PMID- 28623743
OWN - NLM
STAT- MEDLINE
DCOM- 20180705
LR  - 20180705
IS  - 1879-1484 (Electronic)
IS  - 0021-9150 (Linking)
VI  - 263
DP  - 2017 Aug
TI  - Repeated measurements of serum concentrations of TNF-alpha, interleukin-6 and 
      interleukin-10 in the evaluation of internal carotid artery stenosis progression.
PG  - 97-103
LID - S0021-9150(17)30257-5 [pii]
LID - 10.1016/j.atherosclerosis.2017.06.008 [doi]
AB  - BACKGROUND AND AIMS: The inflammatory process (with TNFalpha, interleukin-6 and 
      interleukin-10 involvement) plays a key role in the development, progression and 
      destabilization of atherosclerotic plaques. The aim of this study was to assess 
      the importance of double-checked measurements of TNFalpha, interleukin-6 (IL-6) and 
      interleukin-10 (Il-10) serum levels in patients with internal carotid artery 
      (ICA) stenosis to determine the dynamics of changes in the stenosis degree and in 
      the ultrasound plaque morphology. METHODS: The study included 65 patients with 
      ICA stenosis. Ultrasound of the carotid arteries was performed during 
      qualification and every 3 months to identify any progression of stenosis degree 
      and dynamics of changes in plaque morphology. Serum concentrations of TNF-alpha, 
      IL-6 and IL-10 were measured during qualification and at month 6 of the study. 
      Calculations considered cytokine concentrations and their indices determined as 
      relative differences of cytokine levels assessed in the first and in second 
      tests. RESULTS: Patients with increasing degree of ICA stenosis had higher 
      indices of IL-6 and IL-10 than patients without any increase in the stenosis 
      degree. In patients with unfavorable dynamics of changes in plaque morphology, 
      significantly higher levels of interleukin-6 were found in the second test; these 
      patients had higher indices of IL-6 and IL-10 than patients with favorable 
      dynamics of atherosclerotic plaque morphology on ultrasound. CONCLUSIONS: 
      Long-term trends in serum concentrations of IL-6 and IL-10 in patients with ICA 
      stenosis allow to predict the progression of the degree of stenosis and the 
      unfavorable change of atherosclerotic plaque morphology.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Puz, Przemyslaw
AU  - Puz P
AD  - Department of Neurology, High School of Science, Medical University of Silesia, 
      Clinical Hospital No 7, Professor Leszek Giec Upper Silesian Medical Centre, 
      Katowice, Poland. Electronic address: ppuz@tlen.pl.
FAU - Lasek-Bal, Anetta
AU  - Lasek-Bal A
AD  - Department of Neurology, High School of Science, Medical University of Silesia, 
      Clinical Hospital No 7, Professor Leszek Giec Upper Silesian Medical Centre, 
      Katowice, Poland.
LA  - eng
PT  - Journal Article
DEP - 20170603
PL  - Ireland
TA  - Atherosclerosis
JT  - Atherosclerosis
JID - 0242543
RN  - 0 (IL10 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Artery, Internal/*metabolism
MH  - Carotid Stenosis/*blood/diagnostic imaging
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Interleukin-10/*blood
MH  - Interleukin-6/*blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Ultrasonography
OTO - NOTNLM
OT  - Carotid stenosis
OT  - Interleukin-10
OT  - Interleukin-6
OT  - Tumor necrosis factor alpha
OT  - Unstable carotid plaque
EDAT- 2017/06/18 06:00
MHDA- 2018/07/06 06:00
CRDT- 2017/06/18 06:00
PHST- 2017/01/20 00:00 [received]
PHST- 2017/05/16 00:00 [revised]
PHST- 2017/06/02 00:00 [accepted]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/07/06 06:00 [medline]
PHST- 2017/06/18 06:00 [entrez]
AID - S0021-9150(17)30257-5 [pii]
AID - 10.1016/j.atherosclerosis.2017.06.008 [doi]
PST - ppublish
SO  - Atherosclerosis. 2017 Aug;263:97-103. doi: 10.1016/j.atherosclerosis.2017.06.008. 
      Epub 2017 Jun 3.