PMID- 28615544
OWN - NLM
STAT- MEDLINE
DCOM- 20170831
LR  - 20240326
IS  - 1463-1741 (Print)
IS  - 1998-4030 (Electronic)
IS  - 1463-1741 (Linking)
VI  - 19
IP  - 88
DP  - 2017 May-Jun
TI  - Evidence of associations between brain-derived neurotrophic factor (BDNF) serum 
      levels and gene polymorphisms with tinnitus.
PG  - 140-148
LID - 10.4103/nah.NAH_74_16 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) gene polymorphisms are 
      associated with abnormalities in regulation of BDNF secretion. Studies also 
      linked BDNF polymorphisms with changes in brainstem auditory-evoked response test 
      results. Furthermore, BDNF levels are reduced in tinnitus, psychiatric disorders, 
      depression, dysthymic disorder that may be associated with stress, conversion 
      disorder, and suicide attempts due to crises of life. For this purpose, we 
      investigated whether there is any role of BDNF changes in the pathophysiology of 
      tinnitus. MATERIALS AND METHODS: In this study, we examined the possible effects 
      of BDNF variants in individuals diagnosed with tinnitus for more than 3 months. 
      Fifty-two tinnitus subjects between the ages of 18 and 55, and 42 years healthy 
      control subjects in the same age group, who were free of any otorhinolaryngology 
      and systemic disease, were selected for examination. The intensity of tinnitus 
      and depression was measured using the tinnitus handicap inventory, and the 
      differential diagnosis of psychiatric diagnoses made using the Structured 
      Clinical Interview for Fourth Edition of Mental Disorders. BDNF gene polymorphism 
      was analyzed in the genomic deoxyribonucleic acid (DNA) samples extracted from 
      the venous blood, and the serum levels of BDNF were measured. One-way analysis of 
      variance and Chi-squared tests were applied. RESULTS: Serum BDNF level was found 
      lower in the tinnitus patients than controls, and it appeared that there is no 
      correlation between BDNF gene polymorphism and tinnitus. CONCLUSIONS: This study 
      suggests neurotrophic factors such as BDNF may have a role in tinnitus etiology. 
      Future studies with larger sample size may be required to further confirm our 
      results.
FAU - Coskunoglu, Aysun
AU  - Coskunoglu A
AD  - Department of Medical Genetics, Faculty of Medicine, Celal Bayar University, 
      Manisa, Turkey.
FAU - Orenay-Boyacioglu, Seda
AU  - Orenay-Boyacioglu S
AD  - Department of Medical Genetics, Faculty of Medicine, Adnan Menderes University, 
      Efeler, Aydin, Turkey.
FAU - Deveci, Artuner
AU  - Deveci A
AD  - Department of Psychiatry, Faculty of Medicine, Celal Bayar University, Manisa, 
      Turkey.
FAU - Bayam, Mustafa
AU  - Bayam M
AD  - Department of Otorhinolaryngology, Faculty of Medicine, Celal Bayar University, 
      Manisa, Turkey.
FAU - Onur, Ece
AU  - Onur E
AD  - Department of Medical Biochemistry, Faculty of Medicine, Celal Bayar University, 
      Manisa, Turkey.
FAU - Onan, Arzu
AU  - Onan A
AD  - Department of Medical Biochemistry, Faculty of Medicine, Celal Bayar University, 
      Manisa, Turkey.
FAU - Cam, Fethi S
AU  - Cam FS
AD  - Department of Medical Genetics, Faculty of Medicine, Celal Bayar University, 
      Manisa, Turkey.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Noise Health
JT  - Noise & health
JID - 9815620
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - Case-Control Studies
MH  - Depression/psychology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Tinnitus/blood/*genetics/psychology
MH  - Young Adult
PMC - PMC5501024
COIS- There are no conflicts of interest.
EDAT- 2017/06/16 06:00
MHDA- 2017/09/01 06:00
PMCR- 2017/05/01
CRDT- 2017/06/16 06:00
PHST- 2017/06/16 06:00 [entrez]
PHST- 2017/06/16 06:00 [pubmed]
PHST- 2017/09/01 06:00 [medline]
PHST- 2017/05/01 00:00 [pmc-release]
AID - NoiseHealth_2017_19_88_140_208044 [pii]
AID - NH-19-140 [pii]
AID - 10.4103/nah.NAH_74_16 [doi]
PST - ppublish
SO  - Noise Health. 2017 May-Jun;19(88):140-148. doi: 10.4103/nah.NAH_74_16.