PMID- 28608236
OWN - NLM
STAT- MEDLINE
DCOM- 20180807
LR  - 20220408
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 42
IP  - 10
DP  - 2017 Oct
TI  - The Neuroprotective Effect of Curcumin Against Nicotine-Induced Neurotoxicity is 
      Mediated by CREB-BDNF Signaling Pathway.
PG  - 2921-2932
LID - 10.1007/s11064-017-2323-8 [doi]
AB  - Nicotine abuse adversely affects brain and causes apoptotic neurodegeneration. 
      Curcumin- a bright yellow chemical compound found in turmeric is associated with 
      neuroprotective properties. The current study was designed to evaluate the role 
      of CREB-BDNF signaling in mediating the neuroprotective effects of curcumin 
      against nicotine-induced apoptosis, oxidative stress and inflammation in rats. 
      Sixty adult male rats were divided randomly into six groups. Group 1 received 
      0.7 ml/rat normal saline, group 2 received 6 mg/kg nicotine. Groups 3, 4, 5 and 6 
      were treated concurrently with nicotine (6 mg/kg) and curcumin (10, 20, 40 and 
      60 mg/kg i.p. respectively) for 21 days. Open Field Test (OFT) was used to 
      evaluate the motor activity. Hippocampal oxidative, anti-oxidant, inflammatory 
      and apoptotic factors were evaluated. Furthermore, phosphorylated brain cyclic 
      adenosine monophosphate (cAMP) response element binding protein (P-CREB) and 
      brain derived neurotrophic factor (BDNF) levels were studied at gene and protein 
      levels. We found that nicotine disturbed the motor activity in OFT and 
      simultaneous treatment with curcumin (40 and 60 mg/kg) reduced the 
      nicotine-induced motor activity disturbances. In addition, nicotine treatment 
      increased lipid peroxidation and the levels of GSH, IL-1beta, TNF-alpha and Bax, while 
      reducing Bcl-2, P-CREB and BDNF levels in the hippocampus. Nicotine also reduced 
      the activity of superoxide dismutase, glutathione peroxidase and glutathione 
      reductase in hippocampus. In contrast, various doses of curcumin attenuated 
      nicotine-induced apoptosis, oxidative stress and inflammation; while elevating 
      P-CREB and BDNF levels. Thus, curcumin via activation of P-CREB/BDNF signaling 
      pathway, confers neuroprotection against nicotine-induced inflammation, apoptosis 
      and oxidative stress.
FAU - Motaghinejad, Majid
AU  - Motaghinejad M
AD  - Razi Drug Research Center and Department of Pharmacology, School of Medicine, 
      Iran University of Medical Sciences, Hemmat High Way, Beside Milad Tower, P. O. 
      Box 14496-14525, Tehran, Iran. Dr.motaghinejad6@gmail.com.
FAU - Motevalian, Manijeh
AU  - Motevalian M
AD  - Razi Drug Research Center and Department of Pharmacology, School of Medicine, 
      Iran University of Medical Sciences, Hemmat High Way, Beside Milad Tower, P. O. 
      Box 14496-14525, Tehran, Iran.
FAU - Fatima, Sulail
AU  - Fatima S
AD  - Razi Drug Research Center and Department of Pharmacology, School of Medicine, 
      Iran University of Medical Sciences, Hemmat High Way, Beside Milad Tower, P. O. 
      Box 14496-14525, Tehran, Iran.
FAU - Faraji, Fahimeh
AU  - Faraji F
AD  - Razi Drug Research Center and Department of Pharmacology, School of Medicine, 
      Iran University of Medical Sciences, Hemmat High Way, Beside Milad Tower, P. O. 
      Box 14496-14525, Tehran, Iran.
FAU - Mozaffari, Shiva
AU  - Mozaffari S
AD  - Polymer Engineering, Islamic Azad University of Tehran, Science and Research 
      Branch, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170612
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Neuroprotective Agents)
RN  - 6M3C89ZY6R (Nicotine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/drug effects
MH  - Hippocampus/metabolism
MH  - Male
MH  - Neuroprotection/*drug effects
MH  - Neuroprotective Agents/*pharmacology
MH  - Neurotoxicity Syndromes/metabolism
MH  - Nicotine/*pharmacology
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Signal Transduction/drug effects
OTO - NOTNLM
OT  - BDNF
OT  - CREB
OT  - Curcumin
OT  - Neurodegeneration
OT  - Nicotine
EDAT- 2017/06/14 06:00
MHDA- 2018/08/08 06:00
CRDT- 2017/06/14 06:00
PHST- 2016/09/30 00:00 [received]
PHST- 2017/06/02 00:00 [accepted]
PHST- 2017/05/16 00:00 [revised]
PHST- 2017/06/14 06:00 [pubmed]
PHST- 2018/08/08 06:00 [medline]
PHST- 2017/06/14 06:00 [entrez]
AID - 10.1007/s11064-017-2323-8 [pii]
AID - 10.1007/s11064-017-2323-8 [doi]
PST - ppublish
SO  - Neurochem Res. 2017 Oct;42(10):2921-2932. doi: 10.1007/s11064-017-2323-8. Epub 
      2017 Jun 12.