PMID- 28619168
OWN - NLM
STAT- MEDLINE
DCOM- 20180110
LR  - 20180110
IS  - 1873-2542 (Electronic)
IS  - 0378-1135 (Linking)
VI  - 203
DP  - 2017 May
TI  - Comparison of Asian porcine high fever disease isolates of porcine reproductive 
      and respiratory syndrome virus to United States isolates for their ability to 
      cause disease and secondary bacterial infection in swine.
PG  - 6-17
LID - S0378-1135(16)30401-1 [pii]
LID - 10.1016/j.vetmic.2017.02.003 [doi]
AB  - Epidemiologic data from Asian outbreaks of highly-pathogenic (HP) porcine 
      reproductive and respiratory syndrome virus (PRRSV) suggest that disease severity 
      was associated with both the virulence of the PRRSV isolates and secondary 
      bacterial infections. Previous reports have indicated that U.S. isolates of PRRSV 
      predispose to secondary bacterial infections as well, but the severity of disease 
      that occurred in Asia in pigs infected with these HP-PRRSV strains has not been 
      reported in the U.S. The objectives of this research were to compare the 
      pathogenesis of Asian and U.S. PRRSV isolates with regard to their ability to 
      cause disease and predispose to secondary bacterial infections in swine. To 
      address these objectives groups of pigs were infected with 1 of 2 Asian HP-PRRSV 
      strains (rJXwn06 or rSRV07) or 1 of 2 U.S. PRRSV strains (SDSU73 or VR-2332) 
      alone or in combination with Streptococcus suis, Haemophilus parasuis, and 
      Actinobacillus suis. Pigs infected with rJXwn06 exhibited the most severe 
      clinical disease while the pigs infected with rSRV07 and SDSU73 exhibited 
      moderate clinical disease, and pigs infected with VR-2332 exhibited minimal 
      clinical signs. The frequency of secondary bacterial pneumonia was associated 
      with the clinical severity induced by the PRRSV strains evaluated. The levels of 
      proinflammatory cytokines in the serum were often lower for pigs coinfected with 
      virus and bacteria compared to pigs infected with PRRSV alone indicating an 
      alteration in the immune response in coinfected pigs. Combined our results 
      demonstrate that severity of disease appears to be dependent on virulence of the 
      PRRSV strain, and development of secondary bacterial infection.
CI  - Published by Elsevier B.V.
FAU - Brockmeier, Susan L
AU  - Brockmeier SL
AD  - Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA, United States. Electronic address: 
      Susan.Brockmeier@ars.usda.gov.
FAU - Loving, Crystal L
AU  - Loving CL
AD  - Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA, United States.
FAU - Palmer, Mitchel V
AU  - Palmer MV
AD  - Bacterial Diseases Research Unit, National Animal Disease Center, USDA, 
      Agricultural Research Service, Ames, IA, United States.
FAU - Spear, Allyn
AU  - Spear A
AD  - Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA, United States.
FAU - Nicholson, Tracy L
AU  - Nicholson TL
AD  - Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA, United States.
FAU - Faaberg, Kay S
AU  - Faaberg KS
AD  - Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA, United States.
FAU - Lager, Kelly M
AU  - Lager KM
AD  - Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural 
      Research Service, Ames, IA, United States.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170209
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
SB  - IM
MH  - Animals
MH  - Coinfection/veterinary
MH  - Disease Susceptibility/veterinary
MH  - Female
MH  - Haemophilus Infections/microbiology/pathology/*veterinary
MH  - Haemophilus parasuis/pathogenicity
MH  - Lung/microbiology/pathology
MH  - Porcine Reproductive and Respiratory Syndrome/pathology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*pathogenicity
MH  - Streptococcal Infections/microbiology/pathology/*veterinary
MH  - Streptococcus suis/pathogenicity
MH  - Swine
MH  - Swine Diseases/microbiology/pathology/*virology
MH  - Viremia/veterinary
MH  - Virulence
OTO - NOTNLM
OT  - Actinobacillus suis
OT  - Haemophilus parasuis
OT  - Highly pathogenic PRRSV
OT  - PRDC
OT  - PRRSV
OT  - Pathogenesis
OT  - Porcine reproductive and respiratory syndrome virus
OT  - Porcine respiratory disease complex
OT  - Secondary bacterial infection
OT  - Streptococcus suis
OT  - Virulence
EDAT- 2017/06/18 06:00
MHDA- 2018/01/11 06:00
CRDT- 2017/06/17 06:00
PHST- 2016/09/28 00:00 [received]
PHST- 2017/02/07 00:00 [revised]
PHST- 2017/02/08 00:00 [accepted]
PHST- 2017/06/17 06:00 [entrez]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
AID - S0378-1135(16)30401-1 [pii]
AID - 10.1016/j.vetmic.2017.02.003 [doi]
PST - ppublish
SO  - Vet Microbiol. 2017 May;203:6-17. doi: 10.1016/j.vetmic.2017.02.003. Epub 2017 
      Feb 9.