PMID- 28620818
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20181202
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 437
IP  - 1-2
DP  - 2018 Jan
TI  - Effects of atorvastatin and simvastatin on oxidative stress in diet-induced 
      hyperhomocysteinemia in Wistar albino rats: a comparative study.
PG  - 109-118
LID - 10.1007/s11010-017-3099-5 [doi]
AB  - Considering the well-known antioxidant properties of statins, it seems important 
      to assess their impact on major markers of oxidative stress (superoxide anion 
      radical, nitric oxide, and index of lipid peroxidation) to compare the 
      antioxidative potentials of atorvastatin and simvastatin during the different 
      degrees of hyperhomocysteinemia (HHcy) in rats. This study was conducted on adult 
      male Wistar albino rats (n = 90; 4 weeks old; 100 +/- 15 g body mass) in which HHcy 
      was achieved by dietary manipulation. For 4 weeks, the animals were fed with one 
      of the following diets: standard rodent chow, diet enriched in methionine with no 
      deficiency in B vitamins (folic acid, B6, and B12), or diet enriched in 
      methionine and deficient in B vitamins (folic acid, B6, and B12). At the same 
      time, animals were treated with atorvastatin at doses of 3 mg/kg/day i.p. or 
      simvastatin at doses of 5 mg/kg/day i.p. Levels of superoxide anion radical and 
      TBARS were significantly decreased by administration of simvastatin in normal and 
      high-homocysteine (Hcy) groups (p < 0.05). At 4 weeks after feeding with purified 
      diets, the concentrations of the GSH, CAT, and SOD antioxidants were 
      significantly affected among all groups (p < 0.05). Our results indicated that 
      statin therapy had variable effects on the redox status in hyperhomocysteinemic 
      rats, and simvastatin demonstrated stronger antioxidant effects than did 
      atorvastatin.
FAU - Nikolic, T
AU  - Nikolic T
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Zivkovic, V
AU  - Zivkovic V
AD  - Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica str. 69, P.O. Box 124, 34 000, Kragujevac, Serbia.
FAU - Srejovic, I
AU  - Srejovic I
AD  - Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica str. 69, P.O. Box 124, 34 000, Kragujevac, Serbia.
FAU - Stojic, I
AU  - Stojic I
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Jeremic, N
AU  - Jeremic N
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Jeremic, J
AU  - Jeremic J
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Radonjic, K
AU  - Radonjic K
AD  - Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, 
      Kragujevac, Serbia.
FAU - Stankovic, S
AU  - Stankovic S
AD  - Institute for Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Obrenovic, R
AU  - Obrenovic R
AD  - Institute for Medical Biochemistry, Clinical Centre of Serbia, Belgrade, Serbia.
FAU - Djuric, D
AU  - Djuric D
AD  - Faculty of Medicine, Institute of Medical Physiology "Richard Burian", University 
      of Belgrade, Belgrade, Serbia.
FAU - Jakovljevic, V
AU  - Jakovljevic V
AD  - Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, 
      Svetozara Markovica str. 69, P.O. Box 124, 34 000, Kragujevac, Serbia. 
      drvladakgbg@yahoo.com.
AD  - Department of Human Pathology, University IM Sechenov, 1st Moscow State Medical, 
      Moscow, Russia. drvladakgbg@yahoo.com.
LA  - eng
GR  - 175043/Ministry of Science and Technical Development of the Republic of Serbia/
GR  - 09/2011/Faculty of Medical Sciences, Kragujevac, Serbia/
PT  - Comparative Study
PT  - Journal Article
DEP - 20170615
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 11062-77-4 (Superoxides)
RN  - A0JWA85V8F (Atorvastatin)
RN  - AGG2FN16EV (Simvastatin)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Animals
MH  - Atorvastatin/*pharmacology
MH  - Catalase/blood
MH  - Diet/*adverse effects
MH  - Hyperhomocysteinemia/blood/chemically induced/drug therapy
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Simvastatin/*pharmacology
MH  - Superoxide Dismutase/blood
MH  - Superoxides/blood
MH  - Thiobarbituric Acid Reactive Substances/metabolism
OTO - NOTNLM
OT  - Hyperhomocysteinemia
OT  - Oxidative stress
OT  - Rat
OT  - Statins
EDAT- 2017/06/18 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/06/17 06:00
PHST- 2017/03/29 00:00 [received]
PHST- 2017/06/09 00:00 [accepted]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/06/17 06:00 [entrez]
AID - 10.1007/s11010-017-3099-5 [pii]
AID - 10.1007/s11010-017-3099-5 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2018 Jan;437(1-2):109-118. doi: 10.1007/s11010-017-3099-5. Epub 
      2017 Jun 15.