PMID- 28613411
OWN - NLM
STAT- MEDLINE
DCOM- 20190708
LR  - 20190708
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 12
IP  - 4
DP  - 2018 Aug
TI  - Outcome in patients converting to psychosis following a treated clinical high 
      risk state.
PG  - 715-719
LID - 10.1111/eip.12431 [doi]
AB  - AIM: We explored 2-year outcomes in a sample of clinical high risk (CHR) patients 
      who converted to psychosis despite receiving interventions. METHODS: Of 167 CHR 
      patients, 18 had converted to psychosis and received treatment for their first 
      episode of psychosis in an early intervention service over 2 years. RESULTS: 
      Compared to patients admitted directly to the same early intervention service 
      without having been identified as CHR prior to onset of psychosis, CHR converters 
      were in remission for fewer months (M = 5 vs M = 10); were more likely to be 
      prescribed more than 1 antipsychotic medication (90% vs 68%) and to receive 
      clozapine treatment (38% vs 2%) over 2 years. CONCLUSIONS: CHR patients who 
      convert to psychosis may be inherently more resistant to comprehensive treatment 
      and may have poorer outcomes. Conversion to psychosis from a state of CHR can be 
      reduced to a rate of 10%-12% following interventions, yet outcomes for patients 
      who convert despite such interventions remain unexplored.
CI  - (c) 2017 John Wiley & Sons Australia, Ltd.
FAU - Malla, Ashok
AU  - Malla A
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
AD  - ACCESS Open minds/Esprits ouverts, Douglas Mental Health University Institute, 
      Montreal, Quebec, Canada.
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - de Bonneville, Marianne
AU  - de Bonneville M
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
FAU - Shah, Jai
AU  - Shah J
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
AD  - ACCESS Open minds/Esprits ouverts, Douglas Mental Health University Institute, 
      Montreal, Quebec, Canada.
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - Jordan, Gerald
AU  - Jordan G
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
AD  - ACCESS Open minds/Esprits ouverts, Douglas Mental Health University Institute, 
      Montreal, Quebec, Canada.
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - Pruessner, Marita
AU  - Pruessner M
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - Faridi, Kia
AU  - Faridi K
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
FAU - Rabinovitch, Mark
AU  - Rabinovitch M
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
FAU - Iyer, Srividya N
AU  - Iyer SN
AUID- ORCID: 0000-0001-5367-9086
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
AD  - ACCESS Open minds/Esprits ouverts, Douglas Mental Health University Institute, 
      Montreal, Quebec, Canada.
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
FAU - Joober, Ridha
AU  - Joober R
AD  - Prevention and Early Intervention Program for Psychoses, Douglas Mental Health 
      University Institute, Montreal, Quebec, Canada.
AD  - ACCESS Open minds/Esprits ouverts, Douglas Mental Health University Institute, 
      Montreal, Quebec, Canada.
AD  - Department of Psychiatry, McGill University, Montreal, Quebec, Canada.
LA  - eng
GR  - CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170614
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antipsychotic Agents/therapeutic use
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/drug therapy/*therapy
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - clinical high risk for psychosis
OT  - clozapine
OT  - first-episode psychosis
OT  - outcome
OT  - remission
EDAT- 2017/06/15 06:00
MHDA- 2019/07/10 06:00
CRDT- 2017/06/15 06:00
PHST- 2016/05/04 00:00 [received]
PHST- 2016/11/21 00:00 [revised]
PHST- 2016/12/24 00:00 [accepted]
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2019/07/10 06:00 [medline]
PHST- 2017/06/15 06:00 [entrez]
AID - 10.1111/eip.12431 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2018 Aug;12(4):715-719. doi: 10.1111/eip.12431. Epub 
      2017 Jun 14.