PMID- 28612277
OWN - NLM
STAT- MEDLINE
DCOM- 20180105
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 33
IP  - 12
DP  - 2017 Dec
TI  - 3.0 T magnetic resonance myocardial perfusion imaging for semi-quantitative 
      evaluation of coronary microvascular dysfunction in hypertrophic cardiomyopathy.
PG  - 1949-1959
LID - 10.1007/s10554-017-1189-9 [doi]
AB  - This study aimed to assess coronary microvascular dysfunction (CMD) differences 
      in hypertrophic cardiomyopathy (HCM) patients using cardiac magnetic resonance 
      (CMR) first-pass perfusion and late gadolinium enhancement imaging. Forty-seven 
      patients with HCM and twenty-one healthy volunteers underwent CMR at rest. 
      Imaging protocols included short axis cine, first-pass myocardial perfusion, and 
      late gadolinium enhancement (LGE). Left ventricular end-diastolic wall thickness 
      (EDTH), LGE, time to peak (T(peak)), maximal up-slope (Slope(max)), and peak 
      signal intensity (SI(peak)) were assessed for each myocardial segment. The HCM 
      myocardial segments were grouped by the degree of LGE and hypertrophy. T(peak), 
      SI(peak), Slope(max) and EDTH in multiple groups were assessed and compared by 
      ANOVA test/Kruskal-Wallis test. The Spearman correlation test was used to 
      determine the relationships between EDTH, LGE and perfusion parameters (T(peak), 
      Slope(max) and SI(peak)). Compared to control group segments, T(peak) increased 
      while Slope(max) and SI(peak) decreased in non-LGE/non-hypertrophic segments and 
      LGE/hypertrophic segments in the HCM group, while T(peak) increased more 
      significantly in LGE/hypertrophic segments (all p < 0.05). T(peak) statistically 
      increased with increasing degrees of myocardial LGE (p < 0.01). Differences in 
      T(peak), SI(peak) and EDTH were observed between segments with and without 
      hypertrophy (p < 0.05). EDTH and LGE were positively correlated with T(peak) 
      (r = 0.279, p = 0.031 and r = 0.237, p < 0.001). 3.0 T magnetic resonance 
      myocardial perfusion imaging identifies abnormal perfusion in non-LGE and 
      non-hypertrophic segments of HCM patients, and it may be helpful in the early 
      diagnosis of coronary microvascular dysfunction in HCM. This abnormal perfusion 
      is associated with the severity of myocardial fibrosis and the degree of 
      hypertrophy.
FAU - Yin, Liang
AU  - Yin L
AD  - Department of Radiology, The Second Affiliated Hospital of Nanchang University, 
      No. 1 Minde Road, Nanchang, Jiangxi, China.
AD  - Department of Radiology, Peking University First Hospital, Beijing, China.
FAU - Xu, Hai-Yan
AU  - Xu HY
AD  - Department of Radiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, China.
FAU - Zheng, Sui-Sheng
AU  - Zheng SS
AD  - Department of Radiology, The Second Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, China.
FAU - Zhu, Ying
AU  - Zhu Y
AD  - Department of Radiology, Peking University First Hospital, Beijing, China.
FAU - Xiao, Jiang-Xi
AU  - Xiao JX
AD  - Department of Radiology, Peking University First Hospital, Beijing, China.
FAU - Zhou, Wei
AU  - Zhou W
AD  - Department of Radiology, The Second Affiliated Hospital of Nanchang University, 
      No. 1 Minde Road, Nanchang, Jiangxi, China.
FAU - Yu, Si-Si
AU  - Yu SS
AD  - Department of Radiology, The Second Affiliated Hospital of Nanchang University, 
      No. 1 Minde Road, Nanchang, Jiangxi, China.
FAU - Gong, Liang-Geng
AU  - Gong LG
AD  - Department of Radiology, The Second Affiliated Hospital of Nanchang University, 
      No. 1 Minde Road, Nanchang, Jiangxi, China. gong111999@163.com.
LA  - eng
GR  - 81660284/National Natural Science Foundation of China/
GR  - 20161ACB20013/Major project of Natural Science Foundation of Jiangxi Province/
PT  - Journal Article
DEP - 20170613
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomyopathy, Hypertrophic/*diagnostic imaging/physiopathology
MH  - Case-Control Studies
MH  - Contrast Media/administration & dosage
MH  - *Coronary Circulation
MH  - Coronary Vessels/*diagnostic imaging/physiopathology
MH  - Female
MH  - Fibrosis
MH  - Gadolinium DTPA/administration & dosage
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - *Microcirculation
MH  - Microvessels/*diagnostic imaging/physiopathology
MH  - Middle Aged
MH  - Myocardial Perfusion Imaging/*methods
MH  - Myocardium/pathology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Ventricular Function, Left
MH  - Ventricular Remodeling
OTO - NOTNLM
OT  - Cardiac magnetic resonance
OT  - Coronary microvascular dysfunction
OT  - Hypertrophic cardiomyopathy
OT  - Late gadolinium enhancement
OT  - Myocardial perfusion imaging
EDAT- 2017/06/15 06:00
MHDA- 2018/01/06 06:00
CRDT- 2017/06/15 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/06/09 00:00 [accepted]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2018/01/06 06:00 [medline]
PHST- 2017/06/15 06:00 [entrez]
AID - 10.1007/s10554-017-1189-9 [pii]
AID - 10.1007/s10554-017-1189-9 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2017 Dec;33(12):1949-1959. doi: 
      10.1007/s10554-017-1189-9. Epub 2017 Jun 13.