PMID- 28607819
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231112
IS  - 2229-5097 (Print)
IS  - 2152-7806 (Electronic)
IS  - 2152-7806 (Linking)
VI  - 8
DP  - 2017
TI  - mTOR activation is increased in pilocytic astrocytomas from older adults compared 
      with children.
PG  - 85
LID - 10.4103/sni.sni_367_16 [doi]
LID - 85
AB  - BACKGROUND: Recent studies suggest that the behavior and biology of WHO grade I 
      pilocytic astrocytomas (PAs) in adults is different than that associated with 
      grade I PAs in children. METHODS: We evaluated Ki-67 labeling, BRAF 
      abnormalities, isocitrate dehydrogenase R132 immunoreactivity phosphorylation 
      (activation) of p44/42 mitogen activated protein kinase (MAPK), and mammalian 
      target of rapamycin (mTOR) in formalin-fixed tissue from 21 adult (18 years or 
      older, mean age 37 years) and 10 children (mean age 9.4 years) WHO grade I PAs. 
      RESULTS: The mean Ki-67 labeling was 4.8% in adults and 3.8% in children. There 
      was no significant difference between Ki-67 labeling in children and adults or 
      either subgroups of adults. No differences were found in phospho p44/42MAPK in 
      adult subgroups (18-33 years and 34 and older) compared to children. 
      Activation/phosphorylation of mTOR was biphasic in adults being significantly 
      lower than children in young adults but significantly higher than children in 
      older adults (age 34 and older). CONCLUSIONS: Identifying mTOR 
      phosphorylation/activation may represent a difference in biology and a new marker 
      to guide chemotherapy with recently approved mTOR inhibitors.
FAU - Johnson, Mahlon D
AU  - Johnson MD
AD  - Department of Pathology, Division of Neuropathology, University of Rochester 
      School of Medicine, Rochester, New York, USA.
FAU - O'Connell, Mary
AU  - O'Connell M
AD  - Department of Pathology, Division of Neuropathology, University of Rochester 
      School of Medicine, Rochester, New York, USA.
FAU - Walter, Kevin
AU  - Walter K
AD  - Department of Neurosurgery, University of Rochester School of Medicine, 
      Rochester, New York, USA.
FAU - Silberstein, Howard
AU  - Silberstein H
AD  - Department of Neurosurgery, University of Rochester School of Medicine, 
      Rochester, New York, USA.
LA  - eng
PT  - Journal Article
DEP - 20170526
PL  - United States
TA  - Surg Neurol Int
JT  - Surgical neurology international
JID - 101535836
PMC - PMC5461564
OTO - NOTNLM
OT  - mTOR
OT  - p44/42MAPK
OT  - pilocytic astrocytoma
COIS- There are no conflicts of interest.
EDAT- 2017/06/14 06:00
MHDA- 2017/06/14 06:01
PMCR- 2017/05/26
CRDT- 2017/06/14 06:00
PHST- 2016/09/14 00:00 [received]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/06/14 06:00 [entrez]
PHST- 2017/06/14 06:00 [pubmed]
PHST- 2017/06/14 06:01 [medline]
PHST- 2017/05/26 00:00 [pmc-release]
AID - SNI-8-85 [pii]
AID - 10.4103/sni.sni_367_16 [doi]
PST - epublish
SO  - Surg Neurol Int. 2017 May 26;8:85. doi: 10.4103/sni.sni_367_16. eCollection 2017.