PMID- 28617989
OWN - NLM
STAT- MEDLINE
DCOM- 20171017
LR  - 20181113
IS  - 1365-2567 (Electronic)
IS  - 0019-2805 (Print)
IS  - 0019-2805 (Linking)
VI  - 152
IP  - 3
DP  - 2017 Nov
TI  - 1,25-dihydroxyvitamin D(3) -induced dendritic cells suppress experimental 
      autoimmune encephalomyelitis by increasing proportions of the regulatory 
      lymphocytes and reducing T helper type 1 and type 17 cells.
PG  - 414-424
LID - 10.1111/imm.12776 [doi]
AB  - Dendritic cells (DCs), a bridge for innate and adaptive immune responses, play a 
      key role in the development of multiple sclerosis (MS) and experimental 
      autoimmune encephalomyelitis (EAE), an animal model for MS. Administration of 
      tolerogenic DCs has been used as an immunotherapy in autoimmune diseases. 
      Deficiency of vitamin D is an environmental risk factor of MS. In this study, we 
      induced tolerogenic DCs by 1,25-dihydroxyvitamin D(3) and transferred the 
      tolerogenic DCs (VD(3) -DCs) into EAE mice by adoptive transfer. We found that 
      VD(3) -DCs inhibited the infiltrations of T helper type 1 (Th1) and Th17 cells 
      into spinal cord and increased the proportions of regulatory T cells (CD4(+) 
      CD25(+) Foxp3(+) ), CD4(+) IL-10(+) T cells and regulatory B cells (CD19(+) 
      CD5(+) CD1d(+) ) in peripheral immune organs, which resulted in attenuated EAE. 
      However, the proportions of T helper type 1 (Th1) and Th17 cells in spleen and 
      lymph nodes and the levels of pro-inflammatory cytokines and IgG in serum also 
      increased after transfer of VD(3) -DCs. We conclude that transfer of VD(3) -DCs 
      suppressed EAE by increasing proportions of regulatory T cells, CD4(+) IL-10(+) T 
      cells and regulatory B cells in spleen and reducing infiltration of Th1 and Th17 
      cells into spinal cord, which suggests a possible immunotherapy method using 
      VD(3) -DCs in MS.
CI  - (c) 2017 John Wiley & Sons Ltd.
FAU - Xie, Zhongxiang
AU  - Xie Z
AD  - Department of Neurology and Neuroscience Centre, The First Hospital of Jilin 
      University, Changchun, China.
FAU - Chen, Jingtao
AU  - Chen J
AD  - Institute of Translational Medicine, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Zheng, Chao
AU  - Zheng C
AD  - Department of Neurology and Neuroscience Centre, The First Hospital of Jilin 
      University, Changchun, China.
FAU - Wu, Jing
AU  - Wu J
AD  - Institute of Translational Medicine, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Cheng, Yun
AU  - Cheng Y
AD  - Department of Neurology and Neuroscience Centre, The First Hospital of Jilin 
      University, Changchun, China.
FAU - Zhu, Shan
AU  - Zhu S
AD  - Institute of Translational Medicine, The First Hospital of Jilin University, 
      Changchun, China.
FAU - Lin, Chenhong
AU  - Lin C
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 
      Stockholm, Sweden.
FAU - Cao, Qingqing
AU  - Cao Q
AD  - Department of Neurology and Neuroscience Centre, The First Hospital of Jilin 
      University, Changchun, China.
FAU - Zhu, Jie
AU  - Zhu J
AD  - Department of Neurology and Neuroscience Centre, The First Hospital of Jilin 
      University, Changchun, China.
AD  - Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 
      Stockholm, Sweden.
FAU - Jin, Tao
AU  - Jin T
AUID- ORCID: 0000-0002-7028-3419
AD  - Department of Neurology and Neuroscience Centre, The First Hospital of Jilin 
      University, Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170710
PL  - England
TA  - Immunology
JT  - Immunology
JID - 0374672
RN  - 0 (Ergocalciferols)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunologic Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 55248-15-2 (1,25-dihydroxyergocalciferol)
SB  - IM
MH  - *Adoptive Transfer
MH  - Animals
MH  - B-Lymphocytes, Regulatory/immunology/metabolism
MH  - Cells, Cultured
MH  - Chemotaxis, Leukocyte
MH  - Dendritic Cells/*drug effects/immunology/metabolism/*transplantation
MH  - Encephalomyelitis, Autoimmune, Experimental/blood/immunology/*therapy
MH  - Ergocalciferols/*pharmacology
MH  - Female
MH  - Immune Tolerance/*drug effects
MH  - Immunoglobulin G/blood
MH  - Immunologic Factors/*pharmacology
MH  - Interleukin-10/blood/immunology
MH  - Lymph Nodes/immunology/metabolism
MH  - Mice, Inbred C57BL
MH  - Spinal Cord/*immunology/metabolism
MH  - Spleen/immunology/metabolism
MH  - T-Lymphocytes, Regulatory/*immunology/metabolism
MH  - Th1 Cells/*immunology/metabolism
MH  - Th17 Cells/*immunology/metabolism
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/blood/immunology
PMC - PMC5629429
OTO - NOTNLM
OT  - 1,25-dihydroxyvitamin D3
OT  - experimental autoimmune encephalomyelitis
OT  - multiple sclerosis
OT  - tolerogenic dendritic cells
EDAT- 2017/06/16 06:00
MHDA- 2017/10/19 06:00
PMCR- 2018/11/01
CRDT- 2017/06/16 06:00
PHST- 2017/05/04 00:00 [received]
PHST- 2017/06/01 00:00 [revised]
PHST- 2017/06/05 00:00 [accepted]
PHST- 2017/06/16 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/06/16 06:00 [entrez]
PHST- 2018/11/01 00:00 [pmc-release]
AID - IMM12776 [pii]
AID - 10.1111/imm.12776 [doi]
PST - ppublish
SO  - Immunology. 2017 Nov;152(3):414-424. doi: 10.1111/imm.12776. Epub 2017 Jul 10.