PMID- 2862017
OWN - NLM
STAT- MEDLINE
DCOM- 19850919
LR  - 20181130
IS  - 0013-7227 (Print)
IS  - 0013-7227 (Linking)
VI  - 117
IP  - 3
DP  - 1985 Sep
TI  - Stimulation by leumorphin of prolactin secretion from the pituitary in rats.
PG  - 1169-74
AB  - The effect of leumorphin (LM), one of big leu-enkephalins derived from 
      preproenkephalin B, on PRL secretion was studied in the rat in vivo and in vitro. 
      Intracerebroventricular injection of synthetic porcine LM (0.06-6 nmol/rat) 
      caused a dose-related increase in plasma PRL levels in urethane-anesthetized male 
      rats and in conscious freely moving rats. Intravenous injection of LM (3 nmol/100 
      g BW) also raised plasma PRL levels in these animals. The plasma PRL response to 
      intracerebroventricular LM (0.6 nmol/rat) was blunted by naloxone (125 
      micrograms/100 g BW, iv). The stimulating effect of LM on PRL release was the 
      most potent among the peptides derived from preproenkephalin B. In in vitro 
      studies, PRL release from superfused anterior pituitary cells was stimulated in a 
      dose-related manner by LM (10(-9)-10(-6) M), and the effect was blunted by 
      naloxone (10(-5) M). These results suggest that LM has a potent stimulating 
      effect on PRL secretion from the pituitary in the rat by acting, at least in 
      part, directly at the pituitary through an opiate receptor.
FAU - Tojo, K
AU  - Tojo K
FAU - Kato, Y
AU  - Kato Y
FAU - Ohta, H
AU  - Ohta H
FAU - Matsushita, N
AU  - Matsushita N
FAU - Shimatsu, A
AU  - Shimatsu A
FAU - Kabayama, Y
AU  - Kabayama Y
FAU - Inoue, T
AU  - Inoue T
FAU - Yanaihara, N
AU  - Yanaihara N
FAU - Imura, H
AU  - Imura H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrinology
JT  - Endocrinology
JID - 0375040
RN  - 0 (Endorphins)
RN  - 0 (Enkephalins)
RN  - 0 (Protein Precursors)
RN  - 36B82AMQ7N (Naloxone)
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 60617-12-1 (beta-Endorphin)
RN  - 69671-17-6 (alpha-neoendorphin)
RN  - 74913-18-1 (Dynorphins)
RN  - 77739-21-0 (beta-neo-endorphin)
RN  - 83335-41-5 (rimorphin)
RN  - 9002-62-4 (Prolactin)
RN  - 93443-35-7 (preproenkephalin)
SB  - IM
MH  - Animals
MH  - Dynorphins/analogs & derivatives/pharmacology
MH  - Endorphins/pharmacology
MH  - Enkephalins/*pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/pharmacology
MH  - Pituitary Gland, Anterior/*drug effects/metabolism
MH  - Prolactin/*metabolism
MH  - Protein Precursors/*pharmacology
MH  - Rats
MH  - Swine
MH  - Thyrotropin-Releasing Hormone/pharmacology
MH  - *beta-Endorphin/*analogs & derivatives
EDAT- 1985/09/01 00:00
MHDA- 1985/09/01 00:01
CRDT- 1985/09/01 00:00
PHST- 1985/09/01 00:00 [pubmed]
PHST- 1985/09/01 00:01 [medline]
PHST- 1985/09/01 00:00 [entrez]
AID - 10.1210/endo-117-3-1169 [doi]
PST - ppublish
SO  - Endocrinology. 1985 Sep;117(3):1169-74. doi: 10.1210/endo-117-3-1169.