PMID- 28620031
OWN - NLM
STAT- MEDLINE
DCOM- 20170807
LR  - 20171219
IS  - 1470-8752 (Electronic)
IS  - 0300-5127 (Linking)
VI  - 45
IP  - 3
DP  - 2017 Jun 15
TI  - TSPAN7, effector of actin nucleation required for dendritic cell-mediated 
      transfer of HIV-1 to T cells.
PG  - 703-708
LID - 10.1042/BST20160439 [doi]
AB  - Dendritic cells (DCs) have essential roles in early detection of pathogens and 
      activation of both innate and adaptive immune responses. Whereas human DCs are 
      resistant to productive HIV-1 replication, they have a unique ability to take up 
      virus and transmit it efficiently to T lymphocytes. By doing that, HIV-1 may 
      evade, at least in part, the first line of defense of the immune system, 
      exploiting DCs instead to facilitate rapid infection of a large pool of immune 
      cells. While performing an shRNA screen in human primary monocyte-derived DCs, to 
      gain insights into this cell biological process, we discovered the role played by 
      tetraspanin-7 (TSPAN7). This member of the tetraspanin family appears to be a 
      positive regulator of actin nucleation and stabilization, through the ARP2/3 
      complex. By doing so, TSPAN7 limits HIV-1 endocytosis and maintains viral 
      particles on actin-rich dendrites for an efficient transfer toward T lymphocytes. 
      While studying the function of TSPAN7 in the control of actin nucleation, we also 
      discovered the existence in DCs of two opposing forces at the plasma membrane: 
      actin nucleation, a protrusive force which seems to counterbalance actomyosin 
      contraction.
CI  - (c) 2017 The Author(s); published by Portland Press Limited on behalf of the 
      Biochemical Society.
FAU - Menager, Mickael M
AU  - Menager MM
AD  - Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the 
      Skirball Institute, New York University School of Medicine, New York, NY, U.S.A. 
      mickael.menager@institutimagine.org.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Biochem Soc Trans
JT  - Biochemical Society transactions
JID - 7506897
RN  - 0 (Actins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (TSPAN7 protein, human)
RN  - 0 (Tetraspanins)
SB  - IM
MH  - Actins/*metabolism
MH  - Dendritic Cells/immunology/*metabolism/virology
MH  - HIV Infections/immunology
MH  - HIV-1/*immunology
MH  - Humans
MH  - Nerve Tissue Proteins/*immunology
MH  - T-Lymphocytes/*immunology/virology
MH  - Tetraspanins/*immunology
OTO - NOTNLM
OT  - HIV
OT  - actin nucleation
OT  - dendritic cells
OT  - tetraspanins
EDAT- 2017/06/18 06:00
MHDA- 2017/08/08 06:00
CRDT- 2017/06/17 06:00
PHST- 2016/12/08 00:00 [received]
PHST- 2017/03/15 00:00 [revised]
PHST- 2017/03/21 00:00 [accepted]
PHST- 2017/06/17 06:00 [entrez]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2017/08/08 06:00 [medline]
AID - BST20160439 [pii]
AID - 10.1042/BST20160439 [doi]
PST - ppublish
SO  - Biochem Soc Trans. 2017 Jun 15;45(3):703-708. doi: 10.1042/BST20160439.