PMID- 28613353
OWN - NLM
STAT- MEDLINE
DCOM- 20170913
LR  - 20220408
IS  - 2325-8179 (Electronic)
IS  - 2325-8160 (Linking)
VI  - 48
IP  - 6
DP  - 2017 Jun 1
TI  - Retinal Ganglion Cell Loss in Children With Type 1 Diabetes Mellitus Without 
      Diabetic Retinopathy.
PG  - 473-477
LID - 10.3928/23258160-20170601-05 [doi]
AB  - BACKGROUND AND OBJECTIVE: Early diabetic retinal changes in children with type 1 
      diabetes mellitus (T1DM) without diabetic retinopathy (DR) were examined using 
      spectral-domain optical coherence tomography (SD-OCT). PATIENTS AND METHODS: 
      Sixty children with T1DM without DR and 60 normal children were enrolled in the 
      study. SD-OCT was used to measure the ganglion cell-inner plexiform layer 
      (GC-IPL) and retinal nerve fiber (RNFL) thicknesses in all participants. RESULTS: 
      The GC-IPL thickness was significantly decreased in all quadrants except the 
      superior-nasal quadrant in children with diabetes (P < .05). However, the RNFL 
      thickness in all quadrants was not significantly different between the groups (P 
      > .05). CONCLUSIONS: There was a decreased GC-IPL thickness in children with T1DM 
      without DR, suggesting that T1DM has an early neurodegenerative effect on retinal 
      ganglion cells that occurs when the vascular component of DR is absent. SD-OCT 
      may be more useful than ophthalmoscopic evaluation for detecting the earlier 
      retinal structural changes of diabetes. [Ophthalmic Surg Lasers Imaging Retina. 
      2017;48:473-477.].
CI  - Copyright 2017, SLACK Incorporated.
FAU - Karti, Omer
AU  - Karti O
FAU - Nalbantoglu, Ozlem
AU  - Nalbantoglu O
FAU - Abali, Saygin
AU  - Abali S
FAU - Ayhan, Ziya
AU  - Ayhan Z
FAU - Tunc, Selma
AU  - Tunc S
FAU - Kusbeci, Tuncay
AU  - Kusbeci T
FAU - Ozkan, Behzat
AU  - Ozkan B
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ophthalmic Surg Lasers Imaging Retina
JT  - Ophthalmic surgery, lasers & imaging retina
JID - 101599215
SB  - IM
EIN - Ophthalmic Surg Lasers Imaging Retina. 2017 Jul 1;48(7):530. PMID: 28728179
MH  - Adolescent
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 1/*pathology
MH  - Diabetic Retinopathy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Nerve Fibers/*pathology
MH  - Ophthalmoscopy
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2017/06/15 06:00
MHDA- 2017/09/14 06:00
CRDT- 2017/06/15 06:00
PHST- 2017/06/15 06:00 [entrez]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2017/09/14 06:00 [medline]
AID - 10.3928/23258160-20170601-05 [doi]
PST - ppublish
SO  - Ophthalmic Surg Lasers Imaging Retina. 2017 Jun 1;48(6):473-477. doi: 
      10.3928/23258160-20170601-05.