PMID- 28621665
OWN - NLM
STAT- MEDLINE
DCOM- 20180402
LR  - 20181113
IS  - 2050-084X (Electronic)
IS  - 2050-084X (Linking)
VI  - 6
DP  - 2017 Jun 16
TI  - Neural mechanisms of social learning in the female mouse.
LID - e25421 [pii]
LID - 10.7554/eLife.25421 [doi]
AB  - Social interactions are often powerful drivers of learning. In female mice, 
      mating creates a long-lasting sensory memory for the pheromones of the stud male 
      that alters neuroendocrine responses to his chemosignals for many weeks. The 
      cellular and synaptic correlates of pheromonal learning, however, remain unclear. 
      We examined local circuit changes in the accessory olfactory bulb (AOB) using 
      targeted ex vivo recordings of mating-activated neurons tagged with a fluorescent 
      reporter. Imprinting led to striking plasticity in the intrinsic membrane 
      excitability of projection neurons (mitral cells, MCs) that dramatically 
      curtailed their responsiveness, suggesting a novel cellular substrate for 
      pheromonal learning. Plasticity was selectively expressed in the MC ensembles 
      activated by the stud male, consistent with formation of memories for specific 
      individuals. Finally, MC excitability gained atypical activity-dependence whose 
      slow dynamics strongly attenuated firing on timescales of several minutes. This 
      unusual form of AOB plasticity may act to filter sustained or repetitive sensory 
      signals.
FAU - Gao, Yuan
AU  - Gao Y
AD  - Department of Biology, Boston University, Boston, United States.
FAU - Budlong, Carl
AU  - Budlong C
AD  - Department of Biology, Boston University, Boston, United States.
FAU - Durlacher, Emily
AU  - Durlacher E
AD  - Program in Neuroscience and Behavior, Mount Holyoke College, South Hadley, United 
      States.
FAU - Davison, Ian G
AU  - Davison IG
AUID- ORCID: 0000-0003-0998-7676
AD  - Department of Biology, Boston University, Boston, United States.
LA  - eng
GR  - R21 DC013894/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20170616
PL  - England
TA  - Elife
JT  - eLife
JID - 101579614
RN  - 0 (Pheromones)
SB  - IM
CIN - Elife. 2017 Jul 27;6:. PMID: 28749341
MH  - Animals
MH  - Female
MH  - Mice
MH  - Neurons/*drug effects/*physiology
MH  - Olfactory Bulb/*drug effects/*physiology
MH  - Olfactory Perception
MH  - Pheromones/*metabolism
MH  - *Smell
MH  - Social Learning
PMC - PMC5531829
OTO - NOTNLM
OT  - electrophysiology
OT  - learning
OT  - mouse
OT  - neuroscience
OT  - olfactory
OT  - pheromone
OT  - social
COIS- The authors declare that no competing interests exist.
EDAT- 2017/06/18 06:00
MHDA- 2018/04/03 06:00
PMCR- 2017/06/17
CRDT- 2017/06/17 06:00
PHST- 2017/01/26 00:00 [received]
PHST- 2017/06/13 00:00 [accepted]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
PHST- 2017/06/17 06:00 [entrez]
PHST- 2017/06/17 00:00 [pmc-release]
AID - e25421 [pii]
AID - 25421 [pii]
AID - 10.7554/eLife.25421 [doi]
PST - epublish
SO  - Elife. 2017 Jun 16;6:e25421. doi: 10.7554/eLife.25421.