PMID- 28608636
OWN - NLM
STAT- MEDLINE
DCOM- 20180208
LR  - 20180208
IS  - 1365-3148 (Electronic)
IS  - 0958-7578 (Linking)
VI  - 27 Suppl 5
DP  - 2017 Oct
TI  - Aetiology and outcome of massive transfusion in two large London teaching 
      hospitals over a 3-year period (2012-2014).
PG  - 342-347
LID - 10.1111/tme.12434 [doi]
AB  - OBJECTIVES: The objectives of this study were to determine: (i) the incidence of 
      massive transfusion (MT) (defined as transfusion of >/=5 red-blood-cell (RBC) units 
      within 4 h, and/or >/=10 RBC units within 24 h of bleeding) over a 3-year period; 
      (ii) the cause, and mortality rate of patients who received MT (from any cause); 
      and (iii) the risk factors for death. BACKGROUND: MT can occur in different 
      clinical settings, yet little is known about its epidemiology/clinical outcomes. 
      METHODS: Data was extracted using transfusion laboratory information management 
      system (LIMS) and patients' electronic databases. RESULTS: We identified 701 
      episodes (incidence 1.7 per 1000 admissions [95% confidence interval (CI): 
      1.6-1.9], belonging to 678 patients (225 females and 453 males, median age 61). 
      Main causes of MT were cardiac surgery (35%), trauma (28%), medical (10%) and 
      vascular surgery (9%). The overall mortality was 32%, and the median number of 
      days spent in hospital was 14 and 2 for those who survived and those who died, 
      respectively. Multivariable analysis showed that cardiac surgery was associated 
      with 56% (95% CI: 9-78%) lower odds of death compared to other surgery, and 
      transfusion of 10-14 RBC and >15 RBC units (compared with 5-9 RBC units) were 
      associated with 2.1 (95% CI: 1.4-3.3) and 9.9 (95% CI: 4.6-21.1) times higher 
      odds of dying, respectively. CONCLUSION: In-hospital morbidity and mortality of 
      MT is high. Future research should focus on unifying the definition of MT, and 
      early identification of the MT markers in order to improve outcomes.
CI  - (c) 2017 British Blood Transfusion Society.
FAU - Green, L
AU  - Green L
AUID- ORCID: 0000-0003-4063-9768
AD  - Department of Haematology, Barts Health NHS Trust, London, UK.
AD  - Barts and the London School of Medicine and Dentistry, Queen Mary University of 
      London, London, UK.
AD  - NHS Blood and Transplant, London, UK.
FAU - Tan, J
AU  - Tan J
AD  - Barts and the London School of Medicine and Dentistry, Queen Mary University of 
      London, London, UK.
FAU - Grist, C
AU  - Grist C
AD  - Department of Haematology, Barts Health NHS Trust, London, UK.
FAU - Kaur, M
AU  - Kaur M
AD  - Department of Haematology, Barts Health NHS Trust, London, UK.
FAU - MacCallum, P
AU  - MacCallum P
AD  - Department of Haematology, Barts Health NHS Trust, London, UK.
AD  - Barts and the London School of Medicine and Dentistry, Queen Mary University of 
      London, London, UK.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20170613
PL  - England
TA  - Transfus Med
JT  - Transfusion medicine (Oxford, England)
JID - 9301182
SB  - IM
MH  - Cardiac Surgical Procedures/*adverse effects
MH  - Erythrocyte Transfusion/*adverse effects
MH  - Female
MH  - *Hospital Mortality
MH  - Hospitals, Teaching
MH  - Humans
MH  - London
MH  - Male
MH  - Risk Factors
MH  - Vascular Surgical Procedures/*adverse effects
MH  - Wounds and Injuries/*mortality/*therapy
OTO - NOTNLM
OT  - causes
OT  - clinical outcomes
OT  - massive transfusion
OT  - transfusion management
EDAT- 2017/06/14 06:00
MHDA- 2018/02/09 06:00
CRDT- 2017/06/14 06:00
PHST- 2017/03/26 00:00 [received]
PHST- 2017/05/14 00:00 [revised]
PHST- 2017/05/24 00:00 [accepted]
PHST- 2017/06/14 06:00 [pubmed]
PHST- 2018/02/09 06:00 [medline]
PHST- 2017/06/14 06:00 [entrez]
AID - 10.1111/tme.12434 [doi]
PST - ppublish
SO  - Transfus Med. 2017 Oct;27 Suppl 5:342-347. doi: 10.1111/tme.12434. Epub 2017 Jun 
      13.