PMID- 28620278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 11
DP  - 2017
TI  - Revealing the Dysfunction of Schematic Facial-Expression Processing in 
      Schizophrenia: A Comparative Study of Different References.
PG  - 314
LID - 10.3389/fnins.2017.00314 [doi]
LID - 314
AB  - The use of event-related potential (ERP) recording technology during perceptual 
      and cognitive processing has been studied in order to develop objective 
      diagnostic indexes for people with neuropsychiatric disorders. For example, 
      patients with schizophrenia exhibit consistent abnormalities in face-evoked early 
      components of ERPs and mismatch negativities (MMNs). In most studies, the choice 
      of reference has been the average reference (AVE), but whether this is the most 
      suitable choice is still unknown. The aim of this study was to systematically 
      compare the AVE and reference electrode standardization technique (REST) methods 
      for assessing expressional face-evoked early visual ERPs and visual MMNs (vMMNs) 
      in patients with schizophrenia and healthy controls. The results showed that both 
      the AVE and REST methods could: (1) obtain primary visual-evoked ERPs in the two 
      groups, (2) reveal the neutral and emotional expression discrimination deficit of 
      the P1 component in the patients, which was normal in the healthy controls, (3) 
      reflect reductions of happy vMMNs in the patients compared to the healthy 
      controls, and (4) show right-dominant sad vMMNs only in the patients. On the 
      other hand, compared to the energy distributions of the AVE-obtained potentials, 
      those of REST-obtained early visual ERPs and vMMNs were more concentrated around 
      the temporo-occipital areas. Furthermore, only the REST-obtained vMMNs revealed a 
      significant difference between happy and sad mismatch stimuli in patients with 
      schizophrenia. These results demonstrate that REST technology might provide new 
      insights into neurophysiological factors associated with neuropsychiatric 
      disorders.
FAU - She, Shenglin
AU  - She S
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
FAU - Li, Haijing
AU  - Li H
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
FAU - Ning, Yuping
AU  - Ning Y
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
FAU - Ren, Jianjuan
AU  - Ren J
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
FAU - Wu, Zhangying
AU  - Wu Z
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
FAU - Huang, Rongcheng
AU  - Huang R
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
FAU - Zhao, Jingping
AU  - Zhao J
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
AD  - National Clinical Research Center for Mental Disorders, Mental Health Institute, 
      The Second Xiangya Hospital of Central South UniversityChangsha, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - Beijing Key Laboratory of Epilepsy, Department of Functional Neurosurgery, 
      Epilepsy Center, Sanbo Brain Hospital, Capital Medical UniversityBeijing, China.
FAU - Zheng, Yingjun
AU  - Zheng Y
AD  - Department of General Psychiatry, The Affiliated Brain Hospital of Guangzhou 
      Medical University (Guangzhou Huiai Hospital)Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20170531
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC5450627
OTO - NOTNLM
OT  - average reference (AVE)
OT  - facial expression
OT  - reference electrode standardization technique (REST)
OT  - schizophrenia
OT  - visual mismatch negativity (vMMN)
EDAT- 2017/06/18 06:00
MHDA- 2017/06/18 06:01
PMCR- 2017/01/01
CRDT- 2017/06/17 06:00
PHST- 2017/02/28 00:00 [received]
PHST- 2017/05/18 00:00 [accepted]
PHST- 2017/06/17 06:00 [entrez]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2017/06/18 06:01 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2017.00314 [doi]
PST - epublish
SO  - Front Neurosci. 2017 May 31;11:314. doi: 10.3389/fnins.2017.00314. eCollection 
      2017.