PMID- 28614118
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20221104
IS  - 1473-6543 (Electronic)
IS  - 1062-4821 (Print)
IS  - 1062-4821 (Linking)
VI  - 26
IP  - 5
DP  - 2017 Sep
TI  - The renal response to potassium stress: integrating past with present.
PG  - 411-418
LID - 10.1097/MNH.0000000000000352 [doi]
AB  - PURPOSE OF REVIEW: The current review combines past findings with recent advances 
      in our understanding of the homeostatic response to potassium imbalance. RECENT 
      FINDINGS: Following the ingestion of a dietary potassium load, a combination of 
      extrarenal and renal mechanisms act to maintain extracellular K+ within a tight 
      window. Through hormonal regulation and direct K+ sensing, the nephron is ideally 
      suited to respond to wide shifts in external K+ balance. Current evidence 
      indicates that dietary K+ loading triggers a coordinated kaliuretic response that 
      appears to involve voltage-dependent changes in sodium transport across multiple 
      nephron segments, including the proximal tubule, medullary loop of Henle, and 
      distal tubule. Inhibition of sodium transport in these segments would accomplish 
      the final goal of enhancing distal NaCl delivery, luminal flow, and K+ secretion 
      in the aldosterone sensitive distal nephron (ASDN). SUMMARY: Ongoing research 
      seeks to define the relationship between potassium and volume homeostasis by 
      elucidating pathways that couple renal K+ sensing and tubular function during the 
      potassium stress response.
FAU - Boyd-Shiwarski, Cary R
AU  - Boyd-Shiwarski CR
AD  - aDepartment of Medicine, Renal-Electrolyte Division bDepartment of Cell Biology, 
      University of Pittsburgh School of Medicine cVA Pittsburgh Healthcare System, 
      Pittsburgh, Pennsylvania, USA.
FAU - Subramanya, Arohan R
AU  - Subramanya AR
LA  - eng
GR  - P30 DK079307/DK/NIDDK NIH HHS/United States
GR  - R01 DK098145/DK/NIDDK NIH HHS/United States
GR  - T32 DK061296/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Curr Opin Nephrol Hypertens
JT  - Current opinion in nephrology and hypertension
JID - 9303753
RN  - 0 (Potassium, Dietary)
RN  - 9NEZ333N27 (Sodium)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Homeostasis
MH  - Humans
MH  - Ion Transport
MH  - Nephrons/*metabolism
MH  - Potassium/*metabolism
MH  - Potassium, Dietary/*administration & dosage
MH  - Sodium/metabolism
MH  - Stress, Physiological
PMC - PMC9624486
MID - NIHMS929770
COIS- Conflicts of interest There are no conflicts of interest.
EDAT- 2017/06/15 06:00
MHDA- 2018/04/18 06:00
PMCR- 2022/11/01
CRDT- 2017/06/15 06:00
PHST- 2017/06/15 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/06/15 06:00 [entrez]
PHST- 2022/11/01 00:00 [pmc-release]
AID - 10.1097/MNH.0000000000000352 [doi]
PST - ppublish
SO  - Curr Opin Nephrol Hypertens. 2017 Sep;26(5):411-418. doi: 
      10.1097/MNH.0000000000000352.