PMID- 28606780 OWN - NLM STAT- MEDLINE DCOM- 20180412 LR - 20180412 IS - 1872-6240 (Electronic) IS - 0006-8993 (Linking) VI - 1669 DP - 2017 Aug 15 TI - Sexual dimorphic expression of TrkB, TrkB-T1, and BDNF in the medial preoptic area of the Syrian hamster. PG - 122-125 LID - S0006-8993(17)30251-2 [pii] LID - 10.1016/j.brainres.2017.06.008 [doi] AB - Neurotrophins regulate many aspects of neuronal function and activity. Specifically, the binding of Brain-derived neurotrophic factor (BDNF) to Tyrosine receptor kinase-B (TrkB) or its truncated version, TrkB-T1, can cause growth and differentiation or dominant inhibition of receptor signaling, respectively. There is evidence that these neurotropic effects on nervous tissue, in both the central and peripheral nervous system, behave differently between the sexes. This study used western blots to examine the expression of these neurotrophins in the medial preoptic area (MPOA), a sexually dimorphic region of the hamster brain that controls male sex behavior. We report that TrkB-FL and BDNF show greater expression in male MPOA tissue, when compared to female. On the contrary, TrkB-T1 is expressed in greater abundance in the female MPOA. Our results indicate a clear sexual dimorphism of neurotrophins in the MPOA of the Syrian hamster. Furthermore, the greater expression of TrkB-FL and BDNF in the male MPOA suggests that these neurotrophins could be promoting synaptic growth to facilitate male-typical copulation. In contrast, the greater TrkB-T1 expression in the female MPOA suggests a possible inhibition of synaptic growth, and may contribute to the lack of male-typical copulation. Altogether, our data suggests that neurotrophins may play a larger role sexual differentiation than previously thought. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Brague, Joe C AU - Brague JC AD - Lehigh University, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: joebrague@gmail.com. FAU - Swann, Jennifer M AU - Swann JM AD - Lehigh University, Iacocca Hall, 111 Research Dr., Bethlehem, PA 18015, United States. Electronic address: jms5@lehigh.edu. LA - eng PT - Journal Article DEP - 20170609 PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Animals MH - Blotting, Western MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Female MH - Male MH - Mesocricetus MH - Preoptic Area/*metabolism MH - Random Allocation MH - Receptor, trkB/*metabolism MH - *Sex Characteristics OTO - NOTNLM OT - BDNF OT - MPOA OT - Neurotrophin OT - Syrian hamster OT - TrkB OT - TrkB-T1 EDAT- 2017/06/14 06:00 MHDA- 2018/04/13 06:00 CRDT- 2017/06/14 06:00 PHST- 2017/02/20 00:00 [received] PHST- 2017/05/16 00:00 [revised] PHST- 2017/06/06 00:00 [accepted] PHST- 2017/06/14 06:00 [pubmed] PHST- 2018/04/13 06:00 [medline] PHST- 2017/06/14 06:00 [entrez] AID - S0006-8993(17)30251-2 [pii] AID - 10.1016/j.brainres.2017.06.008 [doi] PST - ppublish SO - Brain Res. 2017 Aug 15;1669:122-125. doi: 10.1016/j.brainres.2017.06.008. Epub 2017 Jun 9.