PMID- 28613373
OWN - NLM
STAT- MEDLINE
DCOM- 20171006
LR  - 20171006
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 16
IP  - 2
DP  - 2017 May 31
TI  - Lack of association between human leukocyte antigen polymorphisms rs9277535 and 
      rs7453920 and chronic hepatitis B in a Brazilian population.
LID - 10.4238/gmr16029565 [doi]
AB  - Hepatitis B virus (HBV) infection is a serious public health problem worldwide. 
      The progression of the disease depends on several host and viral factors and may 
      result in fulminant hepatitis (very rare), acute hepatitis with spontaneous 
      clearance, and chronic hepatitis B infection. Previous studies demonstrated that 
      variations in the human leukocyte antigen (HLA) class II (HLA-DPB1 and HLA-DQB2 
      genes) are related to the chronic HBV infection. This study aimed to investigate 
      the association of two single nucleotide polymorphism (SNPs), one in the HLA-DPB1 
      (rs9277535) and one in the HLA-DQB2 (rs7453920), with chronic hepatitis B 
      infection in a southern Brazilian sample. This case-control study included 260 
      HBV patients attended in a Specialized Center for Health in Caxias do Sul 
      (Brazil) between 2014 and 2016. The same number of controls (matching for age, 
      gender, and ethnicity) was obtained in a University Hospital in the same city and 
      period. Blood samples were collected and genomic DNA was extracted. Genotyping 
      were performed by real-time Taqman PCR method. Odds ratios with 95% confidence 
      intervals and significance level of 5% (P < 0.05) were calculated. Allele 
      frequencies in the SNP rs9277535 were 72.6% for A and 27.4% for G nucleotides in 
      cases and 75.0% for A and 25.0% for G in controls. Allele frequencies in the SNP 
      rs7453920 were of 25.7% for A and 74.3% for G in cases and 28.8% for A and 71.2% 
      for G in controls. No statistically significant association was found between 
      both SNPs and chronic hepatitis B (P > 0.05).
FAU - Pereira, V R Z B
AU  - Pereira VRZB
AD  - , , Brasil.
AD  - Prefeitura Municipal de Caxias do Sul, Servico Municipal de Infectologia, , 
      Brasil.
AD  - Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude, , , 
      Brasil.
FAU - Wolf, J M
AU  - Wolf JM
AD  - Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude, , , 
      Brasil jonasmwolf@gmail.com.
AD  - Laboratorio de Diagnostico Molecular, , , Brasil jonasmwolf@gmail.com.
FAU - Stumm, G Z
AU  - Stumm GZ
AD  - , , Brasil.
FAU - Boeira, T R
AU  - Boeira TR
AD  - Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude, , , 
      Brasil.
AD  - Laboratorio de Diagnostico Molecular, , , Brasil.
FAU - Galvan, J
AU  - Galvan J
AD  - Prefeitura Municipal de Caxias do Sul, Servico Municipal de Infectologia, , 
      Brasil.
FAU - Simon, D
AU  - Simon D
AD  - Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude, , , 
      Brasil.
FAU - Lunge, V R
AU  - Lunge VR
AD  - Programa de Pos-Graduacao em Biologia Celular e Molecular Aplicada a Saude, , , 
      Brasil.
AD  - Laboratorio de Diagnostico Molecular, , , Brasil.
LA  - eng
PT  - Journal Article
DEP - 20170531
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-Dx antigen)
SB  - IM
MH  - Adult
MH  - Brazil
MH  - Case-Control Studies
MH  - Female
MH  - HLA-DP beta-Chains/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - Hepatitis B, Chronic/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
EDAT- 2017/06/15 06:00
MHDA- 2017/10/07 06:00
CRDT- 2017/06/15 06:00
PHST- 2017/06/15 06:00 [entrez]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2017/10/07 06:00 [medline]
AID - gmr-16-02-gmr.16029565 [pii]
AID - 10.4238/gmr16029565 [doi]
PST - epublish
SO  - Genet Mol Res. 2017 May 31;16(2). doi: 10.4238/gmr16029565.