PMID- 28617135
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20190215
IS  - 1552-695X (Electronic)
IS  - 1534-7354 (Print)
IS  - 1534-7354 (Linking)
VI  - 17
IP  - 2
DP  - 2018 Jun
TI  - Influence of Personalized Exercise Recommendations During Rehabilitation on the 
      Sustainability of Objectively Measured Physical Activity Levels, Fatigue, and 
      Fatigue-Related Biomarkers in Patients With Breast Cancer.
PG  - 306-311
LID - 10.1177/1534735417713301 [doi]
AB  - PURPOSE: Only one-third of patients with breast cancer reach the recommended 
      activity level of 15 to 25 MET h/wk. The aim of this study was to determine the 
      influence of personalized exercise recommendations during rehabilitation on 
      patients' physical activity level, fatigue, and self-perceived cognitive function 
      as well as on side effect-associated biomarkers. METHODS: Total metabolic rate, 
      physical activity level, mean MET and steps, fatigue, self-perceived cognitive 
      functioning , and biomarkers (C-reactive protein [CRP], interleukin 6, macrophage 
      migration inhibiting factor [MIF], tumor necrosis factor [TNF]-alpha, brain-derived 
      neurotrophic factor [BDNF], insulin-like growth factor 1 [IGF1]) were assessed in 
      60 patients with breast cancer in the aftercare phase before ( t(0)) and 8 months 
      after ( t(1)) the intervention. The rehabilitation program consisted of an 
      initial 3-week period and a 1-week stay after 4 months. RESULTS: Paired t-test 
      indicated a statistically significant increase in all activity outcomes from t(0) 
      to t(1). Patients' mean activity level significantly increased from 14.89 to 
      17.88 MET h/wk. Fatigue and self-perceived cognitive functioning significantly 
      improved from t(0) to t(1). CRP levels significantly decreased, and BDNF as well 
      as IGF1 levels significantly increased over time. Correlation analysis revealed 
      statistically significant negative associations between fatigue, physical 
      activity, and markers of inflammation (TNF-alpha and MIF). Furthermore, significant 
      positive correlations between subjective cognitive functioning and all dimensions 
      of fatigue were observed. CONCLUSIONS: The results support the importance of 
      personalized exercise recommendations to increase physical activity levels in 
      patients with breast cancer. Furthermore, the results highlighti an association 
      between physical activity, fatigue, and inflammation.
FAU - Zimmer, Philipp
AU  - Zimmer P
AD  - 2 National Center for Tumor Diseases (NCT) and German Cancer Research Center, 
      Heidelberg, Germany.
FAU - Baumann, Freerk T
AU  - Baumann FT
AD  - 3 Department I of Internal Medicine, Center for integrated oncology Cologne Bonn, 
      University Hospital of Cologne, Cologne, Germany.
FAU - Oberste, Max
AU  - Oberste M
AD  - 1 German Sport University Cologne, Cologne, Germany.
FAU - Schmitt, Joachim
AU  - Schmitt J
AD  - 4 Klinik Am Kurpark, Bad Kissingen, Germany.
FAU - Joisten, Niklas
AU  - Joisten N
AD  - 1 German Sport University Cologne, Cologne, Germany.
FAU - Hartig, Philipp
AU  - Hartig P
AD  - 1 German Sport University Cologne, Cologne, Germany.
FAU - Schenk, Alexander
AU  - Schenk A
AD  - 1 German Sport University Cologne, Cologne, Germany.
FAU - Kuhn, Rafaela
AU  - Kuhn R
AD  - 4 Klinik Am Kurpark, Bad Kissingen, Germany.
FAU - Bloch, Wilhelm
AU  - Bloch W
AD  - 1 German Sport University Cologne, Cologne, Germany.
FAU - Reuss-Borst, Monika
AU  - Reuss-Borst M
AD  - 5 Facharztpraxis am Rehabilitations und Praventionszentrum, Bad Bocklet, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170615
PL  - United States
TA  - Integr Cancer Ther
JT  - Integrative cancer therapies
JID - 101128834
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/*blood
MH  - Breast Neoplasms/*blood/*physiopathology
MH  - Exercise/*physiology
MH  - Fatigue/blood/*physiopathology
MH  - Female
MH  - Humans
MH  - Inflammation/blood/physiopathology
MH  - Middle Aged
MH  - Quality of Life
PMC - PMC6041930
OTO - NOTNLM
OT  - cancer
OT  - cognition
OT  - cytokines
OT  - exercise
OT  - fatigue
OT  - inflammation
OT  - personalized exercise recommendations
OT  - physical activity
OT  - rehabilitation
COIS- Declaration of Conflicting Interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2017/06/16 06:00
MHDA- 2019/02/05 06:00
PMCR- 2017/06/15
CRDT- 2017/06/16 06:00
PHST- 2017/06/16 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2017/06/16 06:00 [entrez]
PHST- 2017/06/15 00:00 [pmc-release]
AID - 10.1177_1534735417713301 [pii]
AID - 10.1177/1534735417713301 [doi]
PST - ppublish
SO  - Integr Cancer Ther. 2018 Jun;17(2):306-311. doi: 10.1177/1534735417713301. Epub 
      2017 Jun 15.