PMID- 28616914
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20201209
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 48
IP  - 3
DP  - 2017 May
TI  - [Expressions and Significance of ALDH1, HIF-1alpha and VEGF in Laryngeal Squamous 
      Cell Carcinoma].
PG  - 399-404
AB  - OBJECTIVES: To investigate the expressions of aldehyde dehydrogenase 1(ALDH1), 
      hypoxia-inducible factor 1alpha(HIF-1alpha), vascular endothelial growth factor (VEGF) in 
      laryngeal squamous cell carcinoma(LSCC) and their relationships with clinical 
      significance. METHODS: In situ hybridization (ISH) method and immuohistochemical 
      staining were used to detect the mRNA and protein expressions of ALDH1, HIF-1alpha 
      and VEGF in 120 LSCC specimens and 60 cases of normal laryngeal tissue. Their 
      relationships with clinical pathological parameters were analyzed. RESULTS: The 
      positive rates of ALDH1, HIF-1alpha and VEGF mRNA in LSCC were 57.5% (69/120) , 73.3% 
      (88/120) , 56.7% (68/120) , while the positive rates of proteins were 55.8% 
      (67/120) , 70.8% (85/120) and 55.0% (66/120) , respectively. which were 
      significantly higher than those in controls (P<0.05) . The expression of ALDH1 
      and VEGF proteins were significantly correlated with TNM stage and lymph node 
      metastasis (P<0.05) . The expression of HIF-1alpha protein was significantly 
      correlated with TNM stage, the degree of differentiation and lymph node 
      metastasis (P<0.05). The positive expression of ALDH1 was positively associated 
      with those of HIF-1alpha and VEGF (P<0.05). The lymph node metastasis rate increased 
      with the positive factors. Kaplan-Meier survival analysis showed that the 
      patients with positive expression of ALDH1, HIF-1alpha and VEGF had lower 5-year 
      overall survival rate than those with negative expression (P<0.05) . CONCLUSIONS: 
      The expressions of ALDH1, HIF-1alpha and VEGF are higher in LSCC, which may be used 
      to determine the malignancy and prognosis of LSCC.
FAU - Zhao, Yan
AU  - Zhao Y
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233003, China.
FAU - Jin, Xin
AU  - Jin X
AD  - Department of Surgical Oncology, the First Affiliated Hospital of Bengbu Medical 
      College, Bengbu 233003, China.
FAU - Li, Nan
AU  - Li N
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233003, China.
FAU - Qin, Yan-Zi
AU  - Qin YZ
AD  - Department of Pathology, the First Affiliated Hospital of Bengbu Medical College, 
      Bengbu 233003, China.
FAU - Qian, Jun
AU  - Qian J
AD  - Department of Surgical Oncology, the First Affiliated Hospital of Bengbu Medical 
      College, Bengbu 233003, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Isoenzymes)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - EC 1.2.1 (Aldehyde Dehydrogenase 1 Family)
RN  - EC 1.2.1.36 (ALDH1A1 protein, human)
RN  - EC 1.2.1.36 (Retinal Dehydrogenase)
SB  - IM
MH  - Aldehyde Dehydrogenase 1 Family
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Isoenzymes/*metabolism
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Retinal Dehydrogenase/*metabolism
MH  - Vascular Endothelial Growth Factor A/*metabolism
OTO - NOTNLM
OT  - Aldehyde dehydrogenase 1
OT  - Hypoxia -inducible factor 1alpha
OT  - Immuohistochemistry
OT  - Laryngeal squamous cell carcinoma
OT  - Vascular endothelial growth factor
EDAT- 2017/06/16 06:00
MHDA- 2019/05/30 06:00
CRDT- 2017/06/16 06:00
PHST- 2017/06/16 06:00 [entrez]
PHST- 2017/06/16 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 May;48(3):399-404.