PMID- 28612528
OWN - NLM
STAT- MEDLINE
DCOM- 20190528
LR  - 20190528
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 48
IP  - 2
DP  - 2017 Mar
TI  - [Effects of Gubentongluo Formula on Oxidative Stress Reflected by Expressions of 
      PPARalpha and L-FABP in Mice with IgA Nephropathy].
PG  - 210-215
AB  - OBJECTIVES: To determine the underlying mechanism of Gubentongluo Formula in the 
      treatment of IgA nephropathy (IgAN). METHODS: C57BL/6 mice were randomly divided 
      into four groups: normal group (n =10), IgAN group (n =10), control group (n =10) 
      and treatment group (n =10). Mice in the normal and IgAN groups were 
      intragastricly administered with normal saline for 12 weeks; while those in the 
      control and treatment groups were given fenofibrate [30 mg/(kg!$d) and 
      Gubentongluo Formula [1.67 mL/(g!$d)], respectively. Urinary albumin was detected 
      at week 0 and 12. At week 12, protein expressions of peroxisome proliferstor 
      activated receptor alpha (PPARalpha), liver fatty acid-binding proteins (L-FABP), 
      4-hydroxy-2-nonenal (4-HNE), and hemeoxygenase-1(HO-1) in renal tissues were 
      determined by Western blot; mRNA expressions of PPARalpha and L-FABP in renal tissues 
      were determined by florescent quantitative reverse transcription-polymerase chain 
      reaction (qRT-PCR). RESULTS: At week 12, higher levels of urinary albumin, 
      pathological injuries in glomerular mesangial area, and lower expressions of 
      protein and mRNA of PPARalpha and L-FABP were found in mice in the IgAN group 
      compared with those in the normal group (P <0.01). The levels of those indicators 
      decreased in those treated with fenofibrate and Gubentongluo Formule, but still 
      higher than the normal controls (P <0.01). The mice treated with Gubentongluo 
      Formula had more significant improvement than those treated with fenofibrate (P 
      <0.05). CONCLUSION: [CM(155.3mm]Gubentongluo formula can improve proteinuria and 
      pathological injuries in glomerular mesangial area of IgAN mice, due to reduction 
      of oxidative stress in renal tissues through regulating the expressions of PPARalpha 
      and L-FABP.
FAU - Li, Wen-Wen
AU  - Li WW
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
AD  - Shanghai Tranditional Chinese Medicine-integrated Hospital, Shandhai University 
      of Tranditional Chinese Medicine, Shanghai 200082, China.
FAU - Huang, Di
AU  - Huang D
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
FAU - Shen, Pei-Cheng
AU  - Shen PC
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
FAU - Wu, Qing
AU  - Wu Q
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
FAU - Sun, Chuan
AU  - Sun C
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
FAU - Wang, Xian-Xian
AU  - Wang XX
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
FAU - He, Li-Qun
AU  - He LQ
AD  - Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of 
      Traditional Chinese Medicine, Shanghai 200021, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (PPAR alpha)
SB  - IM
MH  - Animals
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Fatty Acid-Binding Proteins/*metabolism
MH  - Glomerulonephritis, IGA/*drug therapy/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Oxidative Stress
MH  - PPAR alpha/*metabolism
MH  - Random Allocation
OTO - NOTNLM
OT  - Gubentongluo Formula
OT  - IgA nephropathy
OT  - L-FABP
OT  - Oxidative stress
OT  - PPARalpha
EDAT- 2017/06/15 06:00
MHDA- 2019/05/29 06:00
CRDT- 2017/06/15 06:00
PHST- 2017/06/15 06:00 [entrez]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2019/05/29 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 Mar;48(2):210-215.