PMID- 28621563
OWN - NLM
STAT- MEDLINE
DCOM- 20170918
LR  - 20170918
IS  - 1544-0591 (Electronic)
IS  - 0022-0345 (Linking)
VI  - 96
IP  - 9
DP  - 2017 Aug
TI  - Reduced Mastication Impairs Memory Function.
PG  - 1058-1066
LID - 10.1177/0022034517708771 [doi]
AB  - Mastication is an indispensable oral function related to physical, mental, and 
      social health throughout life. The elderly tend to have a masticatory dysfunction 
      due to tooth loss and fragility in the masticatory muscles with aging, 
      potentially resulting in impaired cognitive function. Masticatory stimulation has 
      influence on the development of the central nervous system (CNS) as well as the 
      growth of maxillofacial tissue in children. Although the relationship between 
      mastication and cognitive function is potentially important in the growth period, 
      the cellular and molecular mechanisms have not been sufficiently elucidated. 
      Here, we show that the reduced mastication resulted in impaired spatial memory 
      and learning function owing to the morphological change and decreased activity in 
      the hippocampus. We used an in vivo model for reduced masticatory stimuli, in 
      which juvenile mice were fed with powder diet and found that masticatory 
      stimulation during the growth period positively regulated long-term spatial 
      memory to promote cognitive function. The functional linkage between mastication 
      and brain was validated by the decrease in neurons, neurogenesis, neuronal 
      activity, and brain-derived neurotrophic factor (BDNF) expression in the 
      hippocampus. These findings taken together provide in vivo evidence for a 
      functional linkage between mastication and cognitive function in the growth 
      period, suggesting a need for novel therapeutic strategies in masticatory 
      function-related cognitive dysfunction.
FAU - Fukushima-Nakayama, Y
AU  - Fukushima-Nakayama Y
AD  - 1 Department of Cell Signaling, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
AD  - 2 Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 
      Bunkyo-ku, Tokyo, Japan.
FAU - Ono, Takehito
AU  - Ono T
AD  - 1 Department of Cell Signaling, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
FAU - Hayashi, M
AU  - Hayashi M
AD  - 1 Department of Cell Signaling, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
FAU - Inoue, M
AU  - Inoue M
AD  - 1 Department of Cell Signaling, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
AD  - 2 Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 
      Bunkyo-ku, Tokyo, Japan.
FAU - Wake, H
AU  - Wake H
AD  - 3 Department of System Physiology, Graduate School of Medicine, Kobe University, 
      Chuo-ku, Kobe, Japan.
FAU - Ono, Takashi
AU  - Ono T
AD  - 2 Department of Orthodontic Science, Oral Health Sciences, Graduate School of 
      Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 
      Bunkyo-ku, Tokyo, Japan.
FAU - Nakashima, T
AU  - Nakashima T
AD  - 1 Department of Cell Signaling, Graduate School of Medical and Dental Sciences, 
      Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.
AD  - 4 Precursory Research for Embryonic Science Technology (PRESTO), Japan Science 
      and Technology Agency (JST), Bunkyo-ku, Tokyo, Japan.
AD  - 5 Japan Agency for Medical Research and Development, Core Research for 
      Evolutional Science and Technology (AMED-CREST), Bunkyo-ku, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170616
PL  - United States
TA  - J Dent Res
JT  - Journal of dental research
JID - 0354343
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cognition/*physiology
MH  - Hippocampus/*physiology
MH  - Immunohistochemistry
MH  - Mastication/*physiology
MH  - Memory Disorders/*physiopathology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neurogenesis/physiology
MH  - Neurons/metabolism
MH  - Random Allocation
MH  - Reverse Transcriptase Polymerase Chain Reaction
OTO - NOTNLM
OT  - growth and development
OT  - memory disorders
OT  - neurogenesis
OT  - neurotrophic factors
OT  - oral health
OT  - synapses
EDAT- 2017/06/18 06:00
MHDA- 2017/09/19 06:00
CRDT- 2017/06/17 06:00
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2017/09/19 06:00 [medline]
PHST- 2017/06/17 06:00 [entrez]
AID - 10.1177/0022034517708771 [doi]
PST - ppublish
SO  - J Dent Res. 2017 Aug;96(9):1058-1066. doi: 10.1177/0022034517708771. Epub 2017 
      Jun 16.