PMID- 28623429
OWN - NLM
STAT- MEDLINE
DCOM- 20180829
LR  - 20231112
IS  - 1573-6830 (Electronic)
IS  - 0272-4340 (Print)
IS  - 0272-4340 (Linking)
VI  - 38
IP  - 3
DP  - 2018 Apr
TI  - BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic 
      Plasticity.
PG  - 579-593
LID - 10.1007/s10571-017-0510-4 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed 
      and extensively studied neurotrophins in the mammalian brain. Among its prominent 
      functions, one can mention control of neuronal and glial development, 
      neuroprotection, and modulation of both short- and long-lasting synaptic 
      interactions, which are critical for cognition and memory. A wide spectrum of 
      processes are controlled by BDNF, and the sometimes contradictory effects of its 
      action can be explained based on its specific pattern of synthesis, comprising 
      several intermediate biologically active isoforms that bind to different types of 
      receptor, triggering several signaling pathways. The functions of BDNF must be 
      discussed in close relation to the stage of brain development, the different 
      cellular components of nervous tissue, as well as the molecular mechanisms of 
      signal transduction activated under physiological and pathological conditions. In 
      this review, we briefly summarize the current state of knowledge regarding the 
      impact of BDNF on regulation of neurophysiological processes. The importance of 
      BDNF for future studies aimed at disclosing mechanisms of activation of signaling 
      pathways, neuro- and gliogenesis, as well as synaptic plasticity is highlighted.
FAU - Kowianski, Przemyslaw
AU  - Kowianski P
AUID- ORCID: 0000-0001-6257-5780
AD  - Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki 
      Street, 80-211, Gdansk, Poland. kowiansk@gumed.edu.pl.
AD  - Department of Health Sciences, Pomeranian University of Slupsk, 64 Bohaterow 
      Westerplatte Str., 76-200, Slupsk, Poland. kowiansk@gumed.edu.pl.
FAU - Lietzau, Grazyna
AU  - Lietzau G
AD  - Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki 
      Street, 80-211, Gdansk, Poland.
FAU - Czuba, Ewelina
AU  - Czuba E
AD  - Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki 
      Street, 80-211, Gdansk, Poland.
FAU - Waskow, Monika
AU  - Waskow M
AD  - Department of Health Sciences, Pomeranian University of Slupsk, 64 Bohaterow 
      Westerplatte Str., 76-200, Slupsk, Poland.
FAU - Steliga, Aleksandra
AU  - Steliga A
AD  - Department of Health Sciences, Pomeranian University of Slupsk, 64 Bohaterow 
      Westerplatte Str., 76-200, Slupsk, Poland.
FAU - Morys, Janusz
AU  - Morys J
AD  - Department of Anatomy and Neurobiology, Medical University of Gdansk, 1 Debinki 
      Street, 80-211, Gdansk, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20170616
PL  - United States
TA  - Cell Mol Neurobiol
JT  - Cellular and molecular neurobiology
JID - 8200709
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism/pharmacology
MH  - Humans
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Receptor, trkB/metabolism
MH  - Signal Transduction/drug effects/*physiology
MH  - Synapses/drug effects/*metabolism
PMC - PMC5835061
OTO - NOTNLM
OT  - BDNF
OT  - Cognition
OT  - Development
OT  - Neurotrophin
OT  - Synaptic plasticity
COIS- The authors declare that they have no competing interests.
EDAT- 2017/06/18 06:00
MHDA- 2018/08/30 06:00
PMCR- 2017/06/16
CRDT- 2017/06/18 06:00
PHST- 2017/04/18 00:00 [received]
PHST- 2017/06/08 00:00 [accepted]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/08/30 06:00 [medline]
PHST- 2017/06/18 06:00 [entrez]
PHST- 2017/06/16 00:00 [pmc-release]
AID - 10.1007/s10571-017-0510-4 [pii]
AID - 510 [pii]
AID - 10.1007/s10571-017-0510-4 [doi]
PST - ppublish
SO  - Cell Mol Neurobiol. 2018 Apr;38(3):579-593. doi: 10.1007/s10571-017-0510-4. Epub 
      2017 Jun 16.