PMID- 28612486
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20180718
LR  - 20201001
IS  - 1521-4095 (Electronic)
IS  - 0935-9648 (Linking)
VI  - 29
IP  - 31
DP  - 2017 Aug
TI  - High-Density Microfluidic Particle-Cluster-Array Device for Parallel and Dynamic 
      Study of Interaction between Engineered Particles.
LID - 10.1002/adma.201701351 [doi]
AB  - A high-density and high-performance microfluidic particle-cluster-array device 
      utilizing a novel hydrodynamically tunable pneumatic valve (HTPV) is reported for 
      parallel and dynamic monitoring of the interactions taking place in particle 
      clusters. The key concept involves passive operation of the HTPV through elastic 
      deformation of a thin membrane using only the hydrodynamic force inherent in 
      microchannel flows. This unique feature allows the discrete and high-density ( approximately 30 
      HTPVs mm(-2) ) arrangement of numerous HTPVs in a microfluidic channel without 
      any pneumatic connection. In addition, the HTPV achieves high-performance 
      clustering ( approximately 92%) of three different particles in an array format through the 
      optimization of key design and operating parameters. Finally, a 
      contamination-free, parallel, and dynamic biochemical analysis strategy is 
      proposed, which employs a simple one-inlet-one-outlet device operated by the 
      effective combination of several techniques, including particle clustering, the 
      interactions between engineered particles, two-phase partitioning and dehydration 
      control of aqueous plugs, and shape/color-based particle identification.
CI  - (c) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Kim, Hojin
AU  - Kim H
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, South Korea.
FAU - Lee, Sanghyun
AU  - Lee S
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, South Korea.
FAU - Lee, Wonhyung
AU  - Lee W
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, South Korea.
FAU - Kim, Joonwon
AU  - Kim J
AD  - Department of Mechanical Engineering, Pohang University of Science and Technology 
      (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk, 37673, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20170614
PL  - Germany
TA  - Adv Mater
JT  - Advanced materials (Deerfield Beach, Fla.)
JID - 9885358
OTO - NOTNLM
OT  - engineered particles
OT  - microfluidic particle arrays
OT  - particle clustering
OT  - particle interactions
OT  - pneumatic valves
EDAT- 2017/06/15 06:00
MHDA- 2017/06/15 06:01
CRDT- 2017/06/15 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/05/10 00:00 [revised]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2017/06/15 06:01 [medline]
PHST- 2017/06/15 06:00 [entrez]
AID - 10.1002/adma.201701351 [doi]
PST - ppublish
SO  - Adv Mater. 2017 Aug;29(31). doi: 10.1002/adma.201701351. Epub 2017 Jun 14.