PMID- 28612994
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180821
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 90
IP  - 3
DP  - 2017 Sep
TI  - Strain-based HLA association analysis identified HLA-DRB1*09:01 associated with 
      modern strain tuberculosis.
PG  - 149-156
LID - 10.1111/tan.13070 [doi]
AB  - Tuberculosis (TB) occurs as a result of complex interactions between the host 
      immune system and pathogen virulence factors. Human leukocyte antigen (HLA) class 
      II molecules play an important role in the host immune system. However, no study 
      has assessed the association between HLA class II genes and susceptibility to TB 
      caused by specific strains. This study investigated the possible association of 
      HLA class II genes with TB caused by modern and ancient Mycobacterium 
      tuberculosis (MTB). The study included 682 patients with TB and 836 control 
      subjects who were typed for HLA-DRB1 and HLA-DQB1 alleles. MTB strains were 
      classified using a large sequence polymorphism typing method. Association 
      analysis was performed using common HLA alleles and haplotypes in different MTB 
      strains. HLA association analysis of patients infected with modern MTB strains 
      showed significant association for HLA-DRB1*09:01 (odds ratio [OR] = 1.82; 
      P-value = 9.88 x 10(-4) ) and HLA-DQB1*03:03 alleles (OR = 1.76; P-value = 1.31 x 
      10(-3) ) with susceptibility to TB. Haplotype analysis confirmed that these 
      alleles were in strong linkage disequilibrium and did not exert an interactive 
      effect. Thus, the results of this study showed an association between HLA class 
      II genes and susceptibility to TB caused by modern MTB strains, suggesting the 
      importance of strain-specific analysis to determine susceptibility genes 
      associated with TB.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Toyo-Oka, L
AU  - Toyo-Oka L
AUID- ORCID: 0000-0002-9738-2441
AD  - Medical Genetics Center, Medical Life Science Institute, Department of Medical 
      Sciences, Ministry of Public Health, Nonthaburi, Thailand.
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
FAU - Mahasirimongkol, S
AU  - Mahasirimongkol S
AD  - Medical Genetics Center, Medical Life Science Institute, Department of Medical 
      Sciences, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Yanai, H
AU  - Yanai H
AD  - Fukujuji Hospital, Japan Anti-Tuberculosis Association (JATA), Kiyose, Japan.
AD  - Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA), 
      Kiyose, Japan.
FAU - Mushiroda, T
AU  - Mushiroda T
AD  - Laboratory for Pharmacogenomics, RIKEN Center for Integrative Medical Sciences, 
      Yokohama, Japan.
FAU - Wattanapokayakit, S
AU  - Wattanapokayakit S
AD  - Medical Genetics Center, Medical Life Science Institute, Department of Medical 
      Sciences, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Wichukchinda, N
AU  - Wichukchinda N
AD  - Medical Genetics Center, Medical Life Science Institute, Department of Medical 
      Sciences, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Yamada, N
AU  - Yamada N
AD  - Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (JATA), 
      Kiyose, Japan.
FAU - Smittipat, N
AU  - Smittipat N
AD  - Tuberculosis Research Laboratory, National Center for Genetic Engineering and 
      Biotechnology, National Science and Technology Development Agency, Thailand 
      Science Park (TSP), Pathum Thani, Thailand.
FAU - Juthayothin, T
AU  - Juthayothin T
AD  - Tuberculosis Research Laboratory, National Center for Genetic Engineering and 
      Biotechnology, National Science and Technology Development Agency, Thailand 
      Science Park (TSP), Pathum Thani, Thailand.
FAU - Palittapongarnpim, P
AU  - Palittapongarnpim P
AD  - Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, 
      Thailand.
FAU - Nedsuwan, S
AU  - Nedsuwan S
AD  - Chiangrai Prachanukroh Hospital, Ministry of Public Health, Chiang Rai, Thailand.
FAU - Kantipong, P
AU  - Kantipong P
AD  - Chiangrai Prachanukroh Hospital, Ministry of Public Health, Chiang Rai, Thailand.
FAU - Takahashi, A
AU  - Takahashi A
AD  - Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical 
      Sciences, Yokohama, Japan.
FAU - Kubo, M
AU  - Kubo M
AD  - Laboratory for Genotyping Development, RIKEN Center for Integrative Medical 
      Sciences, Yokohama, Japan.
FAU - Sawanpanyalert, P
AU  - Sawanpanyalert P
AD  - Health Technical Office, Ministry of Public Health, Nonthaburi, Thailand.
FAU - Tokunaga, K
AU  - Tokunaga K
AD  - Department of Human Genetics, Graduate School of Medicine, The University of 
      Tokyo, Tokyo, Japan.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170614
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*09:01 antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-DRB1 Chains/*genetics/immunology
MH  - Humans
MH  - *Linkage Disequilibrium
MH  - Male
MH  - Middle Aged
MH  - *Mycobacterium tuberculosis
MH  - Thailand/epidemiology
MH  - Tuberculosis/epidemiology/*genetics
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - HLA-DQB1
OT  - HLA-DRB1
OT  - human leukocyte antigens
OT  - pathogen-specific association
OT  - tuberculosis
EDAT- 2017/06/15 06:00
MHDA- 2018/04/18 06:00
CRDT- 2017/06/15 06:00
PHST- 2017/01/23 00:00 [received]
PHST- 2017/05/18 00:00 [revised]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/06/15 06:00 [entrez]
AID - 10.1111/tan.13070 [doi]
PST - ppublish
SO  - HLA. 2017 Sep;90(3):149-156. doi: 10.1111/tan.13070. Epub 2017 Jun 14.