PMID- 28620752 OWN - NLM STAT- MEDLINE DCOM- 20180917 LR - 20181113 IS - 1352-8661 (Electronic) IS - 0968-5243 (Print) IS - 0968-5243 (Linking) VI - 31 IP - 1 DP - 2018 Feb TI - Fatty metaplasia quantification and impact on regional myocardial function as assessed by advanced cardiac MR imaging. PG - 75-85 LID - 10.1007/s10334-017-0639-7 [doi] AB - OBJECTIVE: This study aimed to investigate the advantages of recently developed cardiac imaging techniques of fat-water separation and feature tracking to characterize better individuals with chronic myocardial infarction (MI). MATERIALS AND METHODS: Twenty patients who had a previous MI underwent CMR imaging. The study protocol included routine cine and late gadolinium enhancement (LGE) technique. In addition, mDixon LGE imaging was performed in every patient. Left ventricular (LV) circumferential (Ecc(LV)) and radial (Err(LV)) strain were calculated using dedicated software (CMR(42), Circle, Calgary, Canada). The extent of global scar was measured in LGE and fat-water separated images to compare conventional and recent CMR imaging techniques. RESULTS: The infarct size derived from conventional LGE and fat-water separated images was similar. However, detection of lipomatous metaplasia was only possible with mDixon imaging. Subjects with fat deposition demonstrated a significantly smaller percentage of fibrosis than those without fat (10.68 +/- 5.07% vs. 13.83 +/- 6.30%; p = 0.005). There was no significant difference in Ecc(LV) or Err(LV) between myocardial segments containing fibrosis only and fibrosis with fat. However, Ecc(LV) and Err(LV) values were significantly higher in myocardial segments adjacent to fibrosis with fat deposition than in those adjacent to LGE only. CONCLUSIONS: Advanced CMR imaging ensures more detailed tissue characterization in patients with chronic MI without a relevant increase in imaging and post-processing time. Fatty metaplasia may influence regional myocardial deformation especially in the myocardial segments adjacent to scar tissue. A simplified and shortened myocardial viability CMR protocol might be useful to better characterize and stratify patients with chronic MI. FAU - Lapinskas, Tomas AU - Lapinskas T AUID- ORCID: 0000-0001-7726-6948 AD - Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, 50161, Kaunas, Lithuania. tomas.lapinskas@lsmuni.lt. AD - Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. tomas.lapinskas@lsmuni.lt. AD - DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany. tomas.lapinskas@lsmuni.lt. FAU - Schnackenburg, Bernhard AU - Schnackenburg B AD - Philips Healthcare, Rontgenstrasse 24, 22335, Hamburg, Germany. FAU - Kouwenhoven, Marc AU - Kouwenhoven M AD - Philips Healthcare, Veenpluis 4-6, 5684 PC, Best, The Netherlands. FAU - Gebker, Rolf AU - Gebker R AD - Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. AD - DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany. FAU - Berger, Alexander AU - Berger A AD - Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. FAU - Zaliunas, Remigijus AU - Zaliunas R AD - Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, 50161, Kaunas, Lithuania. FAU - Pieske, Burkert AU - Pieske B AD - Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. AD - DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany. FAU - Kelle, Sebastian AU - Kelle S AD - Department of Internal Medicine/Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. AD - DZHK (German Centre for Cardiovascular Research), Partner Site, Berlin, Germany. LA - eng PT - Journal Article DEP - 20170615 PL - Germany TA - MAGMA JT - Magma (New York, N.Y.) JID - 9310752 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) SB - IM MH - Aged MH - Cardiac Imaging Techniques/*methods/statistics & numerical data MH - Contrast Media MH - Female MH - Gadolinium MH - Heart/*diagnostic imaging MH - Humans MH - Image Interpretation, Computer-Assisted MH - Magnetic Resonance Imaging/*methods/statistics & numerical data MH - Magnetic Resonance Imaging, Cine/methods/statistics & numerical data MH - Male MH - Metaplasia MH - Middle Aged MH - Myocardial Infarction/diagnostic imaging MH - Myocardium/*pathology MH - Retrospective Studies MH - Software PMC - PMC5813049 OTO - NOTNLM OT - Cardiac magnetic resonance OT - Chronic myocardial infarction OT - Fatty metaplasia OT - Fat-water separated imaging OT - Feature tracking COIS- CONFLICT OF INTEREST: The authors declare that they have no competing interests. ETHICAL STANDARDS: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments. FUNDING: This study was not supported with specific funding that could influence study design or results. TL received support from the Lithuanian University of Health Sciences. BS, MK and SK were funded by Philips Healthcare. TL, BP and SK received support from the DZHK (German Centre for Cardiovascular Research). EDAT- 2017/06/18 06:00 MHDA- 2018/09/18 06:00 PMCR- 2017/06/15 CRDT- 2017/06/17 06:00 PHST- 2017/04/04 00:00 [received] PHST- 2017/06/06 00:00 [accepted] PHST- 2017/06/03 00:00 [revised] PHST- 2017/06/18 06:00 [pubmed] PHST- 2018/09/18 06:00 [medline] PHST- 2017/06/17 06:00 [entrez] PHST- 2017/06/15 00:00 [pmc-release] AID - 10.1007/s10334-017-0639-7 [pii] AID - 639 [pii] AID - 10.1007/s10334-017-0639-7 [doi] PST - ppublish SO - MAGMA. 2018 Feb;31(1):75-85. doi: 10.1007/s10334-017-0639-7. Epub 2017 Jun 15.