PMID- 28619130
OWN - NLM
STAT- MEDLINE
DCOM- 20180110
LR  - 20180110
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 203
DP  - 2017 May
TI  - Occurrence of Mycoplasma hyorhinis infections in fattening pigs and association 
      with clinical signs and pathological lesions of Enzootic Pneumonia.
PG  - 1-5
LID - S0378-1135(16)30380-7 [pii]
LID - 10.1016/j.vetmic.2017.02.001 [doi]
AB  - Respiratory disorders in fattening pigs are of major concern worldwide. 
      Particularly Enzootic Pneumonia remains a problem for the pig industry. This 
      chronic respiratory disease is primarily caused by Mycoplasma hyopneumoniae (M. 
      hyopneumoniae). However, more recently it was hypothesised that M. hyorhinis can 
      also cause similar lung lesions. To investigate the relevance of M. hyorhinis as 
      a cause of pneumonia in fattening pigs 10 farms in Switzerland (considered free 
      of Enzootic Pneumonia) and 20 farms in Germany (regarded as endemic for Enzootic 
      Pneumonia) with a history of chronic and/or recurrent respiratory diseases were 
      included in the study. During a one-time farm visit the coughing index was 
      determined in the batch of oldest fattening pigs in each farm before submission 
      to slaughter. In total, 1375 lungs from these pigs were collected at the abattoir 
      and individually scored for lesions. Furthermore, 600 lungs with, if present, 
      indicative lesions for Enzootic Pneumonia (purple to grey areas of tissue 
      consolidation in the cranio-ventral lung lobes) were tested for mycoplasma 
      species by culture and by real-time PCR for the presence of M. hyorhinis and M. 
      hyopneumoniae. In total, 15.7% of the selected lungs were tested positive for M. 
      hyorhinis by real-time PCR. The prevalence of M. hyorhinis was 10% in Switzerland 
      and 18.5% in Germany and differed significantly between these two countries 
      (p=0.007). M. hyorhinis was detected significantly more often in pneumonic lungs 
      (p=0.004) but no significant association was found between M. hyorhinis and the 
      coughing index or the M. hyopneumoniae status of the pig. M. hyopneumoniae was 
      detected in 0% and 78.5% of the selected lungs in Switzerland and Germany, 
      respectively. We found no evidence that M. hyorhinis alone can lead to similar 
      lung lesions as seen by an infection with M. hyopneumoniae in fattening pigs. In 
      addition, a simultaneous infection with both M. hyorhinis and M. hyopneumoniae 
      did not aggravate the observed lung lesions. Moreover, the presence of M. 
      hyorhinis showed no clinical effect in terms of coughing at least at the end of 
      the fattening phase. However, different levels of virulence of M. hyorhinis 
      isolates as well as interactions with viral pathogens like porcine reproductive 
      and respiratory syndrome virus (PRRSV) or porcine circovirus type 2 (PCV2) were 
      reported in the literature and need to be further investigated.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Luehrs, Adrian
AU  - Luehrs A
AD  - Clinic for Swine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, 
      University of Bern, Bremgartenstr. 109a, 3001 Bern, Switzerland; Field Station 
      for Epidemiology, University of Veterinary Medicine Hannover, Foundation, 
      Bueschelerstr. 9, 49456 Bakum, Germany.
FAU - Siegenthaler, Salome
AU  - Siegenthaler S
AD  - Clinic for Swine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, 
      University of Bern, Bremgartenstr. 109a, 3001 Bern, Switzerland.
FAU - Grutzner, Niels
AU  - Grutzner N
AD  - Clinic for Swine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, 
      University of Bern, Bremgartenstr. 109a, 3001 Bern, Switzerland.
FAU - Grosse Beilage, Elisabeth
AU  - Grosse Beilage E
AD  - Field Station for Epidemiology, University of Veterinary Medicine Hannover, 
      Foundation, Bueschelerstr. 9, 49456 Bakum, Germany.
FAU - Kuhnert, Peter
AU  - Kuhnert P
AD  - Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, 
      Langgassstr. 122, 3001 Bern, Switzerland.
FAU - Nathues, Heiko
AU  - Nathues H
AD  - Clinic for Swine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, 
      University of Bern, Bremgartenstr. 109a, 3001 Bern, Switzerland. Electronic 
      address: heiko.nathues@vetsuisse.unibe.ch.
LA  - eng
PT  - Journal Article
DEP - 20170203
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Cough/veterinary
MH  - Germany/epidemiology
MH  - Mycoplasma Infections/epidemiology/microbiology/*veterinary
MH  - Mycoplasma hyorhinis/*pathogenicity
MH  - Pneumonia of Swine, Mycoplasmal/*epidemiology/microbiology
MH  - Prevalence
MH  - Swine
MH  - Switzerland/epidemiology
OTO - NOTNLM
OT  - Coughing
OT  - Enzootic Pneumonia
OT  - Pig disease
OT  - Prevalence study
EDAT- 2017/06/18 06:00
MHDA- 2018/01/11 06:00
CRDT- 2017/06/17 06:00
PHST- 2016/09/21 00:00 [received]
PHST- 2017/02/01 00:00 [revised]
PHST- 2017/02/01 00:00 [accepted]
PHST- 2017/06/17 06:00 [entrez]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
AID - S0378-1135(16)30380-7 [pii]
AID - 10.1016/j.vetmic.2017.02.001 [doi]
PST - ppublish
SO  - Vet Microbiol. 2017 May;203:1-5. doi: 10.1016/j.vetmic.2017.02.001. Epub 2017 Feb 
      3.