PMID- 28616922
OWN - NLM
STAT- MEDLINE
DCOM- 20190529
LR  - 20190529
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 48
IP  - 3
DP  - 2017 May
TI  - [Clinical Characteristics of Patients with Type 2 Diabetes Mellitus and 
      Obstructive Sleep Apnea Syndrome].
PG  - 441-445
AB  - OBJECTIVES: To compare the clinical characteristics and prevalence of chronic 
      complications in type 2 diabetes mellitus (T2DM) patients with various degrees of 
      obstructive sleep apnea syndrome (OSAS). METHODS: A total of 170 patients with 
      T2DM and OSAS were enrolled in this study. These participants were divided into 
      three groups with low, medium and high apnea-hypopnea index (AHI), respectively. 
      The demographic characteristics, biochemical indicators and chronic complications 
      of the patients in the three groups were compared. Multivariate Logistic 
      regression analysis was performed to determine the associations between chronic 
      complications and OSAS. RESULTS: The patients with severe OSAS had higher waist 
      circumference (P=0.045), higher BMI (P=0.069), higher prevalence of diabetic 
      peripheral neuropathy (DPN), and higher prevalence of diabetic retinopathy (DR) 
      than the patients with mild-moderate OSAS. Similar levels of macrovascular 
      complications were found in the three groups (P>0.05). The logistic regression 
      analyses showed that DPN (OR=1.024, 95%CI 1.002-1.046) and chronic kidney disease 
      (OR=1.026, 95%CI 1.004-1.049) were independent predictors of AHI, adjusting for 
      the lowest oxygen saturation, gender, age, diabetic duration, family history of 
      diabetes, BMI, and HbA1c. Other microvascular and macrovascular complications 
      were not predictors of AHI. CONCLUSIONS: Patients with T2DM and severe OSAS have 
      a higher risk of DPN and DR. Particular attention should be paid to T2DM patients 
      with severe OSAS to prevent complications.
FAU - Tan, Cui-Xia
AU  - Tan CX
AD  - Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China 
      Hospital, Sichuan University, Chengdu 610041, China.
AD  - Department of Endocrinology, the First People's Hospital of Chengdu, Chengdu 
      610041, China.
FAU - Gao, Yun
AU  - Gao Y
AD  - Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China 
      Hospital, Sichuan University, Chengdu 610041, China.
FAU - Wang, Chun
AU  - Wang C
AD  - Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China 
      Hospital, Sichuan University, Chengdu 610041, China.
FAU - Li, Yan
AU  - Li Y
AD  - Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China 
      Hospital, Sichuan University, Chengdu 610041, China.
FAU - Feng, Xiao-Bing
AU  - Feng XB
AD  - West China School of Medicine, Sichuan University, Chengdu 610041, China.
FAU - Cheng, Yang-Fan
AU  - Cheng YF
AD  - West China School of Medicine, Sichuan University, Chengdu 610041, China.
FAU - Zhang, Yang
AU  - Zhang Y
AD  - West China School of Medicine, Sichuan University, Chengdu 610041, China.
FAU - Ran, Xing-Wu
AU  - Ran XW
AD  - Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China 
      Hospital, Sichuan University, Chengdu 610041, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
SB  - IM
MH  - Diabetes Mellitus, Type 2/complications/*pathology
MH  - Diabetic Neuropathies/complications
MH  - Diabetic Retinopathy/complications
MH  - Humans
MH  - Logistic Models
MH  - Multivariate Analysis
MH  - Prevalence
MH  - Risk Factors
MH  - Sleep Apnea, Obstructive/complications/*pathology
MH  - Waist Circumference
OTO - NOTNLM
OT  - Complications
OT  - Obstructive sleep apnea syndrome
OT  - Type 2 diabetes mellitus
EDAT- 2017/06/16 06:00
MHDA- 2019/05/30 06:00
CRDT- 2017/06/16 06:00
PHST- 2017/06/16 06:00 [entrez]
PHST- 2017/06/16 06:00 [pubmed]
PHST- 2019/05/30 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2017 May;48(3):441-445.