PMID- 28620993
OWN - NLM
STAT- MEDLINE
DCOM- 20180112
LR  - 20180112
IS  - 1469-1809 (Electronic)
IS  - 0003-4800 (Linking)
VI  - 81
IP  - 4
DP  - 2017 Jul
TI  - The Role of TLR4, TNF-alpha and IL-1beta in Type 2 Diabetes Mellitus Development within 
      a North Indian Population.
PG  - 141-146
LID - 10.1111/ahg.12197 [doi]
AB  - This study investigated the role of IL-1beta-511 (rs16944), TLR4-896 (rs4986790) and 
      TNF-alpha-308 (rs1800629) polymorphisms in type 2 diabetes mellitus (T2DM) among an 
      endogamous Northern Indian population. Four hundred fourteen participants (204 
      T2DM patients and 210 nondiabetic controls) were genotyped for IL-1beta-511, 
      TLR4-896 and TNF-alpha-308 loci. The C allele of IL-1beta-511 was shown to increase T2DM 
      susceptibility by 75% (OR: 1.75 [CI 1.32-2.33]). Having two parents affected by 
      T2DM increased susceptibility by 5.7 times (OR: 5.693 [CI 1.431-22.648]). In this 
      study, we have demonstrated a conclusive association with IL-1beta-511 locus and 
      IL-1beta-511-TLR4-896 diplotype (CC-AA) and T2DM, which warrants further 
      comprehensive analyses in larger cohorts.
CI  - (c) 2017 John Wiley & Sons Ltd/University College London.
FAU - Doody, Natalie E
AU  - Doody NE
AUID- ORCID: 0000-0002-8530-2782
AD  - School of Sport, Exercise and Health Sciences, Loughborough University, 
      Loughborough, UK.
FAU - Dowejko, Monika M
AU  - Dowejko MM
AD  - School of Sport, Exercise and Health Sciences, Loughborough University, 
      Loughborough, UK.
FAU - Akam, Elizabeth C
AU  - Akam EC
AD  - School of Sport, Exercise and Health Sciences, Loughborough University, 
      Loughborough, UK.
FAU - Cox, Nick J
AU  - Cox NJ
AD  - School of Sport, Exercise and Health Sciences, Loughborough University, 
      Loughborough, UK.
FAU - Bhatti, Jasvinder S
AU  - Bhatti JS
AD  - Department of Biotechnology and Bioinformatics, Sri Guru Gobind Singh College, 
      Sector 26, Chandigarh, India.
FAU - Singh, Puneetpal
AU  - Singh P
AD  - Department of Human Genetics, Punjabi University, Patiala, Punjab, India.
FAU - Mastana, Sarabjit S
AU  - Mastana SS
AD  - School of Sport, Exercise and Health Sciences, Loughborough University, 
      Loughborough, UK.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 0 (Interleukin-1beta)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - India
MH  - Interleukin-1beta/*genetics
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic
MH  - Toll-Like Receptor 4/*genetics
MH  - Tumor Necrosis Factor-alpha/*genetics
OTO - NOTNLM
OT  - IL-1beta-511
OT  - Inflammatory gene polymorphisms
OT  - North Indian population
OT  - TLR4 896
OT  - TNF-alpha-308
OT  - Type 2 diabetes mellitus
EDAT- 2017/06/18 06:00
MHDA- 2018/01/13 06:00
CRDT- 2017/06/17 06:00
PHST- 2017/01/23 00:00 [received]
PHST- 2017/04/25 00:00 [accepted]
PHST- 2017/06/17 06:00 [entrez]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/01/13 06:00 [medline]
AID - 10.1111/ahg.12197 [doi]
PST - ppublish
SO  - Ann Hum Genet. 2017 Jul;81(4):141-146. doi: 10.1111/ahg.12197.