PMID- 28616576
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2372-3556 (Print)
IS  - 2372-3556 (Electronic)
IS  - 2372-3556 (Linking)
VI  - 4
IP  - 3
DP  - 2017
TI  - Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR.
PG  - e1297284
LID - 10.1080/23723556.2017.1297284 [doi]
LID - e1297284
AB  - A master promoter of cell growth, mammalian target of rapamycin (mTOR) is 
      upregulated in a large percentage of cancer cells. Still, targeting mTOR using 
      rapamycin has a limited outcome in patients. Our recent results highlight the 
      additional role of mTOR as a tumor suppressor, explaining these modest results in 
      the clinic.
FAU - Villar, Victor H
AU  - Villar VH
AD  - Institut Europeen de Chimie et Biologie, Pessac, France.
AD  - Institut Bergonie, ACTION Unit U1218 INSERM, Bordeaux, France.
AD  - University of Bordeaux, Bordeaux, France.
FAU - Nguyen, Tra Ly
AU  - Nguyen TL
AD  - Institut Europeen de Chimie et Biologie, Pessac, France.
AD  - Institut Bergonie, ACTION Unit U1218 INSERM, Bordeaux, France.
AD  - University of Bordeaux, Bordeaux, France.
FAU - Teres, Silvia
AU  - Teres S
AD  - Institut Europeen de Chimie et Biologie, Pessac, France.
AD  - Institut Bergonie, ACTION Unit U1218 INSERM, Bordeaux, France.
AD  - University of Bordeaux, Bordeaux, France.
FAU - Bodineau, Clement
AU  - Bodineau C
AD  - Institut Europeen de Chimie et Biologie, Pessac, France.
AD  - Institut Bergonie, ACTION Unit U1218 INSERM, Bordeaux, France.
AD  - University of Bordeaux, Bordeaux, France.
FAU - Duran, Raul V
AU  - Duran RV
AD  - Institut Europeen de Chimie et Biologie, Pessac, France.
AD  - Institut Bergonie, ACTION Unit U1218 INSERM, Bordeaux, France.
AD  - University of Bordeaux, Bordeaux, France.
LA  - eng
PT  - Journal Article
DEP - 20170303
PL  - United States
TA  - Mol Cell Oncol
JT  - Molecular & cellular oncology
JID - 101642411
PMC - PMC5462510
OTO - NOTNLM
OT  - autophagy
OT  - cancer metabolism
OT  - glutamoptosis
OT  - mTORC1
OT  - rapamycin
OT  - alpha-ketoglutarate
EDAT- 2017/06/16 06:00
MHDA- 2017/06/16 06:01
PMCR- 2018/03/03
CRDT- 2017/06/16 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/02/16 00:00 [accepted]
PHST- 2017/06/16 06:00 [entrez]
PHST- 2017/06/16 06:00 [pubmed]
PHST- 2017/06/16 06:01 [medline]
PHST- 2018/03/03 00:00 [pmc-release]
AID - 1297284 [pii]
AID - 10.1080/23723556.2017.1297284 [doi]
PST - epublish
SO  - Mol Cell Oncol. 2017 Mar 3;4(3):e1297284. doi: 10.1080/23723556.2017.1297284. 
      eCollection 2017.