PMID- 28624408 OWN - NLM STAT- MEDLINE DCOM- 20191017 LR - 20191017 IS - 1876-7591 (Electronic) IS - 1876-7591 (Linking) VI - 11 IP - 1 DP - 2018 Jan TI - Native T1 Mapping and Extracellular Volume Mapping for the Assessment of Diffuse Myocardial Fibrosis in Dilated Cardiomyopathy. PG - 48-59 LID - S1936-878X(17)30400-X [pii] LID - 10.1016/j.jcmg.2017.04.006 [doi] AB - OBJECTIVES: The purpose of this study was to examine the histological correlation of native myocardial T1 and extracellular volume fraction (ECV) measurement at 3-T for the assessment of diffuse pathological changes in the myocardial tissue, including myocardial fibrosis and extracellular space in dilated cardiomyopathy (DCM). BACKGROUND: Cardiac magnetic resonance T1 techniques allow the quantification of diffuse myocardial fibrosis. However, there are no definitive head-to-head studies of native T1 versus ECV for the detection, quantification, and characterization of pathological changes in the myocardial tissue in DCM by using histological samples for confirmation. METHODS: A total of 36 subjects with DCM (31 men, mean age 56 +/- 16 years) underwent pre- and post-contrast T1 mapping as well as late gadolinium enhancement (LGE) cardiac magnetic resonance at 3-T. Biopsy samples were used for the quantification of collagen volume fraction using picrosirius red staining and an extracellular space component from hematoxylin and eosin-stained myocardium. RESULTS: Nonischemic LGE was observed in 14 of 36 patients. Although patients with LGE had significantly greater biopsy-proven collagen volume fraction than those without LGE (21 +/- 12% vs. 11 +/- 8%; p < 0.01), there was substantial overlap of collagen volume fraction values between patients with and without LGE. Both native T1 value and ECV were similarly and significantly associated with biopsy-proven collagen volume fraction (r = 0.77 and r = 0.66, respectively; p < 0.05). Furthermore, ECV had a strong correlation with the biopsy-proven extracellular space component (r = 0.86), whereas native T1 had only a moderate correlation (r = 0.55). Interobserver and intraobserver reproducibility for native T1 and ECV were 0.89, 0.95, 0.96, and 0.98, respectively. CONCLUSIONS: Native T1 exhibited comparable ability as ECV measurement in the detection and quantification of histological collagen volume fraction, with high reproducibility, and therefore diffuse myocardial fibrosis in DCM may be reliably assessed by native T1 mapping without the administration of gadolinium contrast agent. In addition, cardiac magnetic resonance-derived ECV showed excellent agreement with histological extracellular space. CI - Copyright (c) 2018 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Nakamori, Shiro AU - Nakamori S AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Dohi, Kaoru AU - Dohi K AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. Electronic address: dohik@clin.medic.mie-u.ac.jp. FAU - Ishida, Masaki AU - Ishida M AD - Department of Radiology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Goto, Yoshitaka AU - Goto Y AD - Department of Radiology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Imanaka-Yoshida, Kyoko AU - Imanaka-Yoshida K AD - Department of Pathology and Matrix Biology, Mie University Graduate School of Medicine, Tsu, Japan; Mie University Research Center for Matrix Biology, Tsu, Japan. FAU - Omori, Taku AU - Omori T AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Goto, Itaru AU - Goto I AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Kumagai, Naoto AU - Kumagai N AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Fujimoto, Naoki AU - Fujimoto N AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Ichikawa, Yasutaka AU - Ichikawa Y AD - Department of Radiology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Kitagawa, Kakuya AU - Kitagawa K AD - Department of Radiology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Yamada, Norikazu AU - Yamada N AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Sakuma, Hajime AU - Sakuma H AD - Department of Radiology, Mie University Graduate School of Medicine, Tsu, Japan. FAU - Ito, Masaaki AU - Ito M AD - Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170614 PL - United States TA - JACC Cardiovasc Imaging JT - JACC. Cardiovascular imaging JID - 101467978 SB - IM CIN - JACC Cardiovasc Imaging. 2018 Jan;11(1):60-63. PMID: 29301712 MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Biopsy MH - Cardiomyopathy, Dilated/*diagnostic imaging/pathology MH - Female MH - Fibrosis MH - Humans MH - *Magnetic Resonance Imaging, Cine MH - Male MH - Middle Aged MH - Myocardium/*pathology MH - Observer Variation MH - Predictive Value of Tests MH - Reproducibility of Results MH - Young Adult OTO - NOTNLM OT - collagen volume fraction OT - diffuse myocardial fibrosis OT - dilated cardiomyopathy OT - extracellular space OT - extracellular volume fraction OT - native T1 mapping EDAT- 2017/06/19 06:00 MHDA- 2019/10/18 06:00 CRDT- 2017/06/19 06:00 PHST- 2016/11/28 00:00 [received] PHST- 2017/03/15 00:00 [revised] PHST- 2017/04/21 00:00 [accepted] PHST- 2017/06/19 06:00 [pubmed] PHST- 2019/10/18 06:00 [medline] PHST- 2017/06/19 06:00 [entrez] AID - S1936-878X(17)30400-X [pii] AID - 10.1016/j.jcmg.2017.04.006 [doi] PST - ppublish SO - JACC Cardiovasc Imaging. 2018 Jan;11(1):48-59. doi: 10.1016/j.jcmg.2017.04.006. Epub 2017 Jun 14.