain sufficient SSNDP. CI - Copyright (c) 2017 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved. FAU - Nagatani, Yukihiro AU - Nagatani Y AD - Department of Radiology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan. Electronic address: yatsushi@belle.shiga-med.ac.jp. FAU - Takahashi, Masashi AU - Takahashi M AD - Department of Radiology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan. FAU - Ikeda, Mitsuru AU - Ikeda M AD - Department of Radiological and Medical Laboratory Science, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan. FAU - Yamashiro, Tsuneo AU - Yamashiro T AD - Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Okinawa, Japan. FAU - Koyama, Hisanobu AU - Koyama H AD - Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. FAU - Koyama, Mitsuhiro AU - Koyama M AD - Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan. FAU - Moriya, Hiroshi AU - Moriya H AD - Department of Radiology, Ohara General Hospital, Fukushima, Fukushima, Japan. FAU - Noma, Satoshi AU - Noma S AD - Department of Radiology, Tenri Hospital, Tenri, Nara, Japan. FAU - Tomiyama, Noriyuki AU - Tomiyama N AD - Department of Radiology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. FAU - Ohno, Yoshiharu AU - Ohno Y AD - Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. FAU - Murata, Kiyoshi AU - Murata K AD - Department of Radiology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan. FAU - Murayama, Sadayuki AU - Murayama S AD - Department of Radiology, Graduate School of Medical Science, University of the Ryukyus, Nishihara, Okinawa, Japan. CN - investigators of ACTIve study group LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study DEP - 20170609 PL - United States TA - Acad Radiol JT - Academic radiology JID - 9440159 SB - IM MH - Aged MH - Area Under Curve MH - Female MH - Humans MH - Lung Neoplasms/*diagnostic imaging/pathology MH - Male MH - Middle Aged MH - ROC Curve MH - Radiation Dosage MH - *Radiographic Image Interpretation, Computer-Assisted MH - Solitary Pulmonary Nodule/*diagnostic imaging/pathology MH - Tomography, X-Ray Computed/*methods MH - Tumor Burden OTO - NOTNLM OT - Reduced-dose scanning OT - adaptive iterative dose reduction OT - computed tomography OT - diagnostic performance OT - image noise OT - multicenter study OT - size-specific dose estimate OT - sub-solid nodule FIR - Moriya, Hiroshi IR - Moriya H IRAD- Ohara General Hospital, Fukushima, Fukushima, Japan. FIR - Sakuma, Kotaro IR - Sakuma K IRAD- Ohara General Hospital, Fukushima, Fukushima, Japan. FIR - Koyama, Mitsuhiro IR - Koyama M IRAD- Osaka Medical College, Takatsuki, Osaka, Japan. FIR - Honda, Osamu IR - Honda O IRAD- Osaka University, Suita, Osaka, Japan. FIR - Tomiyama, Noriyuki IR - Tomiyama N IRAD- Osaka University, Suita, Osaka, Japan. FIR - Koyama, Hisaonobu IR - Koyama H IRAD- Kobe University, Kobe, Hyogo, Japan. FIR - Ohno, Yoshiharu IR - Ohno Y IRAD- Kobe University, Kobe, Hyogo, Japan. FIR - Sugimura, Kazuro IR - Sugimura K IRAD- Kobe University, Kobe, Hyogo, Japan. FIR - Sakamoto, Ryo IR - Sakamoto R IRAD- Tenri Hospital, Tenri, Nara, Japan. FIR - Nishimoto, Yuko IR - Nishimoto Y IRAD- Tenri Hospital, Tenri, Nara, Japan. FIR - Noma, Satoshi IR - Noma S IRAD- Tenri Hospital, Tenri, Nara, Japan. FIR - Tada, Akihiro IR - Tada A IRAD- Okayama University, Okayama, Okayama, Japan. FIR - Kato, Katsuya IR - Kato K IRAD- Okayama University, Okayama, Okayama, Japan. FIR - Miyara, Tetsuhiro IR - Miyara T IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan. FIR - Yamashiro, Tsuneo IR - Yamashiro T IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan. FIR - Kamiya, Hisashi IR - Kamiya H IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan. FIR - Kamiya, Ayano IR - Kamiya A IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan. FIR - Tanaka, Yuko IR - Tanaka Y IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan. FIR - Murayama, Sadayuki IR - Murayama S IRAD- University of the Ryukyus, Nishihara, Okinawa, Japan. FIR - Nagatani, Yukihiro IR - Nagatani Y IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan. FIR - Nitta, Norihisa IR - Nitta N IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan. FIR - Takahashi, Masashi IR - Takahashi M IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan. FIR - Murata, Kiyoshi IR - Murata K IRAD- Shiga University of Medical Science, Otsu, Shiga, Japan. EDAT- 2017/06/14 06:00 MHDA- 2018/01/27 06:00 CRDT- 2017/06/14 06:00 PHST- 2016/09/03 00:00 [received] PHST- 2017/01/11 00:00 [revised] PHST- 2017/01/13 00:00 [accepted] PHST- 2017/06/14 06:00 [pubmed] PHST- 2018/01/27 06:00 [medline] PHST- 2017/06/14 06:00 [entrez] AID - S1076-6332(17)30050-8 [pii] AID - 10.1016/j.acra.2017.01.004 [doi] PST - ppublish SO - Acad Radiol. 2017 Aug;24(8):995-1007. doi: 10.1016/j.acra.2017.01.004. Epub 2017 Jun 9.