PMID- 28613009
OWN - NLM
STAT- MEDLINE
DCOM- 20180507
LR  - 20180507
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 43
IP  - 8
DP  - 2017 Aug
TI  - Independent risk factors for a small placenta and a small-for-gestational-age 
      infant at 35-41 weeks of gestation: An association with circulating 
      angiogenesis-related factor levels at 19-31 weeks of gestation.
PG  - 1285-1292
LID - 10.1111/jog.13360 [doi]
AB  - AIM: Our aim was to investigate the effects of angiogenesis-related factor levels 
      at 19-25 and 26-31 weeks of gestation (WG) on the later occurrence of a 
      small-for-gestational-age (SGA) placenta (small placenta) or an SGA infant 
      delivered at 35-41 WG. METHODS: We measured plasma levels of soluble fms-like 
      tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF), and the serum 
      level of soluble endoglin (sEng) in 679 pregnant women with blood sampling at 
      both 19-25 and 26-31 WG in a prospective study. A small placenta and an SGA 
      infant were defined as <10th percentile, respectively. Multivariate logistic 
      regression analyses were performed using maternal factors, a high mean 
      pulsatility index (high mPI) of the uterine artery in the second trimester, and 
      angiogenesis-related factor levels. RESULTS: Regarding the occurrence of a small 
      placenta, low PlGF at 19-25 WG (adjusted odds ratio [95% confidence interval]: 
      2.4 [1.01-5.7]) and a high mPI (2.5 [1.4-4.3]) were independent risk factors. 
      Moreover, low PlGF at 26-31 WG (3.3 [1.5-7.0]) was also an independent risk 
      factor after adjusting for the effect of mPI. Concerning the occurrence of an SGA 
      infant, a high mPI (2.8 [1.6-5.2]) and high sEng at 26-31 WG (2.3 [1.2-4.5]) were 
      independent risk factors. CONCLUSION: Low levels of PlGF at 19-25 and 26-31 WG 
      were independent risk factors for a small placenta at >/=35 WG; and a high sEng at 
      26-31 WG was an independent risk factor for an SGA infant at >/=35 WG.
CI  - (c) 2017 Japan Society of Obstetrics and Gynecology.
FAU - Hirashima, Chikako
AU  - Hirashima C
AUID- ORCID: 0000-0002-4988-0737
AD  - Department of Obstetrics and Gynecology, Jichi Medical University, 
      Shimotsuke-shi, Japan.
FAU - Ohkuchi, Akihide
AU  - Ohkuchi A
AUID- ORCID: 0000-0002-8861-1572
AD  - Department of Obstetrics and Gynecology, Jichi Medical University, 
      Shimotsuke-shi, Japan.
FAU - Takahashi, Kayo
AU  - Takahashi K
AD  - Department of Obstetrics and Gynecology, Jichi Medical University, 
      Shimotsuke-shi, Japan.
FAU - Suzuki, Hirotada
AU  - Suzuki H
AD  - Department of Obstetrics and Gynecology, Jichi Medical University, 
      Shimotsuke-shi, Japan.
FAU - Shirasuna, Koumei
AU  - Shirasuna K
AUID- ORCID: 0000-0001-6759-6134
AD  - Laboratory of Animal Reproduction, Department of Agriculture, Tokyo University of 
      Agriculture, Atsugi, Japan.
FAU - Matsubara, Shigeki
AU  - Matsubara S
AUID- ORCID: 0000-0003-4378-221X
AD  - Department of Obstetrics and Gynecology, Jichi Medical University, 
      Shimotsuke-shi, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170614
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (ENG protein, human)
RN  - 0 (Endoglin)
RN  - 144589-93-5 (Placenta Growth Factor)
RN  - EC 2.7.10.1 (FLT1 protein, human)
RN  - EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
SB  - IM
MH  - Adult
MH  - Endoglin/*blood
MH  - Female
MH  - Fetal Growth Retardation/*blood
MH  - Gestational Age
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Small for Gestational Age
MH  - Organ Size
MH  - *Placenta
MH  - Placenta Growth Factor/*blood
MH  - Placentation
MH  - Pregnancy
MH  - Vascular Endothelial Growth Factor Receptor-1/*blood
OTO - NOTNLM
OT  - placental growth factor
OT  - small placenta
OT  - small-for-gestational-age infant
OT  - small-for-gestational-age placenta
OT  - soluble endoglin
OT  - soluble fms-like tyrosine kinase 1
EDAT- 2017/06/15 06:00
MHDA- 2018/05/08 06:00
CRDT- 2017/06/15 06:00
PHST- 2016/06/09 00:00 [received]
PHST- 2017/01/26 00:00 [revised]
PHST- 2017/03/27 00:00 [accepted]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2018/05/08 06:00 [medline]
PHST- 2017/06/15 06:00 [entrez]
AID - 10.1111/jog.13360 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2017 Aug;43(8):1285-1292. doi: 10.1111/jog.13360. Epub 
      2017 Jun 14.