PMID- 28619530
OWN - NLM
STAT- MEDLINE
DCOM- 20180417
LR  - 20180417
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 102
DP  - 2017 Jul 28
TI  - Neural networks underlying language and social cognition during self-other 
      processing in Autism spectrum disorders.
PG  - 116-123
LID - S0028-3932(17)30221-X [pii]
LID - 10.1016/j.neuropsychologia.2017.06.008 [doi]
AB  - The social communication impairments defining autism spectrum disorders (ASD) may 
      be built upon core deficits in perspective-taking, language processing, and 
      self-other representation. Self-referential processing entails the ability to 
      incorporate self-awareness, self-judgment, and self-memory in information 
      processing. Very few studies have examined the neural bases of integrating 
      self-other representation and semantic processing in individuals with ASD. The 
      main objective of this functional MRI study is to examine the role of language 
      and social brain networks in self-other processing in young adults with ASD. 
      Nineteen high-functioning male adults with ASD and 19 age-sex-and-IQ-matched 
      typically developing (TD) control participants made "yes" or "no" judgments of 
      whether an adjective, presented visually, described them (self) or their favorite 
      teacher (other). Both ASD and TD participants showed significantly increased 
      activity in the medial prefrontal cortex (MPFC) during self and other processing 
      relative to letter search. Analyses of group differences revealed significantly 
      reduced activity in left inferior frontal gyrus (LIFG), and left inferior 
      parietal lobule (LIPL) in ASD participants, relative to TD controls. ASD 
      participants also showed significantly weaker functional connectivity of the 
      anterior cingulate cortex (ACC) with several brain areas while processing 
      self-related words. The LIFG and IPL are important regions functionally at the 
      intersection of language and social roles; reduced recruitment of these regions 
      in ASD participants may suggest poor level of semantic and social processing. In 
      addition, poor connectivity of the ACC may suggest the difficulty in meeting the 
      linguistic and social demands of this task in ASD. Overall, this study provides 
      new evidence of the altered recruitment of the neural networks underlying 
      language and social cognition in ASD.
CI  - Published by Elsevier Ltd.
FAU - Kana, Rajesh K
AU  - Kana RK
AD  - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA. Electronic address: rkana@uab.edu.
FAU - Sartin, Emma B
AU  - Sartin EB
AD  - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Stevens, Carl Jr
AU  - Stevens C Jr
AD  - Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Deshpande, Hrishikesh D
AU  - Deshpande HD
AD  - Department of Radiology, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Klein, Christopher
AU  - Klein C
AD  - Department of Psychology, Marietta College, Marietta, OH, USA.
FAU - Klinger, Mark R
AU  - Klinger MR
AD  - Department of Allied Health Sciences, University of North Carolina, Chapel Hill, 
      NC, USA.
FAU - Klinger, Laura Grofer
AU  - Klinger LG
AD  - Department of Psychiatry, TEACCH Autism Program, University of North Carolina, 
      Chapel Hill, NC, USA.
LA  - eng
PT  - Journal Article
DEP - 20170612
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
RN  - S88TT14065 (Oxygen)
SB  - IM
EIN - Neuropsychologia. 2017 Nov;106:418. PMID: 28807328
MH  - Adolescent
MH  - Adult
MH  - *Autism Spectrum Disorder/complications/pathology/psychology
MH  - Brain/diagnostic imaging/physiopathology
MH  - *Brain Mapping
MH  - Cognition Disorders/diagnostic imaging/*etiology
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Language Disorders/*etiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Neural Pathways/diagnostic imaging/physiopathology
MH  - Neuropsychological Tests
MH  - Oxygen/blood
MH  - Photic Stimulation
MH  - *Self Concept
MH  - *Social Behavior
MH  - Young Adult
OTO - NOTNLM
OT  - Autism
OT  - Connectivity
OT  - Language
OT  - Other
OT  - Self
OT  - Social cognition
OT  - fMRI
EDAT- 2017/06/18 06:00
MHDA- 2018/04/18 06:00
CRDT- 2017/06/17 06:00
PHST- 2016/10/03 00:00 [received]
PHST- 2017/04/07 00:00 [revised]
PHST- 2017/06/10 00:00 [accepted]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/04/18 06:00 [medline]
PHST- 2017/06/17 06:00 [entrez]
AID - S0028-3932(17)30221-X [pii]
AID - 10.1016/j.neuropsychologia.2017.06.008 [doi]
PST - ppublish
SO  - Neuropsychologia. 2017 Jul 28;102:116-123. doi: 
      10.1016/j.neuropsychologia.2017.06.008. Epub 2017 Jun 12.